Effects of wasp venom on venous thrombosis in rats | ||
| Iranian Journal of Basic Medical Sciences | ||
| مقاله 5، دوره 25، شماره 7، مهر 2022، صفحه 822-826 اصل مقاله (869.48 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22038/ijbms.2022.63219.13962 | ||
| نویسندگان | ||
| Fan-mao Jin1؛ Mei Wang2، 3؛ Xiumei Wu2، 3؛ Huai Xiao2؛ Dexiao Wang2، 4؛ Guang-ming Wang4؛ Cheng-gui Zhang2، 3؛ Hai-rong Zhao* 2، 4، 5 | ||
| 1Lishui City People’s Hospital, Lishui, Zhejiang 323000, People’s Republic of China | ||
| 2Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D, Dali University, Dali, China | ||
| 3National-Local Joint Engineering Research Center of Entomoceutics, Dali University, Dali, China | ||
| 4Genetic Testing Center, The First Affiliated Hospital of Dali University, Dali University, Dali, China | ||
| 53 National-Local Joint Engineering Research Center of Entomoceutics, Dali University, Dali, China | ||
| چکیده | ||
| Objective(s): This study aimed to investigate the potential effects of wasp venom (WV) from Vespa magnifica on antithrombosis in rats with inferior vena cava (IVC) thrombosis. Materials and Methods: The thrombosis rat model was established by improving the IVC stenosis, in which rats were subjected to IVC ligation for 75 min. Rats were administered argatroban (IP) or WV (s.c.) for 4 hr after IVC thrombosis. The weight, inhibition rate, and pathological morphology of the thrombosis induced by IVC ligation and the variation in four coagulation parameters, coagulation factors, and CD61+CD62P+ were simultaneously determined in IVC rats. Results: The thrombus formed as a result of IVC ligation was stable. Compared with the control group, the weight of the thrombus was significantly reduced in the argatroban group. Thrombus weight was reduced by treatment with 0.6, 0.2, and 0.05 mg/kg WV, with inhibition rates of 52.19%, 35.32%, and 28.98%, respectively. Inflammatory cells adhered to and infiltrated the vessel wall in the IVC group more than in the sham group. However, the pathological morphology and CD61+CD62P+ of the WV treatment groups tended to be normal. Conclusion: We improved the model of IVC thrombosis to be suitable for evaluation of antithrombotic drugs. Our findings demonstrated that WV could inhibit IVC thrombosis associated with reducing coagulation factors V and CD61+CD62p expression in rats. | ||
| کلیدواژهها | ||
| Argatroban؛ Blood coagulation factors؛ Platelet activation؛ Venous thrombosis؛ WV | ||
| مراجع | ||
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