Comparison between viral vector and mRNA based COVID-19 vaccination in prevalence and severity of regional immune reactions, and 18F-FDG PET/CT features | ||
| Asia Oceania Journal of Nuclear Medicine and Biology | ||
| مقاله 2، دوره 11، شماره 1، فروردین 2023، صفحه 4-12 اصل مقاله (1.68 M) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22038/aojnmb.2022.63110.1443 | ||
| نویسندگان | ||
| Narjess Ayati* 1؛ Scott Evans1؛ Seyed Rasoul Zakavi2؛ Simon Gruenewald1 | ||
| 1Department of Nuclear Medicine, Ultrasound & PET, Westmead Hospital, NSW, Australia | ||
| 2Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| چکیده | ||
| Objective(s): The coronavirus pandemic caused by SARS-CoV-2 commenced in late 2019, and global wide vaccination appears to be the only reasonable solution to fight this dreadful virus. There are two main types of COVID-19 immunization using viral vector and mRNA-based vaccines. However, the impact of each of type on 18F-FDG PET/CT needs to be accurately assessed. This study aimed to compare the 18F-FDG PET/CT features of these two types of COVID-19 vaccines. Methods: A total of 188 patients referred for 18F-FDG PET/CT with a recent history of either BioNTech/Pfizer or AstraZeneca COVID-19 vaccination, and a control group of 40 patients with no history of any type of recent vaccination, were included in the study. 18F-FDG PET/CT studies of vaccinated patients assessed for injection site uptake and regional nodal and systemic reactions post vaccination. The data were compared to the control group and to the contralateral side for each patient. The findings were compared between patients who received Pfizer and AstraZeneca vaccines. Results: 18F-FDG PET/CT was semiquantitatively positive in 50.5% of the studied population for vaccine-related features. The ipsilateral axillary and infra- and supraclavicular lymph nodes were significantly larger in size and exhibited higher metabolic activity compared to the contralateral lymph nodes after both types of vaccination. The prevalence of regional nodal reactions post Pfizer and AstraZeneca vaccination was 39% and 17.9% on visual, and 61% and 47.6% on semiquantitative assessments, respectively. Patients receiving the Pfizer vaccine exhibited higher metabolic activity in the ipsilateral regional lymph nodes (p<0.05). No significant difference in the intensity of regional nodal reaction post vaccination was noted between the first four weeks. Conclusion: Significant local and regional nodal reactions are observed after both viral vector and mRNA COVID-19 vaccination with a tendency to extend toward the infra- and supraclavicular nodal stations but not to the pulmonary hilum. The greater intensity and extension of the nodal reaction after Pfizer vaccination suggests a higher possibility of false-positive results on 18F-FDG PET/CT studies using mRNA vaccination technology. | ||
| کلیدواژهها | ||
| BioNTech/Pfizer؛ COVID-19؛ Vaccination؛ 18F-FDG PET/CT؛ mRNA vaccine | ||
| مراجع | ||
|
1. WHO Coronavirus (COVID-19) Dashboard: World Health Organization; 2021. https:// covid19.who.int. Accessed September 18, 2021.
2. Santos-Filho OA. Identification of potential inhibitors of severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) main protease from non-natural and natural sources: a molecular docking study. J Braz Chem Soc. 2020; 31:2638–2643.
3. Ashish K, Nelin V, Raaijmakers H, Kim HJ, Singh C, Målqvist M. Increased immunization coverage addresses the equity gap in Nepal. Bull World Health Organ. 2017; 95:261–269.
4. Wolff JA, Malone RW, Williams P, et al. Direct gene transfer into mouse muscle in vivo. Science. 1990; 247:1465–8.
5. Karikó K, Muramatsu H, Welsh FA, et al. Incorporation of pseudouridine into mRNA yields superior nonimmunogenic vector with increased translational capacity and biological stability. Mol Ther. 2008; 16: 1833–1840.
6. Thess A, Grund S, Mui BL, et al. Sequence-engineered mRNA without chemical nucleoside modifications enables an effective protein therapy in large animals. Mol Ther. 2015; 23:1456–1464.
7. Karikó K, Muramatsu H, Ludwig J, Weissman D. Generating the optimal mRNA for therapy: HPLC purification eliminates immune activation and improves trans-lation of nucleoside-modified, protein -encoding mRNA. Nucleic Acids Res. 2011; 39:e142.
8. Pardi N, Hogan MJ, Porter FW, Weissman D. mRNA vaccines - a new era in vaccinology. Nat Rev Drug Discov. 2018; 17:261–279.
9. Doerfler W. Adenoviral vector DNA- and SARS-CoV-2 mRNA-Based COVID-19 vaccines: possible integration into the human genome - Are adenoviral genes expressed in vector-based vaccines? Virus Res. 2021; 302:198466.
10. Ayati N, Jesudason S, Berlangieri SU, Scott AM. Generalized lymph node activation after influenza vaccination on 18F FDG-PET/CT imaging, an important pitfall in PET interpretation. Asia Ocean J Nucl Med Biol. 2017; 5:148–150.
11. Ligtenberg AJM, Brand HS. What are the differences between the various COVID-19 vaccines? Ned Tijdschr Tandheelkd. 2021; 128 [Epub ahead of print].
12. Minamimoto R, Kiyomatsu T. Effects of COVID-19 vaccination on FDG-PET/CT imaging: a literature review. Glob Health Med. 2021; 3:129–133.
13. McIntosh LJ, Bankier AA, Vijayaraghavan GR, Licho R, Rosen MP. COVID-19 vaccination-related uptake on FDG PET/CT: an emerging dilemma and suggestions for management. AJR Am J Roentgenol. 2021 [Epub ahead of print].
14. Treglia G, Cuzzocrea M, Giovanella L, Elzi L, Muoio B. Prevalence and significance of hypermetabolic lymph nodes detected by 2-[18F] FDG PET/CT after COVID-19 vaccination: a systematic review and a meta-analysis. Pharmaceuticals (Basel). 2021; 14:E762.
15. Cohen D, Krauthammer SH, Cohen YC, et al. Correlation between BNT162b2 mRNA COVID-19 vaccine-associated hyper-metabolic lymphadenopathy and humoral immunity in patients with hematologic malignancy. Eur J Nucl Med Mol Imaging. 2021; 48:3540–3549.
16. Eshet Y, Tau N, Alhoubani Y, Kanana N, Domachevsky L, Eifer M. Prevalence of increased FDG PET/CT axillary lymph node uptake beyond 6 weeks after mRNA COVID-19 vaccination. Radiology. 2021; 300: E345–E347.
17. Sadarangani M, Marchant A, Kollmann TR. Immunological mechanisms of vaccine-induced protection against COVID-19 in humans. Nat Rev Immunol. 2021; 21:475–484.
| ||
|
آمار تعداد مشاهده مقاله: 1,144 تعداد دریافت فایل اصل مقاله: 574 |
||