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Bagheri, Mona, Nasiri Boroujeni, Shakiba, Ahmadvand, Hassan, Nazari, Afshin, Chehelcheraghi, farzaneh. (1401). Cross talk of vasopressin conditioned cell therapy in ischemic heart disease: Role of oxidative stress markers. , 25(9), 1084-1090. doi: 10.22038/ijbms.2022.62540.13837
Mona Bagheri; Shakiba Nasiri Boroujeni; Hassan Ahmadvand; Afshin Nazari; farzaneh Chehelcheraghi. "Cross talk of vasopressin conditioned cell therapy in ischemic heart disease: Role of oxidative stress markers". , 25, 9, 1401, 1084-1090. doi: 10.22038/ijbms.2022.62540.13837
Bagheri, Mona, Nasiri Boroujeni, Shakiba, Ahmadvand, Hassan, Nazari, Afshin, Chehelcheraghi, farzaneh. (1401). 'Cross talk of vasopressin conditioned cell therapy in ischemic heart disease: Role of oxidative stress markers', , 25(9), pp. 1084-1090. doi: 10.22038/ijbms.2022.62540.13837
Bagheri, Mona, Nasiri Boroujeni, Shakiba, Ahmadvand, Hassan, Nazari, Afshin, Chehelcheraghi, farzaneh. Cross talk of vasopressin conditioned cell therapy in ischemic heart disease: Role of oxidative stress markers. , 1401; 25(9): 1084-1090. doi: 10.22038/ijbms.2022.62540.13837

Cross talk of vasopressin conditioned cell therapy in ischemic heart disease: Role of oxidative stress markers

Iranian Journal of Basic Medical Sciences
مقاله 6، دوره 25، شماره 9، آذر 2022، صفحه 1084-1090    اصل مقاله (690.94 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2022.62540.13837
نویسندگان
Mona Bagheri1؛ Shakiba Nasiri Boroujeni1؛ Hassan Ahmadvand2؛ Afshin Nazari* 3، 4؛ farzaneh Chehelcheraghi* 5
1Student Research Committee, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
2Medicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
3Razi Herbal Medicines Research Center, Department of Physiology, Lorestan University of Medical Science, Khorramabad, Iran
4Cardiovascular Research Center, Shahid Rahimi Hospital, Lorestan University of Medical Sciences, Khorramabad, Iran
5Department of Anatomical Sciences, School of Medicine Lorestan University of Medical Sciences, Khorramabad, Iran
چکیده
Objective(s): Background: Impaired coronary blood flow causes cardiac ischemia. Cellular therapy is a new approach to the treatment of myocardial ischemia. This study aimed to investigate the effect of adipose tissue-derived mesenchymal stem cells (AD-MSCs) conditioned with vasopressin on oxidative stress, perivascular collagen, and angiogenesis caused by myocardial infarction (MI) in rats. 
Materials and Methods: We divided 40 male albino Wistar rats into 4 groups; Control group; No intervention; in experimental groups, after it generated induced MI on models, it divided into three groups: Vehicle group (150 μl of cell-free culture medium received); ASC-MI group (6× 106 AD-MSC received) and AVP-ASC-MI group (received 6 × 106 AD-MSC conditioned with 10 nM vasopressin). Then, histologic parameters and anti-oxidant enzymes were evaluated 7 days post-MI cell injection. 
Results: Arterial muscle diameter improved and collagen deposition around the coronary arteries decreased in cell-received groups compared with the vehicle group. Malondialdehyde (MDA), catalase (CAT), (GSH) Glutathione, and Total Anti-oxidant Capacity (TAC) parameters were not significantly different between the cells received groups compared with the vehicle group. But the Catalase (CAT) parameter in the ASC-MI group had a significant increase from the control group. 
Conclusion: We prepared direct evidence that intramyocardial injection of AD-MSCs reveals the positive cardiac remodeling post-MI in rats, and these useful effects can be more enhanced by administrating injection of conditioned ADSCs with vasopressin.
کلیدواژه‌ها
Anti-oxidants؛ Catalase؛ Coronary vessels؛ Glutathione؛ Malondialdehyde؛ Mesenchymal stem cells؛ Myocardial Infarction؛ Myocardial schemia Oxidative stress؛ Vasopressins
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