Hosseiniravesh, Mohammad Reza, Hojati, Vida, Khajavirad, Abolfazl, Shajiee, Hooman, Shafei, Mohammad Naser, Mohebbati, Reza. (1401). Effect of MK-801, an antagonist of NMDA receptor in the pedunculopontine tegmental nucleus, on cardiovascular parameters in normotensive and hydralazine hypotensive rats. , 25(5), 569-576. doi: 10.22038/ijbms.2022.62431.13809
Mohammad Reza Hosseiniravesh; Vida Hojati; Abolfazl Khajavirad; Hooman Shajiee; Mohammad Naser Shafei; Reza Mohebbati. "Effect of MK-801, an antagonist of NMDA receptor in the pedunculopontine tegmental nucleus, on cardiovascular parameters in normotensive and hydralazine hypotensive rats". , 25, 5, 1401, 569-576. doi: 10.22038/ijbms.2022.62431.13809
Hosseiniravesh, Mohammad Reza, Hojati, Vida, Khajavirad, Abolfazl, Shajiee, Hooman, Shafei, Mohammad Naser, Mohebbati, Reza. (1401). 'Effect of MK-801, an antagonist of NMDA receptor in the pedunculopontine tegmental nucleus, on cardiovascular parameters in normotensive and hydralazine hypotensive rats', , 25(5), pp. 569-576. doi: 10.22038/ijbms.2022.62431.13809
Hosseiniravesh, Mohammad Reza, Hojati, Vida, Khajavirad, Abolfazl, Shajiee, Hooman, Shafei, Mohammad Naser, Mohebbati, Reza. Effect of MK-801, an antagonist of NMDA receptor in the pedunculopontine tegmental nucleus, on cardiovascular parameters in normotensive and hydralazine hypotensive rats. , 1401; 25(5): 569-576. doi: 10.22038/ijbms.2022.62431.13809

Effect of MK-801, an antagonist of NMDA receptor in the pedunculopontine tegmental nucleus, on cardiovascular parameters in normotensive and hydralazine hypotensive rats

Iranian Journal of Basic Medical Sciences
مقاله 4، دوره 25، شماره 5، مرداد 2022، صفحه 569-576    اصل مقاله (672.07 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2022.62431.13809
نویسندگان
Mohammad Reza Hosseiniravesh1؛ Vida Hojati1؛ Abolfazl Khajavirad2؛ Hooman Shajiee1؛ Mohammad Naser Shafei* 3، 4؛ Reza Mohebbati2، 3
1Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran
2Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
3Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
4Division of Neurocognitive Sciences, Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده
Objective(s): In the present study, the cardiovascular effects of glutamate NMDA receptor of the pedunculopontine tegmental nucleus (PPT) in normotensive and hydralazine (HLZ) hypotensive rats were evaluated. 
Materials and Methods: In the normotensive condition, MK-801(1 nmol; an NMDA receptor antagonist) and L-glutamate (L-Glu, 50 nmol an agonist) alone and together were microinjected into the nucleus using a stereotaxic device. In hypotensive condition, 2 min after induction of hypotension by HLZ (10 mg/kg, intravenous), drugs, same as in normotensive condition, were microinjected into the PPT. Recorded mean arterial pressure (MAP), systolic blood pressure (SBP), and heart rate (HR) were recorded throughout the experiment by a Power lab apparatus that was connected to a catheter inserted into the femoral arty. The cardiovascular changes (Δ) induced by microinjection drugs were computed and statistically analyzed.
Results: In the normotensive condition, L-Glu significantly increased ΔMAP and ΔSBP (P<0.001) and decreased ΔHR (P<0.01) compared with the control. MK-801 alone significantly increased HR (P<0.05) while co-injected with L-Glu + MK-801 it significantly attenuated the L-Glu effect on ΔMAP and ΔSBP but augmented ΔHR (P<0.01). In the hydralazine hypotension condition, L-Glu significantly improved hypotension (P<0.01) and deteriorated bradycardia induced by HLZ (P<0.05). MK-801 alone did not significantly affect ΔMAP, ΔSBP, and ΔHR but when co-injected with L-Glu (L-Glu + MK-801) it could significantly attenuate the cardiovascular effect of L-Glu in the PPT. 
Conclusion: We found that activation of NMDA receptors of the glutamatergic system in the PPT evoked blood pressure and inhibited HR in both normotensive and hypotensive conditions in rats. 
کلیدواژه‌ها
Blood pressure؛ Glutamate؛ Hypotension؛ NMDA receptor؛ Pedunculopontine tegmental nucleus
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