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Keivanfar, Majid, Allameh, zahra, Nasri, Peiman, Reisi, Mohsen, Korki, Amir Arsalan. (1401). Evaluation of Proper Prescription of Antacid Agents in a Group of Critically Ill Children Admitted to PICU in 2018-2019. , 10(9), 16656-16665. doi: 10.22038/ijp.2022.62809.4796
Majid Keivanfar; zahra Allameh; Peiman Nasri; Mohsen Reisi; Amir Arsalan Korki. "Evaluation of Proper Prescription of Antacid Agents in a Group of Critically Ill Children Admitted to PICU in 2018-2019". , 10, 9, 1401, 16656-16665. doi: 10.22038/ijp.2022.62809.4796
Keivanfar, Majid, Allameh, zahra, Nasri, Peiman, Reisi, Mohsen, Korki, Amir Arsalan. (1401). 'Evaluation of Proper Prescription of Antacid Agents in a Group of Critically Ill Children Admitted to PICU in 2018-2019', , 10(9), pp. 16656-16665. doi: 10.22038/ijp.2022.62809.4796
Keivanfar, Majid, Allameh, zahra, Nasri, Peiman, Reisi, Mohsen, Korki, Amir Arsalan. Evaluation of Proper Prescription of Antacid Agents in a Group of Critically Ill Children Admitted to PICU in 2018-2019. , 1401; 10(9): 16656-16665. doi: 10.22038/ijp.2022.62809.4796

Evaluation of Proper Prescription of Antacid Agents in a Group of Critically Ill Children Admitted to PICU in 2018-2019

Journal of Pediatric Perspectives
مقاله 5، دوره 10، شماره 9، آذر 2022، صفحه 16656-16665    اصل مقاله (428.09 K)
نوع مقاله: original article
شناسه دیجیتال (DOI): 10.22038/ijp.2022.62809.4796
نویسندگان
Majid Keivanfar1؛ zahra Allameh2؛ Peiman Nasri3؛ Mohsen Reisi* 4؛ Amir Arsalan Korki5
11.Department of Pediatric Pulmonology, Pediatrics Department, Imam Hossein children's hospital, Isfahan University of Medical Sciences, Isfahan, Iran. 2. Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.
2Department of Clinical Pharmacy and Pharmacy Practice, Isfahan University of Medical Sciences, Isfahan, Iran
31.Department of Pediatric Pulmonology, Pediatrics Department, Imam Hossein children's hospital, Isfahan University of Medical Sciences, Isfahan, Iran. 2. Pediatrics Department, Imam Hossein children's hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
41. Department of Pediatric Pulmonology, Pediatrics Department, Imam Hossein children's hospital, Isfahan University of Medical Sciences, Isfahan, Iran. 2. 2 Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.
5Pediatrics Department, Imam Hossein children's hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
چکیده
Background: Critically ill patients, especially those requiring admission to intensive care units (ICU), are at risk for stress-related gastrointestinal mucosal damage. We aimed to evaluate the frequency of proper prescription of antacid agents in a group of critically ill children admitted to PICU.
Methods: In this retrospective study, the medical records of children aged between 1 month and 15 years who were admitted in 2018-2019 to the PICU of Imam Hossein children's hospital, Isfahan, Iran, were reviewed. Demographic data, indications for PICU admission, principal diagnosis, the severity of the disease, incidence of bleeding during hospitalization, indications for stress ulcer prophylaxis, prescription of the antacid agents, type of antacid prescribed, and the patient's final outcome were recorded. All the data were gathered and organized by a medical intern. We calculated the rate of the patients who were indicated for SUP, those who were not indicated for SUP (Stress Ulcer Prophylaxis), those who received SUP (Stress Ulcer Prophylaxis), and those who did not receive SUP. Data analysis was performed with the Statistical Package for the Social Sciences software (SPSS, version 24.0, IBM, Armonk, New York).
Results: We found that 204 (92.7%) of our patients received antacid agents for gastric SUP. Among the patients receiving SUP, 198 (90%) had an indication for SUP, and only 6 (2.7%) cases received unnecessary prophylaxis? In addition, 16 (7.2%) patients had no indication of receiving SUP and did not receive any prophylaxis. We also reviewed the type of antacid medication that was prescribed for SUP and found that 157 (72%) patients had received PPI, and 57 (30%) had received H2Ras.
Conclusions: The findings of the current study revealed that almost all of our study population who had an indication for prophylaxis of stress ulcer appropriately received antacid agents. We suggest that there is a crucial need to conduct large prospective and multicentric studies in pediatric centers to prepare a universally accepted guideline for the prophylaxis of stress ulcers in the pediatric age group.
کلیدواژه‌ها
Anti acids؛ pediatric؛ intensive care units
مراجع
  1. Reveiz L, Guerrero‐Lozano R, Camacho A, Yara L, Mosquera PA. Stress ulcer, gastritis, and gastrointestinal bleeding prophylaxis in critically ill pediatric patients: a systematic review. Pediatr Crit Care Med. 2010; 11:124‐132.
  2. Marik PE, Vasu T, Hirani A, Pachinburavan M. Stress ulcer prophylaxis in the new millennium: a systematic review and meta‐analysis. Crit Care Med. 2010; 38:2222‐2228.
  3. Lugo RA, Harrison AM, Cash J, Sweeley J, Vernon DD. Pharmacokinetics and pharmacodynamics of ranitidine in critically ill children. Crit Care Med. 2001: 29: 759-64.
  4. Cook D, Heyland D, Griffith L, Cook R, Marshall J, Pagliarello J. Risk factors for clinically important upper gastrointestinal bleeding in patients requiring mechanical ventilation. Crit Care Med. Canadian Critical Care Trials Group. 1999; 27: 2812-7.
  5. Deerojanawong J, Peongsujarit D, Vivatvakin B, Prapphal N. Incidence and risk factors of upper gastrointestinal bleeding in mechanically ventilated children. Pediatr Crit Care Med. 2009; 10: 91-5.
  6. Nithiwat Hanapong C, Reungrongrat S, Ukarapol N. Prevalence and risk factors of stress-induced gastrointestinal bleeding in critically ill children. World J Gastroenterol. 2005; 11(43):6839-6842. doi:10.3748/wjg.v11.i43.6839
  7. Chaı̈bou M, Tucci M, Dugas M‐A, Farrell CA, Proulx F, Lacroix J. Clinically significant upper gastrointestinal bleeding acquired in a pediatric intensive care unit: a prospective study. Pediatrics. 1998; 102:933‐938.
  8. Cook D, Heyland D, Griffith L, Cook R, Marshall J, Pagliarello J. Risk factors for clinically important upper gastrointestinal bleeding in patients requiring mechanical ventilation. Crit Care Med. Canadian Critical Care Trials Group. 1999; 27: 2812-7.
  9. Gauvin F, Dugas MA, Chaïbou M, Morneau S, Lebel D, Lacroix J. The impact of clinically significant upper gastrointestinal bleeding acquired in a pediatric intensive care unit. Pediatr Crit Care Med. 2001; 2:294–8. doi: 10.1097/00130478-200110000-00002.
  10. Lacroix J, Nadeau D, Laberge S, Gauthier M, Lapierre G, Farrel CA. Frequency of upper gastrointestinal bleeding in a pediatric intensive care unit. Crit Care Med. 1992; 20: 35-42.
  11. Sahin S, Ayar G, Yazici MU, et al. Stress induced gastrointestinal bleeding in a pediatric intensive care unit: which risk factors should necessitate prophylaxis? Minerva Pediatrica. 2016 Feb; 68(1):19-26.
  12. Pharmacy Department Policies and Procedures, Stanford Hospital and Clinics, Stanford medicine, Stress Ulcer Prophylaxis Clinical Guidelines, 2015, http://med.stanford.edu/bugsanddrugs/guidebook/_jcr_content/main/panel_builder_1454513702/panel_0/download_755553060/file.res/stress_ulcer_prophylaxis_guidelines.pdf
  13. McAlhany J, Colmic L, Czaja AJ, Pruitt B. Antacid control of complications from acute gastroduodenal disease after burns. J Trauma. 1976; 16:645‐648.
  14. Frandah W, Colmer-Hamood J, Nugent K, Raj R. Patterns of use of prophylaxis for stress-related mucosal disease in patients admitted to the intensive care unit. J Intensive Care Med. 2014; 29(2):96-103. DOI: 10.1177/0885066612453542
  15. Costarino AT, Dai D, Feng R, Feudtner C, Guevara JP. Gastric Acid Suppressant Prophylaxis in Pediatric Intensive Care: Current Practice as Reflected in a Large Administrative Database. Pediatr Crit Care Med. 2015; 16(7):605-612. doi:10.1097/PCC.0000000000000427
  16. Krag M, Perner A, Wetterslev J, et al. Prevalence and outcome of gastrointestinal bleeding and use of acid suppressants in acutely ill adult intensive care patients. Intensive Care Med. 2015; 41:833‐845.
  17. Wang Y, Ye Z, Ge L, et al. Efficacy and safety of gastrointestinal bleeding prophylaxis in critically ill patients: systematic review and network meta-analysis. BMJ. 2020; 368:l6744. Published 2020 Jan 6. doi:10.1136/bmj.l6744
  18. Krag M, Marker S, Perner A, et al. SUP-ICU trial group Pantoprazole in patients at risk for gastrointestinal bleeding in the ICU. N Engl J Med 2018; 379:2199-208. 10.1056/NEJMoa1714919
  19. Yildiz Das D, Yapıcıoğlu H, Yilmaz HL. Occurrence of ventilator-associated pneumonia in mechanically ventilated pediatric intensive care patients during stress ulcer prophylaxis with sucralfate, ranitidine, and omeprazole. J Crit Care Elsevier. 2002; 17:240–5. doi: 10.1053/jcrc.2002.36761.
  20. Duffett M, Choong K, Foster J, Gilfoyle E, Lacroix J, Cook DJ. Stress ulcer prophylaxis in critically ill children: A systematic review. World Congress of Pediatric Intensive and Critical Care. Toronto; 2016; PICC-0055.
  21. ASHP Commission on Therapeutics. ASHP therapeutic guidelines on stress ulcer prophylaxis. Am J Health-Syst Pharm. 1999; 56:347-79.
  22. Duffett, M., Chan, A., Closs, J., McGloin, R., McKelvie, G., Pong, S., Seto, W., Slaney, H., Vaninetti, G. and Vanniyasingam, T., 2020. Stress ulcer prophylaxis in critically ill children: A multicenter observational study. Pediatric Critical Care Medicine| Society of Critical Care Medicine, 21(2), pp.e107-e113.
  23. Malhis A, Alghamdi T, Alfandi R, et al. Appropriateness of Acid-suppressing Agents for Stress Ulcer Prophylaxis in Non-intensive Care Unit Setting in Saudi Arabia. J Pharm Bioallied Sci. 2019; 11(1):96-101. doi:10.4103/jpbs.JPBS_173_18
  24. Mohamad MS, Shamsuddin N, Tan KM. Appropriateness of stress ulcer prophylaxis among older adults admitted to general medical wards in a university hospital. Eur Geriatr Med. 2015; 6:119–23.
  25. Qadeer M.A., Richter J.E., and Brotman D.J.: Hospital-acquired gastrointestinal bleeding outside the critical care unit. J Hosp Med 2006; 1: pp. 13-20
  26. Slattery E., Theyventhiran R., Cullen G., et al: Intravenous proton pump inhibitor use in hospital practice. Eur J Gastroenterol Hepatol 2007; 19: pp. 461-464
  27. faBanerjee A, Mbamalu D, Ebrahimi S, Khan AA, Chan TF. The prevalence of polypharmacy in elderly attenders to an emergency department—a problem with a need for an effective solution. Int J Emerg Med. 2011; 4:22. Published 2011 Jun 2. DOI: 10.1186/1865-1380-4-22.
  28. Farrell CP, Mercogliano G, Kuntz CL. Overuse of stress ulcer prophylaxis in the critical care setting and beyond. J Crit Care. 2010; 25(2):214-220. doi:10.1016/j.jcrc.2009.05.014
  29. Rafati M, Karami H, Shiva A, Babazadeh F, Motevallian E. Evaluation of PICU stress ulcer prophylaxis in sari Bu-Ali Sina Hospital. Journal of Mazandaran University of Medical Sciences. 2016; 25(134):33-42.
  30. Cook DJ, Reeve BK, Guyatt GH, et al. Stress ulcer prophylaxis in critically ill patients. Resolving discordant meta-analyses. JAMA 1996; 275:308.
  31. Bateman BT, Bykov K, Choudhry NK, et al. Type of stress ulcer prophylaxis and risk of nosocomial pneumonia in cardiac surgical patients: cohort study. BMJ 2013; 347:f5416.
  32. Howell MD, Novak V, Grgurich P, et al. Iatrogenic gastric acid suppression and the risk of nosocomial Clostridium difficile infection. Arch Intern Med 2010; 170:784-790.
  33. Buendgens L, Bruensing J, Maths M, et al. Administration of proton pump inhibitors in critically ill medical patients is associated with increased risk of developing Clostridium difficile-associated diarrhea. J Crit Care. 2014 Aug; 29(4):696.e11-5.
  34. Eom CS, Jeon CY, Lim JW, et al. Use of acid-suppressive drugs on risk of pneumonia: a systematic review and meta-analysis. CMAJ. 2011; 183:310-319.
  35. Miano T, Reichert M, Houle T, et al. Nosocomial pneumonia risk and stress ulcer prophylaxis: a comparison of pantoprazole vs ranitidine in cardiothoracic surgery patients. Chest. 2009 Aug; 136(2):440-7.
  36. Qadeer MA, Richter JE, Brotman DJ. Hospital-acquired gastrointestinal bleeding outside the critical care unit: risk factors, role of acid suppression, and endoscopy findings. J Hosp Med. 2006; 1:13-20.
  37. Gupta R, Marshall J, Munoz JC, Kottoor R, Jamal MM, Vega KJ. Decreased acid suppression therapy overuse after education and medication reconciliation. International journal of clinical practice. 2013 Jan; 67(1):60-5.
  38. Zeitoun A, Zeineddine M, Dimassi H. Stress ulcer prophylaxis guidelines: Are they being implemented in Lebanese health care centers? World J Gastrointest Pharmacol Ther. 2011; 2(4):27-35. doi:10.4292/wjgpt.v2.i4.27
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