سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Zia, Atousa, Rezaei Aghdam, Hakimeh, Saffari, Mostafa, Farzaneh, Jafar, Pirali Hamedani, Morteza, Ebrahimi, Seyed Esmaeil Sadat, Abdollahi, Kimia, Sedigh Kheirabad, Saghar, Zarringhalam, Fatemeh, Davachi omoomi, Farnoor, Farhoudi, Ramin, Shafiee Ardestani, Mehdi. (1401). Novel chitosan-quinic acid nanoparticles labeled with m99 technetium for breast cancer imaging. , 9(3), 231-240. doi: 10.22038/nmj.2022.64517.1673
Atousa Zia; Hakimeh Rezaei Aghdam; Mostafa Saffari; Jafar Farzaneh; Morteza Pirali Hamedani; Seyed Esmaeil Sadat Ebrahimi; Kimia Abdollahi; Saghar Sedigh Kheirabad; Fatemeh Zarringhalam; Farnoor Davachi omoomi; Ramin Farhoudi; Mehdi Shafiee Ardestani. "Novel chitosan-quinic acid nanoparticles labeled with m99 technetium for breast cancer imaging". , 9, 3, 1401, 231-240. doi: 10.22038/nmj.2022.64517.1673
Zia, Atousa, Rezaei Aghdam, Hakimeh, Saffari, Mostafa, Farzaneh, Jafar, Pirali Hamedani, Morteza, Ebrahimi, Seyed Esmaeil Sadat, Abdollahi, Kimia, Sedigh Kheirabad, Saghar, Zarringhalam, Fatemeh, Davachi omoomi, Farnoor, Farhoudi, Ramin, Shafiee Ardestani, Mehdi. (1401). 'Novel chitosan-quinic acid nanoparticles labeled with m99 technetium for breast cancer imaging', , 9(3), pp. 231-240. doi: 10.22038/nmj.2022.64517.1673
Zia, Atousa, Rezaei Aghdam, Hakimeh, Saffari, Mostafa, Farzaneh, Jafar, Pirali Hamedani, Morteza, Ebrahimi, Seyed Esmaeil Sadat, Abdollahi, Kimia, Sedigh Kheirabad, Saghar, Zarringhalam, Fatemeh, Davachi omoomi, Farnoor, Farhoudi, Ramin, Shafiee Ardestani, Mehdi. Novel chitosan-quinic acid nanoparticles labeled with m99 technetium for breast cancer imaging. , 1401; 9(3): 231-240. doi: 10.22038/nmj.2022.64517.1673

Novel chitosan-quinic acid nanoparticles labeled with m99 technetium for breast cancer imaging

Nanomedicine Journal
مقاله 6، دوره 9، شماره 3، مهر 2022، صفحه 231-240    اصل مقاله (1.12 M)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22038/nmj.2022.64517.1673
نویسندگان
Atousa Zia1؛ Hakimeh Rezaei Aghdam2؛ Mostafa Saffari1؛ Jafar Farzaneh2؛ Morteza Pirali Hamedani3؛ Seyed Esmaeil Sadat Ebrahimi4؛ Kimia Abdollahi2؛ Saghar Sedigh Kheirabad2؛ Fatemeh Zarringhalam2؛ Farnoor Davachi omoomi2؛ Ramin Farhoudi4؛ Mehdi Shafiee Ardestani* 2
1Faculty of Pharmacy, Islamic Azad University, Tehran, Iran
2Department of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
3Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
4Pasteur Institute of Iran
چکیده
Objective(s): Today, cancer is one of the health concerns in modern societies. The use of nanoparticles in medical science has created new possibilities for diagnosis, imaging of tumors, and treatment of cancer in humans. 
Materials and Methods: In this study, chitosan nanoparticles modified with quinic acid were used to diagnose breast cancer using a single-photon emission computed tomography imaging technique. For this purpose, quinic acid was activated by EDC/NHS and then binding was performed by adding chitosan nanoparticles. 
Results: TEM, DLS, FTIR, and LC/MASS analyzes were used to investigate this conjugation. MTT toxicity test showed no toxicity on the HEK-293 cell lines and therapeutic properties for the MCF-7 cell line. The response surface method depends on the central composite design that was applied. For the highest labeling efficiency, using 3 factors: the amount of chitosan-quinic acid, pH, and SnCl2 as a reducing agent, and the efficiency of labeling was evaluated by thin-layer chromatography (TLC). 
Conclusion: Finally, the study of biodistribution using SPECT imaging in cancer mice and its comparison with blocking tests showed that this compound has a good ability to diagnose breast cancer.
کلیدواژه‌ها
Blocking؛ Breast cancer؛ Chitosan؛ Quinic acid؛ SPECT imaging
مراجع
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