Development of eucalyptol enriched nano vesicles for better transdermal delivery of curcumin: Preparation, characterisation and ex vivo skin analysis | ||
| Nanomedicine Journal | ||
| مقاله 5، دوره 9، شماره 3، مهر 2022، صفحه 223-230 اصل مقاله (667.15 K) | ||
| نوع مقاله: Research Paper | ||
| شناسه دیجیتال (DOI): 10.22038/nmj.2022.65785.1689 | ||
| نویسندگان | ||
| Bhumika Kumar* ؛ Pravat Kumar Sahoo؛ Satish Manchanda | ||
| Department of Pharmaceutics, Delhi institute of Pharmaceutical Sciences and Research, Delhi Pharmaceutical Sciences and Research University (DPSRU) Pushp Vihar Sector III, MB Road, New Delhi- 110017 (INDIA) New Delhi | ||
| چکیده | ||
| Objective(s): Invasomes are nano-sized vesicular systems made of ethanol, soybean phosphatidylcholine and terpenes that promote skin penetration by disrupting the lipoidal structure of stratum corneum, interacting with the matrix proteins and augmenting the partitioning of the drug moiety in the skin layer. Curcumin is a well-known bright yellow coloured polyphenol which is produced by the plants of curcuma long class belonging to family Zingiberaceae. It is being used in the therapeutic field since ancient times for the treatment of several diseases. It is a complex molecule with substantial activity against a number of ailments. Despite having a number of health benefits, curcumin’s limited water solubility and poor skin penetration are the major barriers in its transdermal application. Materials and Methods: In present research work, terpenoid invasomal nano vesicles of curcumin were prepared using mechanical dispersion process with eucalyptol as the permeation enhancer. The prepared invasomal formulations were characterised and optimised in terms of entrapment efficiency, vesicle size, in vitro drug release, ex vivo permeation and skin retention analysis. Results: The transmission electron microscope confirmed the presence of spherical-shaped vesicles with a vesicle size of 461.57± 1.38 nm and 80.54 ± 0.38 % entrapment efficiency. In vitro release kinetics conformed well with Higuchi kinetic model for release. Ex vivo study confirmed that the curcumin permeation across the pig ear skin from the optimised formulation was 2.5 times higher than curcumin solution and had a flux of 179.44±0.26 µg/cm2/h. Conclusion: The study suggests that invasomes have a high potential for transdermal administration of curcumin which can increase the topical utility of curcumin in several skin diseases. | ||
| کلیدواژهها | ||
| Invasomes؛ Permeation enhancer؛ Skin؛ Terpene | ||
| مراجع | ||
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1. Hewlings SJ, Kalman DS. Curcumin: A Review of Its Effects on Human Health. Foods. 2017;6(10):92. 2. Panahi Y, Fazlolahzadeh O, Atkin SL. Evidence of curcumin and curcumin analogue effects in skin diseases: A narrative review. J Cell Physiol. 2019;234; 2:1165-1178. 3. Sun L, Liu Z, Wang L. Enhanced topical penetration, system exposure and anti-psoriasis activity of two particle-sized, curcumin-loaded PLGA nanoparticles in hydrogel. J Control Release. 2017;254:44-54. 4. Kang D, Li B, Luo L. Curcumin shows excellent therapeutic effect on psoriasis in mouse model. Biochimie. 2016;123:73-80. 5. Kulac M, Aktas C, Tulubas F. The effects of topical treatment with curcumin on burn wound healing in rats. J Mol Histol. 2013;44(1):83-90. 6. Partoazar A, Kianvash N, Darvishi MH, Nasoohi S, Rezayat SM, Bahador A. Ethosomal Curcumin Promoted Wound Healing and Reduced Bacterial Flora in Second Degree Burn in Rat. Drug Res (Stuttg). 2016;66(12):660-665. 7. Dragicevic N, Verma DD, Fahr A. Invasomes: Vesicles for enhanced skin delivery of drugs. In: Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement: Nanocarriers. Springer Berlin Heidelberg. 2016;77–92. 8. Lakshmi PK, Kalpana B, Prasanthi D. Invasomes-novel vesicular carriers for enhanced skin permeation. Sys Rev Pharm. 2013;4(1):26-30. 9. Chen J, Jiang QD, Chai YP, Zhang H, Peng P, Yang XX. Natural Terpenes as Penetration Enhancers for Transdermal Drug Delivery. Molecules. 2016;21(12):1709. 10. Babaie S, Bakhshayesh ARD, Ha JW, Hamishehkar H, Kim KH. Invasome: A Novel Nanocarrier for Transdermal Drug Delivery. Nanomaterials. 2020;10(2):341. 11. Dragicevic-Curic N, Scheglmann D, Albrecht V, Fahr A. Temoporfin-loaded invasomes: development, characterization and in vitro skin penetration studies. J Control Release. 2008;127(1):59-69. 12. Kamran M, Ahad A, Aqil M, Imam SS, Sultana Y, Ali A. Design, formulation and optimization of novel soft nano-carriers for transdermal olmesartan medoxomil delivery: In vitro characterization and in vivo pharmacokinetic assessment. Int J Pharm. 2016;505(1-2):147-158. 13. Kumar MY. Preparation and Evaluation of Curcumin Invasomes. Int. J. Drug Deliv. 2014; 6(2):113-120. 14. Dragicevic-Curic N, Gräfe S, Gitter B, Fahr A. Efficacy of temoporfin-loaded invasomes in the photodynamic therapy in human epidermoid and colorectal tumour cell lines. J Photochem Photobiol B. 2010;101(3):238-250. 15. Shamma RN, Aburahma MH. Follicular delivery of spironolactone via nanostructured lipid carriers for management of alopecia. Int J Nanomedicine. 2014;9:5449-5460. 16. Aggarwal D, Kaur IP. Improved pharmacodynamics of timolol maleate from a mucoadhesive niosomal ophthalmic drug delivery system. Int J Pharm. 2005;290(1-2):155-159. 17. Amnuaikit T, Limsuwan T, Khongkow P, Boonme P. Vesicular carriers containing phenylethyl resorcinol for topical delivery system; liposomes, transfersomes and invasomes. Asian J Pharm Sci. 2018;13(5):472-484. 18. Manchanda S, Sahoo PK. Fabrication and characterization of mucoadhesive topical nanoformulations of dorzolamide HCl for ocular hypertension. J Pharm Investig. 2018;48: 323–332. 19. Kumar B, Sahoo PK, Manchanda S. Curcumin Loaded Ethosomal Gel for Improved Topical Delivery: Formulation, Characterization and Ex-vivo Studies. Pharm Nanotechnol. 2021;9(4):281-287. 20. Qadri GR, Ahad A, Aqil M, Imam SS, Ali A. Invasomes of isradipine for enhanced transdermal delivery against hypertension: formulation, characterization, and in vivo pharmacodynamic study. Artif Cells Nanomed Biotechnol. 2017;45(1):139-145. 21. Chandra A, Aggarwal G, Manchanda S, Narula A. Development of Topical Gel of Methotrexate Incorporated Ethosomes and Salicylic Acid for the Treatment of Psoriasis. Pharm Nanotechnol. 2019;7(5):362-374. 22. Paolino D, Lucania G, Mardente D, Alhaique F, Fresta M. Ethosomes for skin delivery of ammonium glycyrrhizinate: in vitro percutaneous permeation through human skin and in vivo anti-inflammatory activity on human volunteers. J Control Release. 2005;106(1-2):99-110. 23. Ashok A Hajare, Mahesh N Mali, Sushil Sarvagod, Sachin Kurane, Shweta Patwardhan, Arun S. Dange, Adsorption and partition studies of fluconazole. Asian J Res Chem. 2009;2(2):213-219. 24. Sujitha B, Krishnamoorthy B, Muthukumaran M. Formulation and evaluation of piroxicam loaded ethosomal gel for transdermal delivery. Int J Adv Pharm Gen Res. 2014;2:34-45. 25. Algahtani MS, Ahmad MZ, Ahmad J. Nanoemulsion loaded polymeric hydrogel for topical delivery of curcumin in psoriasis. J Drug Deliv Sci Technol. 2020;1(59):101847. 26. Li G, Fan Y, Fan C, et al. Tacrolimus-loaded ethosomes: physicochemical characterization and invivo evaluation. Eur J Pharm Biopharm 2012;82(1):49-57. 27. Vidya K, Lakshmi PK. Cytotoxic effect of transdermal invasomal anastrozole gel on MCF-7 breast cancer cell line. J Appl Pharm Sci. 2019;9(3):50–58. | ||
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