Ahmadi A, Ghanbari H, Soheilian M, Naseri
M. 2009. The effect of HESA-A (natural
drug) on visual acuity in age related
macular degeneration: a randomized
double blind controlled clinical trial. Afr J
Tradit Complement Altern Med, 6: 549-
553.
Akkawi MT, Shehadeh MM, Shams ANA, AlHardan DM, Omar LJ, Almahmoud OH,
Qaddumi JAS. 2019. Incidence and risk
factors of retinopathy of prematurity in
three neonatal intensive care units in
Palestine. BMC Ophthalmol, 19: 189.
Balarastaghi S, Delirrad M, Jafari A, Majidi,
M, Sadeghi M, Zare-Zardini H, Karimi G,
Ghorani-Azam A. 2022. Potential benefits
versus hazards of herbal therapy during
pregnancy; a systematic review of
available literature. Phytother Res, 36:
824-841.
Benzie IF, Chung WY, Wang J, Richelle M,
Bucheli P. 2006. Enhanced bioavailability
of zeaxanthin in a milk-based formulation
of wolfberry (Gou Qi Zi; Fructus
barbarum L.). Br J Nutr, 96: 154-160.
Berry S, Lin WV, Sadaka A, Lee AG. 2017.
Nonarteritic anterior ischemic optic
neuropathy: cause, effect, and
management. Eye Brain, 9: 23-28.
Breithaupt DE, Weller P, Wolters M, Hahn A.
2004. Comparison of plasma responses in
human subjects after the ingestion of
3R,3R'-zeaxanthin dipalmitate from
wolfberry (Lycium barbarum) and nonesterified 3R,3R'-zeaxanthin using chiral
high-performance liquid chromatography.
Br J Nutr, 91: 707-713.
Bucheli P, Vidal K, Shen, L, Gu Z, Zhang C,
Miller LE, Wang J . 2011. Goji berry
effects on macular characteristics and
plasma antioxidant levels. Optom Vis Sci,
88: 257-262.
Chan HH, Lam HI, Choi KY, Li SZ,
Lakshmanan Y, Yu WY, Chang RC, Lai
JS, So KF. 2019. Delay of cone
degeneration in retinitis pigmentosa using
a 12-month treatment with Lycium
barbarum supplement. J Ethnopharmacol,
236: 336-344.
Cheng CY, Chung WY, Szeto YT, Benzie IF.
2005. Fasting plasma zeaxanthin response
to Fructus barbarum L. (wolfberry; Kei
Tze) in a food-based human
supplementation trial. Br J Nutr, 93: 123-
130.
Chous AP, Richer SP, Gerson JD, Kowluru
RA. 2016. The diabetes visual function
supplement study (DiVFuSS). Br J
Ophthalmol, 100: 227-234.
Chu WK, Cheung SCM, Lau RAW, Benzie
IFF. 2011. Bilberry (Vaccinium myrtillus
L.). In: Benzie IFF, Wachtel-Galor S
(Eds.), Herbal Medicine, Biomolecular
and Clinical Aspects. pp. 14-16, Boca
Raton CRC Press/Taylor & Francis.
Copyright © 2011 by Taylor and Francis
Group, LLC., Boca Raton (FL).
Domanico D, Fragiotta S, Cutini A, Carnevale
C, Zompatori L, Vingolo EM. 2015.
Circulating levels of reactive oxygen
species in patients with nonproliferative
diabetic retinopathy and the influence of
antioxidant supplementation: 6-month
follow-up. Indian J Ophthalmol, 63: 9-14.
Evans JR. 2000. Ginkgo biloba extract for agerelated macular degeneration. Cochrane
Database Syst Rev, Cd001775: 4-7.
Falsini B, Piccardi M, Minnella A, Savastano
C, Capoluongo E, Fadda A, Balestrazzi E,
Maccarone R, Bisti S. 2010. Influence of
saffron supplementation on retinal flicker
sensitivity in early age-related macular
degeneration. Invest Ophthalmol Vis Sci,
51: 6118-6124.
Fernández-Albarral JA, de Hoz R, Ramírez
AI, López-Cuenca I, Salobrar-García E,
Pinazo-Durán MD, Ramírez JM, Salazar
JJ. 2020. Beneficial effects of saffron
Ansari-Mohseni et al.
AJP, Vol. 13, No. 2, Mar-Apr 2023 140
(Crocus sativus L.) in ocular pathologies,
particularly neurodegenerative retinal
diseases. Neural Regen Res, 15: 1408-
1416.
Forte R, Cennamo G, Finelli ML, Bonavolontà
P, de Crecchio G, Greco GM. 2011.
Combination of flavonoids with Centella
asiatica and Melilotus for diabetic cystoid
macular edema without macular
thickening. J Ocul Pharmacol Ther, 27:
109-113.
Ghorani-Azam A, Sepahi S, Khodaverdi E,
Mohajeri SA. 2018. Herbal medicine as a
promising therapeutic approach for the
management of vascular dementia: a
systematic literature review. Phytother
Res, 32: 1720-1728.
Hamel C. 2006. Retinitis pigmentosa.
Orphanet J Rare Dis, 1: 40-40.
Isobe H, Yamamoto K, Cyong JC. 2003.
Effects of hachimi-jio-gan (ba-wei-dihuang-wan) on blood flow in the human
central retinal artery. Am J Chin Med, 31:
425-435.
Jin M, Dai H, Zhang X, Wang Y, Han M,
Zhang H, Liu Y, Wang Z, Gao X, Li L,
Wen X, Liu Y, Wei L, Chen Y. 2018. A
traditional chinese patent medicine
ZQMT for neovascular age- related
macular degeneration: a multicenter
randomized clinical trial. Curr Mol Med,
18: 622-629.
Jun JJ, Duker JS, Baumal CR, McCabe F,
Reichel E, Rogers AH, Seddon JM,
Tolentino FI. 2010. Cystoid macular
edema without macular thickening: a
retrospective optical coherence
tomographic study. Retina, 30: 917-923.
Karimi A, Majlesi M, Rafieian-Kopaei M.
2015. Herbal versus synthetic drugs;
beliefs and facts. J Nephropharmacol, 4:
27-30.
Katsi V, Marketou M, Vlachopoulos C,
Tousoulis D, Souretis G, Papageorgiou N,
Stefanadis C, Vardas P, Kallikazaros I.
2012. Impact of arterial hypertension on
the eye. Curr Hypertens Rep, 14: 581-
590.
Kumar S, Mittal A, Babu D, Mittal A. 2021.
Herbal medicines for diabetes
management and its secondary
complications. Curr Diabetes Rev, 17:
437-456.
Landau K, Kurz-Levin M. 2011. Retinal
disorders. Handb Clin Neurol, 102: 97-
116.
Lechner J, O'Leary OE, Stitt AW. 2017. The
pathology associated with diabetic
retinopathy. Vision Res, 139: 7-14.
Lian F, Wu L, Tian J, Jin M, Zhou S, Zhao M,
Wei L, Zheng Y, Wang Y, Zhang M, Qin
W, Wu Z, Yuan CS, Tong X. 2015. The
effectiveness and safety of a danshencontaining chinese herbal medicine for
diabetic retinopathy: a randomized,
double-blind, placebo-controlled
multicenter clinical trial. J
Ethnopharmacol, 164: 71-77.
Liu J, Li S, Sun D. 2019. Calcium dobesilate
and micro-vascular diseases. Life Sci,
221: 348-353.
Luo D, Deng T, Yuan W, Deng H, Meng H,
Jin M. 2019. Effects of Huangban
Bianxing one decoction combined with
ranibizumab on treating exudative agerelated macular degeneration. J Tradit
Chin Med, 39: 892-901.
Luo D, Qin Y, Yuan W, Deng H, Zhang Y, Jin
M. 2015. Compound danshen dripping
pill for treating early diabetic retinopathy:
a randomized, double-dummy, doubleblind study. Evid Based Complement
Alternat Med, 2015: 539185.
Luo XX, Duan JG, Liao PZ, Wu L, Yu YG,
Qiu B, Wang YL, Li YM, Yin ZQ, Liu X,
Yao K. 2009. Effect of qiming granule on
retinal blood circulation of diabetic
retinopathy: a multicenter clinical trial.
Chin J Integr Med, 15: 384-388.
Marangoni D, Falsini B, Piccardi M,
Ambrosio L, Minnella AM, Savastano
MC, Bisti S, Maccarone R, Fadda A,
Mello E, Concolino P, Capoluongo E.
2013. Functional effect of Saffron
supplementation and risk genotypes in
early age-related macular degeneration: a
preliminary report. J Transl Med, 11: 228.
Mazzolani F, Togni S, Giacomelli L,
Eggenhoffner R, Franceschi F. 2018. Oral
administration of a curcuminphospholipid formulation (Meriva®) for
treatment of chronic diabetic macular
edema: a pilot study. Eur Rev Med
Pharmacol Sci, 22: 3617-3625.
Mitchell P, Liew G, Gopinath B, Wong TY.
2018. Age-related macular degeneration.
Lancet, 392: 1147-1159.
Moon SW, Shin YU, Cho H, Bae SH, Kim
HK. 2019. Effect of grape seed
proanthocyanidin extract on hard
Herbal medicines in retinopathy
AJP, Vol. 13, No. 2, Mar-Apr 2023 141
exudates in patients with non-proliferative
diabetic retinopathy. Medicine
(Baltimore), 98: e15515.
Nentwich MM, Ulbig MW. 2015. Diabetic
retinopathy - ocular complications of
diabetes mellitus. World J Diabetes, 6:
489-499.
Osada H, Okamoto T, Kawashima H, Toda E,
Miyake S, Naga N, Kobayashi S, Tsubota
K, Ozawa Y. 2017. Neuroprotective
effect of bilberry extract in a murine
model of photo-stressed retina. PLoS
One, 12: e0178627.
Pan HT, Wang JJ, Huang JL, Shuai YL, Li J,
Hu ZZ, Ding YZ, Liu QH. 2020.
Ranibizumab plus fufang xueshuantong
capsule versus ranibizumab alone for
exudative age-related macular
degeneration. J Int Med Res, 48:
0300060520931618.
Park YG, Roh YJ. 2016. New diagnostic and
therapeutic approaches for preventing the
progression of diabetic retinopathy. J
Diabetes Res, 2016: 1753584.
Penn JS, Madan A, Caldwell RB, Bartoli M,
Caldwell RW, Hartnett ME. 2008.
Vascular endothelial growth factor in eye
disease. Prog Retin Eye Res, 27: 331-371.
Petri AS, Boysen K, Cehofski LJ, van Dijk
EHC, Dysli C, Fuchs J, Mastropasqua R,
Subhi Y. 2020. Intravitreal injections with
vascular endothelial growth factor
inhibitors: a practical approach.
Ophthalmol Ther, 9: 191-203.
Piccardi M, Fadda A, Martelli F, Marangoni
D, Magli A, Minnella AM, Bertelli M, Di
Marco S, Bisti S, Falsini B. 2019.
Antioxidant saffron and central retinal
function in ABCA4-related stargardt
macular dystrophy. Nutrients, 11: 2461.
Piccardi M, Marangoni D, Minnella AM,
Savastano MC, Valentini P, Ambrosio L,
Capoluongo E, Maccarone R, Bisti S,
Falsini B. 2012. A longitudinal follow-up
study of saffron supplementation in early
age-related macular degeneration:
sustained benefits to central retinal
function. Evid Based Complement
Alternat Med, 2012: 429124.
Rath EZ, Hazan Z, Adamsky K, Solomon A,
Segal ZI, Levin LA. 2019. Randomized
controlled phase 2a study of RPh201 in
previous nonarteritic anterior ischemic
optic neuropathy. J Neuroophthalmol, 39:
291-298.
Rota R, Chiavaroli C, Garay RP, Hannaert P.
2004. Reduction of retinal albumin
leakage by the antioxidant calcium
dobesilate in streptozotocin-diabetic rats.
Eur J Pharmacol, 495: 217-224.
Salz DA, Witkin AJ. 2015. Imaging in diabetic
retinopathy. Middle East Afr J
Ophthalmol, 22: 145-150.
Sankar MJ, Sankar J, Chandra P. 2018. Antivascular endothelial growth factor
(VEGF) drugs for treatment of
retinopathy of prematurity. Cochrane
Database Syst Rev, 2018: CD009734.
Sepahi S, Mohajeri SA, Hosseini SM,
Khodaverdi E, Shoeibi N, Namdari M,
Tabassi SAS. 2018. Effects of crocin on
diabetic maculopathy: a placebocontrolled randomized clinical trial. Am J
Ophthalmol, 190: 89-98.
Sofowora A, Ogunbodede E, Onayade A.
2013. The role and place of medicinal
plants in the strategies for disease
prevention. Afr J Tradit Complement
Altern Med, 10: 210-229.
Spadea L, Balestrazzi E. 2001. Treatment of
vascular retinopathies with Pycnogenol.
Phytother Res, 15: 219-223.
Steigerwalt R, Belcaro G, Cesarone MR, Di
Renzo A, Grossi MG, Ricci A, Dugall M,
Cacchio M, Schönlau F. 2009.
Pycnogenol improves microcirculation,
retinal edema, and visual acuity in early
diabetic retinopathy. J Ocul Pharmacol
Ther, 25: 537-540.
Steigerwalt R, Nebbioso M, Appendino G,
Belcaro G, Ciammaichella G, Cornelli U,
Luzzi R, Togni S, Dugall M, Cesarone
MR, Ippolito E, Errichi BM, Ledda A,
Hosoi M, Corsi M. 2012. Meriva®, a
lecithinized curcumin delivery system, in
diabetic microangiopathy and retinopathy.
Panminerva Med, 54: 11-16.
Tarr JM, Kaul K, Chopra M, Kohner EM,
Chibber R. 2013. Pathophysiology of
diabetic retinopathy. ISRN Ophthalmol,
2013: 343560.
Tsang SH, Sharma T. 2018. Stargardt disease.
Adv Exp Med Biol, 1085: 139-151.
Vasant More S, Kim IS, Choi DK. 2017.
Recent update on the role of chinese
material medica and formulations in
diabetic retinopathy. Molecules, 22: 76.
Xu ZH, Gao YY, Zhang HT, Ruan KF, Feng
Y. 2018. Progress in experimental and
clinical research of the diabetic
Ansari-Mohseni et al.
AJP, Vol. 13, No. 2, Mar-Apr 2023 142
retinopathy treatment using traditional
chinese medicine. Am J Chin Med: 1-27.
Zhang HW, Zhang H, Grant SJ, Wan X, Li G.
2018. Single herbal medicine for diabetic
retinopathy. Cochrane Database Syst Rev,
12: CD007939.
Zhao Y, Singh RP. 2018. The role of antivascular endothelial growth factor (antiVEGF) in the management of
proliferative diabetic retinopathy. Drugs
Context, 7: 212532.
Zhao Y, Yu J, Liu J, An X. 2016. The role of
Liuwei Dihuang Pills and Ginkgo leaf
tablets in treating diabetic complications.
Evid Based Complement Alternat Med,
2016: 7931314.
Zhao Y, Yu X, Lou Y, Sun X, Zhu B, Xu W,
Zhou L, Wu H, Jin Q, Wang H, Shen J,
Yu J, An X. 2020. Therapeutic effect of
abelmoschus manihot on type 2 diabetic
nonproliferative retinopathy and the
involvement of VEGF. Evid Based
Complement Alternat Med, 2020:
5204917.
Zhu X, Bi A, Han X. 2002. Treatment of
retinal vein obstruction with acupuncture
and Chinese medicinal herbs. J Tradit
Chin Med, 22: 211-213