Takenaka, Junki, Hirata, Kenji, Watanabe, Shiro, Shiraishi, Hideaki, Kohsuke, Kudo. (1401). Neuroblastoma-related severe hypoperfusion in the cerebellum of an infant: A case of opsoclonus-myoclonus syndrome. , 11(1), 93-96. doi: 10.22038/aojnmb.2022.65833.1459
Junki Takenaka; Kenji Hirata; Shiro Watanabe; Hideaki Shiraishi; Kudo Kohsuke. "Neuroblastoma-related severe hypoperfusion in the cerebellum of an infant: A case of opsoclonus-myoclonus syndrome". , 11, 1, 1401, 93-96. doi: 10.22038/aojnmb.2022.65833.1459
Takenaka, Junki, Hirata, Kenji, Watanabe, Shiro, Shiraishi, Hideaki, Kohsuke, Kudo. (1401). 'Neuroblastoma-related severe hypoperfusion in the cerebellum of an infant: A case of opsoclonus-myoclonus syndrome', , 11(1), pp. 93-96. doi: 10.22038/aojnmb.2022.65833.1459
Takenaka, Junki, Hirata, Kenji, Watanabe, Shiro, Shiraishi, Hideaki, Kohsuke, Kudo. Neuroblastoma-related severe hypoperfusion in the cerebellum of an infant: A case of opsoclonus-myoclonus syndrome. , 1401; 11(1): 93-96. doi: 10.22038/aojnmb.2022.65833.1459
Neuroblastoma-related severe hypoperfusion in the cerebellum of an infant: A case of opsoclonus-myoclonus syndrome
Asia Oceania Journal of Nuclear Medicine and Biology
1Department of Diagnostic Imaging, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
2Department of Nuclear Medicine, Hokkaido University Hospital, Sapporo, Japan
3Global Center for Biomedical Science and Engineering, Faculty of Medicine, Hokkaido University, Sapporo, Japan
4Department of Pediatrics, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
5Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan
چکیده
A 2-year-old girl started to wobble without any specific triggers, so the patient was admitted to our hospital's pediatric department. The entire cerebellum showed severe atrophy on MRI and much lower uptake than that in the cerebral cortex on perfusion SPECT. The diagnosis of opsoclonus-myoclonus syndrome (OMS) was suspected. MRI visualized a small mass behind the inferior vena cava. Although its uptake on I-123 MIBG scintigraphy was inconclusive, the mass was surgically removed, and the diagnosis of neuroblastoma was pathologically confirmed. OMS is one of the paraneoplastic neurological syndromes with cerebellar ataxia, myoclonus of the trunk and extremities, and opsoclonus as its main symptoms. Approximately 50% of children cases with OMS are associated with neuroblastoma. The prognosis for neuroblastoma itself with OMS is relatively good, but the neurological prognosis is very poor. If there is decreased blood flow in the cerebellum of an infant, it may be necessary to search for neuroblastoma.
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