Carvacrol attenuated neuroinflammation, oxidative stress and depression and anxiety like behaviors in lipopolysaccharide-challenged rats | ||
Avicenna Journal of Phytomedicine | ||
دوره 12، شماره 5، آذر و دی 2022، صفحه 514-526 اصل مقاله (833.05 K) | ||
نوع مقاله: Original Research Article | ||
شناسه دیجیتال (DOI): 10.22038/ajp.2022.20005 | ||
نویسندگان | ||
Hossein Salmani1؛ Zahra Hakimi2؛ Zohre Arab3؛ Narges Marefati4؛ Mohammad Reza Mahdinezhad5؛ Abolfazl RezaeiGolestan5؛ Farimah Beheshti6؛ Mohammad Soukhtanloo7؛ AmirAli Mahnia8؛ Mahmoud Hosseini* 8 | ||
1Student Research Committee, Jiroft University of Medical Sciences, Jiroft, Iran | ||
2Faculty of Medicine, Ghalib University, Herat, Afghanistan | ||
3Neuroscience Research Center, Mashhad University of Medical Sciences, Mashhad, Iran | ||
4Department of Physiology and Medical Physics, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran | ||
5Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran | ||
6Neuroscience Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran. | ||
7Department of Biochemistry, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran | ||
8Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran | ||
چکیده | ||
Objective: The beneficial effect of carvacrol on neuroinflammation, oxidative damage of brain tissue, and depressive- and anxiety-like behaviors after lipopolysaccharide (LPS) administration were evaluated in rats. Materials and Methods: Vehicle (1% Tween 80), 1 mg/kg of LPS, and carvacrol (25, 50, or 100 mg/kg administered prior to LPS) were injected and behavioral and biochemical tests were done. Results: The results of forced swim test revealed that carvacrol attenuated immobility time and increased activity and climbing times (p<0.05 to p<0.001). The results of elevated plus maze also revealed that treatment by carvacrol prolonged the open arms time and entries and decreased the time and entries in the closed arms (p<0.05 to p<0.01). Carvacrol enhanced crossing, time, and traveled distance in the central segment of the open field and increased total crossing and distance while attenuating the peripheral zone time (p<0.05 to p<0.001). All doses of carvacrol attenuated TNF- α (tumor necrosis factor α) and NO (nitric oxide) in the brain (p<0.01 to p<0.001). The 50 and the 100 mg/kg doses of carvacrol decreased malondialdehyde (p<0.001 for both), and the 100 mg/kg dose of carvacrol increased the content of the thiol (p<0.001). Conclusion: In conclusion, carvacrol improved the behavioral consequences of LPS challenge and attenuated neuroinflammation and brain tissue oxidative stress in rats. | ||
کلیدواژهها | ||
Inflammation؛ Anxiety؛ Depression؛ Carvacrol؛ Oxidative stress | ||
مراجع | ||
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