The effects of Artemisia absinthium L. on scopolamine-induced learning and memory impairment and brain tissue oxidative damage in adult rats | ||
| Avicenna Journal of Phytomedicine | ||
| دوره 13، شماره 1، فروردین و اردیبهشت 2023، صفحه 70-84 اصل مقاله (977.94 K) | ||
| نوع مقاله: Original Research Article | ||
| شناسه دیجیتال (DOI): 10.22038/ajp.2022.62851.2991 | ||
| نویسندگان | ||
| Marzieh Rahimi1؛ Narges Marefati* 2؛ Farimah Beheshti3؛ Somaieh Ahmadabady4؛ Hassan Rakhshandeh5؛ Mahmoud Hosseini6 | ||
| 1Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 2Department of Physiology and Medical Physics, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran | ||
| 3Neuroscience Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran | ||
| 4Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 5Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 6Psychiatry and Behavioral Sciences Research Center, Mashhad Universityof Medical Sciences, Mashhad, Iran | ||
| چکیده | ||
| Objective: The present study examined the effects of Artemisia absinthium L. on scopolamine-induced memory dysfunction and brain tissue oxidative damage in rats. Materials and Methods: Fifty rats were used in five groups: Control: received dimethyl sulfoxide (DMSO)/saline, Scopolamine: scopolamine (2 mg/kg) was administered along with DMSO/saline, and Scopolamine-Ext 50, Scopolamine-Ext 100, and Scopolamine-Ext 200 groups: A. absinthium hydroalcoholic extract 50, 100 and 200 mg/kg were administered before scopolamine. The Morris water maze (MWM) and passive avoidance (PA) tasks were used for assessment of behavioral parameters. Malondialdehyde (MDA), nitric oxide (NO) metabolites, total thiol, catalase (CAT), and superoxide dismutase (SOD) were measured in the cortex and hippocampus. Results: A. absinthium decreased the delay time and distance traveled to reach the platform in the MWM test (p<0.05-p<0.001). Besides, the extract increased the delay time to pass in the dark and the light time while decreasing the number of entrances and the dark time in the PA task (p<0.05-p<0.001). In biochemical assessments, A. absinthium attenuated NO metabolites (p<0.001) and MDA (p<0.05- p<0.001) while enhanced total thiol (p<0.001), CAT and SOD (both p<0.05-p<0.001). Conclusion: This study revealed that A. absinthium improved memory and learning impairment and brain tissue oxidative damage in scopolamine-treated rats. | ||
| کلیدواژهها | ||
| Artemisia absinthium؛ Memory؛ Oxidative Stress؛ Scopolamine | ||
| مراجع | ||
|
Abareshi A, Anaeigoudari A, Norouzi F, Marefati N, Beheshti F, Saeedjalali M, Hosseini M. 2019. The effects of captopril on lipopolysaccharide-induced sickness behaviors in rats. Vet Res Forum, 10: 199- 205. Akbari HR, Beheshti F, Sadeghnia H, Bafadam S, Baghcheghi Y, Hosseini M. 2019. The effects of captopril on learning and memory impairment induced by scopolamine in rats: anti-oxidative effects. Physiol Pharmacol, 23: 91-100. Amat N, Upur H, Blažeković B. 2010. In vivo hepatoprotective activity of the aqueous extract of Artemisia absinthium L. against chemically and immunologically induced liver injuries in mice. J Ethnopharmacol, 131: 478-484. Amel B, Omar K, Faiza F, Miloud S, Abdelkader A. 2016. Behvior and glutamate transaminase changes in rat exposed to lead and treated by wordwood extract. Int J Pharm Pharm, 8: 208-213. Anaeigoudari A, Soukhtanloo M, Reisi P, Beheshti F, Hosseini M. 2016. Inducible nitric oxide inhibitor aminoguanidine, ameliorates deleterious effects of lipopolysaccharide on memory and long term potentiation in rat. Life Sci, 158: 22-30. Babaei R, Javadi-Paydar M, Sharifian M, Mahdavian S, Almasi-Nasrabadi M, Norouzi A, Dehpour AR. 2012. Involvement of nitric oxide in pioglitazone memory improvement in morphine-induced memory impaired mice. Pharmacol Rahimi et al. AJP, Vol. 13, No. 1, Jan-Feb 2023 82 Biochem Behav, 103: 313-321. Bargi R, Asgharzadeh F, Beheshti F, Hosseini M, Sadeghnia HR, Khazaei M. 2017. The effects of thymoquinone on hippocampal cytokine level, brain oxidative stress status and memory deficits induced by lipopolysaccharide in rats. Cytokine, 96: 173-184. Bastianetto S, Ramassamy C, Poirier J, Quirion R. 1999. Dehydroepiandrosterone (DHEA) protects hippocampal cells from oxidative stress-induced damage. Mol Brain Res, 66, 35-41. Batiha GE-S, Olatunde A, El-Mleeh A, Hetta HF, Al-Rejaie S, Alghamdi S, Zahoor M, Beshbishy AM, Murata T, Zaragoza-Bastida A, Rivero-Perez N. 2020. Bioactive compounds, pharmacological actions, and pharmacokinetics of wormwood (Artemisia absinthium). Antibiotics (Basel), 9: 353. Beheshti F, Akbari HR, Baghcheghi Y, Mansouritorghabeh F, Mortazavi Sani SS, Hosseini M. 2021. Beneficial effects of angiotensin converting enzyme inhibition on scopolamine-induced learning and memory impairment in rats, the roles of brain-derived neurotrophic factor, nitric oxide and neuroinflammation. Clin Exp Hypertens, 43: 505-515. Bora KS, Sharma A. 2010. Neuroprotective effect of Artemisia absinthium L. on focal ischemia and reperfusion-induced cerebral injury. J Ethnopharmacol, 129: 403-409. Bora KS, Sharma A. 2010. Phytochemical and pharmacological potential of Artemisia absinthium Linn. and Artemisia asiatica Nakai: a review. J Pharm Res, 3: 325-328. Bora KS, Sharma A. 2011. Evaluation of antioxidant and free-radical scavenging potential of Artemisia absinthium. Pharm Biol, 49: 1216-1223. Budzynska B, Boguszewska-Czubara A, KrukSlomka M, Skalicka-Wozniak K, Michalak A, Musik I, Biala G. 2015. Effects of imperatorin on scopolamine-induced cognitive impairment and oxidative stress in mice. Psychopharmacology, 232: 931-942. Deepa P, Bae HJ, Park H-B, Kim S-Y, Choi JW, Kim DH, Liu XQ, Ryu JH, Park SJ. 2020. Dracocephalum moldavica attenuates scopolamine-induced cognitive impairment through activation of hippocampal ERKCREB signaling in mice. J Ethnopharmacol, 253: 112651. Dvorkin-Camiel L, Whelan JS. 2008. Tropical american plants in the treatment of infectious diseases. J Diet Suppl, 5: 349- 372. Fukui K, Onodera K, Shinkai T, Suzuki S, Urano S. 2001. Impairment of learning and memory in rats caused by oxidative stress and aging, and changes in antioxidative defense systems. Ann N Y Acad Sci, 928: 168-175. Ghasemi S, Moradzadeh M, Hosseini M, Beheshti F, Sadeghnia HR. 2019. Beneficial effects of Urtica dioica on scopolamineinduced memory impairment in rats: protection against acetylcholinesterase activity and neuronal oxidative damage. Drug Chem Toxicol, 42: 167-175. Hadi A, Hossein N, Shirin P, Najmeh N, Abolfazl M. 2014. Anti-inflammatory and analgesic activities of Artemisia absinthium and chemical composition of its essential oil. Int J Pharm Sci Rev Res, 38: 237-244. Hafez HS, Ghareeb DA, Saleh SR, Abady MM, El Demellawy MA, Hussien H, AbdelMonem N. 2017. Neuroprotective effect of ipriflavone against scopolamine-induced memory impairment in rats. Psychopharmacology, 234: 3037-3053. Hakimi Z, Salmani H, Marefati N, Arab Z, Gholamnezhad Z, Beheshti F, Shafei MN, Hosseini M. 2019. Protective effects of carvacrol on brain tissue inflammation and oxidative stress as well as learning and memory in lipopolysaccharide-challenged rats. Neurotox Res, 37: 965-976. Hallal N, Kharoubi O, Benyettou I, Tair K, Ozaslan M, Aoues A. 2016. In vivo amelioration of oxidative stress by Artemisia absinthium L. administration on mercuric chloride toxicity in brain regions. J Biol Sci, 16: 167-177. Hatziieremia S, Gray A, Ferro V, Paul A, Plevin R. 2006. The effects of cardamonin on lipopolysaccharide‐induced inflammatory protein production and MAP kinase and NFκB signalling pathways in monocytes/macrophages. Br J Pharmacol, 149: 188-198. Hosseini M, Anaeigoudari A, Beheshti F, Soukhtanloo M, Nosratabadi R. 2018. Protective effect against brain tissues oxidative damage as a possible mechanism for beneficial effects of L-arginine on lipopolysaccharide induced memory impairment in rats. Drug Chem Toxicol, 41: 175-181. Neuroprotective effects of Artemisia absinthium L. AJP, Vol. 13, No. 1, Jan-Feb 2023 83 Hosseini M, Mohammadpour T, Karami R, Rajaei Z, Reza Sadeghnia H, Soukhtanloo M. 2015. Effects of the hydro-alcoholic extract of Nigella sativa on scopolamineinduced spatial memory impairment in rats and its possible mechanism. Chin J Integr Med, 21: 438-444. Ishola IO, Adamson FM, Adeyemi OO. 2017. Ameliorative effect of kolaviron, a biflavonoid complex from Garcinia kola seeds against scopolamine-induced memory impairment in rats: role of antioxidant defense system. Metab Brain Dis, 32: 235- 245. Jafarian S, Ling KH, Hassan Z, Perimal‐Lewis L, Sulaiman MR, Perimal EK. 2019. Effect of zerumbone on scopolamine‐induced memory impairment and anxiety‐like behaviours in rats. ADTRCI, 5: 637-643. Kamat PK, Kalani A, Rai S, Swarnkar S, Tota S, Nath C, Tyagi N. 2016. Mechanism of oxidative stress and synapse dysfunction in the pathogenesis of Alzheimer’s disease: understanding the therapeutics strategies. Mol Neurobiol, 53: 648-661. Karimi S, Hejazian SH, Alikhani V, Hosseini M. 2015. The effects of tamoxifen on spatial and nonspatial learning and memory impairments induced by scopolamine and the brain tissues oxidative damage in ovariectomized rats. Adv Biomed Res, 4: 196. Karimi S, Hosseini M, Mahdian Z, Babazadeh B. 2017. Protection against brain tissues oxidative damage as a possible mechanism for improving effects of soy on Scopolamine-induced learning and memory impairments in ovariectomized rats. Ann Med Health Sci Res, 7: 166-172. Kharoubi O, Benyamina A, Hallal N, Benyattou I, Aoues A, Slimani M. 2016. Aluminum induced the oxidative stress modification and behavioral variation in rat. Int J Prev Med, 2: 1-7. Kim M-S, Lee DY, Lee J, Kim HW, Sung SH, Han J-S, Jeon WK. 2018. Terminalia chebula extract prevents scopolamineinduced amnesia via cholinergic modulation and anti-oxidative effects in mice. BMC Complement Altern Med, 18: 136. Lee HG, Kim H, Oh WK, Yu KA, Choe YK, Ahn JS, Kim DS, Kim HS, Dinarello CA, Kim K, Yoon DY. 2004. Tetramethoxy hydroxyflavone p7F downregulates inflammatory mediators via the inhibition of nuclear factor κB. Ann N Y Acad Sci, 1030: 555-568. Liu X, Kim DH, Kim JM, Park SJ, Cai M, Jang DS, Ryu JH. 2012. The memoryameliorating effects of Artemisia princeps var. orientalis against cholinergic dysfunction in mice. Am J Chin Med, 40: 993-1005. Mahmoudi M, Ebrahimzadeh M, Ansaroudi F, Nabavi S, Nabavi S. 2009. Antidepressant and antioxidant activities of Artemisia absinthium L. at flowering stage. Afr J Biotechnol, 8: 7170-7175. Marefati N, Mokhtari-Zaer A, Beheshti F, Karimi S, Mahdian Z, Khodamoradi M, Hosseini M. 2019. The effects of soy on scopolamine-induced spatial learning and memory impairments are comparable to the effects of estradiol. Horm Mol Biol Clin Investig, 39. Mohammadian A, Moradkhani S, Ataei S, Shayesteh TH, Sedaghat M, Kheiripour N, Ranjbar A. 2016. Antioxidative and hepatoprotective effects of hydroalcoholic extract of Artemisia absinthium L. in rat. J HerbMed Pharmacol, 5: 29-32. Mostafa NM. 2018. β-Amyrin rich Bombax ceiba leaf extract with potential neuroprotective activity against scopolamine-induced memory impairment in rats. Rec Nat Prod, 12: 480-492. Msaada K, Salem N, Bachrouch O, Bousselmi S, Tammar S, Alfaify A, Al Sane K, Ben Ammar W, Azeiz S, Haj Brahim A, Hammami M, Selmi S. 2015. Chemical composition and antioxidant and antimicrobial activities of wormwood (Artemisia absinthium L.) essential oils and phenolics. J Chem, 2015: 804658. Ngoupaye GT, Pahaye DB, Ngondi J, Moto FCO, Bum EN. 2017. Gladiolus dalenii lyophilisate reverses scopolamine-induced amnesia and reduces oxidative stress in rat brain. Biomed Pharmacother, 91: 350-357. Parihar M, Chaudhary M, Shetty R, Hemnani T. 2004. Susceptibility of hippocampus and cerebral cortex to oxidative damage in streptozotocin treated mice: prevention by extracts of Withania somnifera and Aloe vera. J Clin Neurosci, 11: 397-402. Postu PA, Sadiki FZ, El Idrissi M, Cioanca O, Trifan A, Hancianu M, Hritcu L. 2019. Pinus halepensis essential oil attenuates the toxic Alzheimer’s amyloid beta (1-42)- induced memory impairment and oxidative Rahimi et al. AJP, Vol. 13, No. 1, Jan-Feb 2023 84 stress in the rat hippocampus. Biomed Pharmacother, 112: 108673. Rabiei Z, Setorki M. 2018. Effect of hydroalcoholic Echium amoenum extract on scopolamine-induced learning and memory impairment in rats. Pharm Biol, 56: 672- 677. Rabiei Z, Setorki M. 2020. Effects of ethanolic extract of Artemisia persica on scopolamine-induced cognitive impairment and anxiety in rats. J Medicinal Plants, 1: 133-142. Rahnama S, Rabiei Z, Alibabaei Z, Mokhtari S, Rafieian-Kopaei M, Deris F. 2015. Antiamnesic activity of Citrus aurantium flowers extract against scopolamine-induced memory impairments in rats. Neurol Sci, 36: 553-560. Rakhshandeh H, Heidari A, Pourbagher-Shahri AM, Rashidi R, Forouzanfar F. 2021. Hypnotic effect of A. absinthium hydroalcoholic extract in pentobarbitaltreated mice. Neurol Res Int, 2021: 5521019. Rashidi R, Ghorbani A, Rakhshandeh H, Mousavi SH. 2020. Protective effect of Artemisia absinthium on 6- hydroxydopamine-induced toxicity in SHSY5Y cell line. Avicenna J Phytomed, 11: 238-246. Rivas-Arancibia S, Guevara-Guzmán R, López-Vidal Y, Rodríguez-Martínez E, Zanardo-Gomes M, Angoa-Pérez M, Raisman-Vozari R. 2010. Oxidative stress caused by ozone exposure induces loss of brain repair in the hippocampus of adult rats. Toxicol Sci, 113: 187-197. Sodhi RK, Jaggi AS, Singh N. 2014. Animal models of dementia and cognitive dysfunction. Life Sci, 109: 73-86. Upadhyay P, Sadhu A, Singh PK, Agrawal A, Ilango K, Purohit S, Dubey GP. 2018. Revalidation of the neuroprotective effects of a United States patented polyherbal formulation on scopolamine induced learning and memory impairment in rats. Biomed Pharmacother, 97: 1046-1052. Zaki HF, Abd-El-Fattah MA, Attia AS. 2014. Naringenin protects against scopolamineinduced dementia in rats. Bull Fac Pharm, 52: 15-25. Zhang T, Kim MJ, Kim MJ, Wu X, Yang HJ, Yuan H, Huang S, Yoon SM, Kim KN, Park S. 2022. Long-term effect of porcine brain enzyme hydrolysate intake on Scopolamineinduced memory impairment in rats. Int J Mol Sci, 23: 3361. | ||
|
آمار تعداد مشاهده مقاله: 14,451 تعداد دریافت فایل اصل مقاله: 10,432 |
||
