سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Sasan, Mohammad Saeed, AmelJamehdar, Saeid, Donyadideh, Nahid. (1401). Meningitis after MMR vaccination in Mashhad, Iran. , 10(6), 16205-16213. doi: 10.22038/ijp.2022.62275.4773
Mohammad Saeed Sasan; Saeid AmelJamehdar; Nahid Donyadideh. "Meningitis after MMR vaccination in Mashhad, Iran". , 10, 6, 1401, 16205-16213. doi: 10.22038/ijp.2022.62275.4773
Sasan, Mohammad Saeed, AmelJamehdar, Saeid, Donyadideh, Nahid. (1401). 'Meningitis after MMR vaccination in Mashhad, Iran', , 10(6), pp. 16205-16213. doi: 10.22038/ijp.2022.62275.4773
Sasan, Mohammad Saeed, AmelJamehdar, Saeid, Donyadideh, Nahid. Meningitis after MMR vaccination in Mashhad, Iran. , 1401; 10(6): 16205-16213. doi: 10.22038/ijp.2022.62275.4773

Meningitis after MMR vaccination in Mashhad, Iran

Journal of Pediatric Perspectives
مقاله 11، دوره 10، شماره 6، شهریور 2022، صفحه 16205-16213    اصل مقاله (425.96 K)
نوع مقاله: original article
شناسه دیجیتال (DOI): 10.22038/ijp.2022.62275.4773
نویسندگان
Mohammad Saeed Sasan* 1؛ Saeid AmelJamehdar2؛ Nahid Donyadideh3
1Department of Pediatrics. Faculty of Medicine. Mashhad University of Medical Sciences, Mashhad, Iran
2Assistant professor of virology,Faculty of medicine Mashhad university of medical science,Mashhsd Iran.
3Department of neurology, Mashhad University of Medical Sciences, Qhaem Hospital Mashhad, Iran
چکیده
Background: More than 20 years after the introduction of the mumps vaccine in the Iranian national vaccination program, there are concerns about meningitis induced by the Measles, Mumps, and Rubella (MMR) vaccine. The aim of this study is to virologically determine the incidence of MMR-induced meningitis in Mashhad, Iran.
Method: This is an observational prospective study during which all children who were admitted (in all hospitals of Mashhad) under the clinical suspicion of meningitis and had a history of MMR vaccination during the past 45 days were included. A polymerase chain reaction (PCR) test for mumps virus and enterovirus (EV) was done on cerebrospinal fluid (CSF) samples with pleocytosis.
Results: During 13 months of study, 55 children were hospitalized for suspicion of meningitis and had a history of recent MMR shots (94% presented with a febrile seizure). Meningitis was confirmed by CSF pleocytosis in 23 (2 bacterial and 21 aseptic) cases (44.2%). All incidents of meningitis had occurred after the first MMR. The incidence of any kind of aseptic meningitis, EV meningitis, and mumps meningitis during 45 days after the first MMR was, respectively, 19.9, 5.71, and 1.9 per 100,000 cases. The number of meningitis cases during the first 3 months after MMR was, respectively, 4.5 and 2 times more than the cases that occurred during the 3 months before and 3-6 months after MMR.
Conclusion: Around 40% of all cases of meningitis (between 4 and 43 months of age) occur during the first 3 months after the first MMR vaccination (12-15 months). The disproportionate increase of aseptic meningitis after the first MMR is strong epidemiologic evidence in favor of mumps vaccine induced meningitis.
کلیدواژه‌ها
Mumps؛ Meningitis؛ Febrile convulsion؛ Vaccine؛ Iran
مراجع
  1. Ghabouli Shahroodi MJ, Ghazvini K, Sadeghi R, Sasan MS. Enteroviral Meningitis in Neonates and Children of Mashhad, Iran. Jundishapur J Microbiol. 2016; 9(5):e19955-e.
  2. Sasan S, Abdolvahab A, Ziyaeyan M. Epidemiology of Aseptic Meningitis in Infants and Children (Shiraz - Iran). Archives of Clinical Infectious Diseases. 2012; 7:116-8.
  3. Jorquera L A, Ugarte C D, Avilés L C, Delpiano M L. Meningitis aséptica por virus parotídeo asociada a la vacuna. Revista chilena de infectología. 2020; 37:769-74.
  4. Sahra S, Jahangir A, Glaser A, Mobarakai N, Jahangir A. Case report: aseptic meningitis secondary to varicella-zoster virus (VZV) without an exanthem post MMR vaccination. BMC Infect Dis. 2021; 21(1):746-.
  5. Sugiura AY, A. Aseptic meningitis as a complication of mumps vaccination. Pediatr Infect Dis J. 1991; 10(3):5.
  6. Dorreh FaMH. Adverse events associated with MMR vaccines in Arak. Journal of Iranian clinical research. 2015; 1(1):4.
  7. 7. Esteghamati A KA, Heshmat R, Gouya MM, Salar Amoli M, Armin S, F M. Adverse reactions following immunization with MMR vaccine in children in selected provinces of Iran. Arch Iran Med. 2011; 14(2):5.
  8. Oskouie A BM, Malekian A. Relationship between Aseptic Meningitis and MMR Vaccination. Medical Journal of Tabriz University of Medical Sciences. 2007; 28(4):4.
  9. Sasan MS HSM. Aseptic meningitis after MMR vaccination in children of Mashhad. Medical journal of Mashhad University of medical sciences. 2010; 53(3):6.
  10. Pediatrics AAo. Pickering LK BC, Kimberlin DW, Long SS, eds, editor. Elk Grove Village, IL: American Academy of Pediatrics; 2012. 1 p.
  11. Nakayama T. Causal relationship between immunological responses and adverse reactions following vaccination. Vaccine. 2019; 37(2):366-71.
  12. Mamishi S, Sarkardeh M, Pourakbari B, Keshavarz Valian S, Sabouni F, Mahmoudi S. Aseptic meningitis after measles–mumps–rubella (MMR) vaccination. British Journal of Biomedical Science. 2016; 73(2):84-6.
  13. Sharma HJ, Oun SA, Bakr SS, Kapre SV, Jadhav SS, Dhere RM, Bhardwaj S. No demonstrable association between the Leningrad-Zagreb mumps vaccine strain and aseptic meningitis in a large clinical trial in Egypt. Clin Microbiol Infect. 2010; 16(4):347-52.
  14. Demicheli V, Rivetti A, Debalini MG, Di Pietrantonj C. Vaccines for measles, mumps and rubella in children. Cochrane Database Syst Rev. 2012; 2: CD004407.
  15. Fujinaga T, Motegi Y, Tamura H, Kuroume T. A prefecture-wide survey of mumps meningitis associated with measles, mumps and rubella vaccine. Pediatr Infect Dis J. 1991; 10(3):204-9.
  16. Jonville-Bera AP, Autret E, Galy-Eyraud C, Hessel L. Aseptic meningitis following mumps vaccine. A retrospective survey by the French Regional Pharmacovigilance centers and by Pasteur-Merieux Serums & Vaccines. Pharmacoepidemiol Drug Saf. 1996; 5(1):33-7.
  17. da Cunha SS, Rodrigues LC, Barreto ML, Dourado I. Outbreak of aseptic meningitis and mumps after mass vaccination with MMR vaccine using the Leningrad-Zagreb mumps strain. Vaccine. 2002; 20(7-8):1106-12.
  18. Makela A, Nuorti JP, Peltola H. Neurologic disorders after measles-mumps-rubella vaccination. Pediatrics. 2002; 110(5):957-63.
  19. Kermanian M, Soleimanjahi H, Arefian E, Bamdad T. Enrichment of cerebrospinal fluid samples on cell culture for enhancement of sensitivity of mumps and enterovirus detection by multiplex RT-PCR. Diagnostic Microbiology and Infectious Disease. 2008; 60(4):375-9.
  20. Krause CH, Eastick K, Ogilvie MM. Real-time PCR for mumps diagnosis on clinical specimens—Comparison with results of conventional methods of virus detection and nested PCR. Journal of Clinical Virology. 2006; 37(3):184-9.
  21. Batra N. Neurological Disorders Associated with Measles-Mumps-Rubella Vaccination- a Review Science Journal of Public Health. 2015; 3(1):6.
  22. Feenstra B, Pasternak B, Geller F, Carstensen L, Wang T, Huang F, Eitson JL, Hollegaard MV, Svanström H, Vestergaard M, Hougaard DM, Schoggins JW, Jan LY, Melbye M, Hviid A. Common variants associated with general and MMR vaccine-related febrile seizures. Nat Genet. 2014; 46(12):9.
  23. Vestergaard M, Hviid A, Madsen KM, Wohlfahrt J, Thorsen P, Schendel D, Melbye M, Olsen J. MMR vaccination and febrile seizures: evaluation of susceptible subgroups and long-term prognosis. JAMA. 2004; 292(3):351-7.
  24. Ward KN, Bryant NJ, Andrews NJ, Bowley JS, Ohrling A, Verity CM, Ross EM, Miller E. Risk of serious neurologic disease after immunization of young children in Britain and Ireland. Pediatrics. 2007; 120(2):314-21.
  25. Maglione MA, Das L, Raaen L, Smith A, Chari R, Newberry S, Shanman R, Perry T, Goetz MB, Gidengil C. Safety of vaccines used for routine immunization of U.S. children: a systematic review. Pediatrics. 2014; 134(2):325-37.
آمار
تعداد مشاهده مقاله: 926
تعداد دریافت فایل اصل مقاله: 603