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Mohamed, Montaser, Mahmoud, Ramadan, Sayed, Sherif, Abdel-Gawad, Abdelhady, Hanna, Christina, Fahmy, Eman. (1401). The Role of Serum Periostin Level in Different Pediatric Allergic Diseases: A Case-Control Study. , 10(5), 15937-15944. doi: 10.22038/ijp.2022.63426.4838
Montaser M. Mohamed; Ramadan A Mahmoud; Sherif A. Sayed; Abdelhady R. Abdel-Gawad; Christina K. Hanna; Eman M. Fahmy. "The Role of Serum Periostin Level in Different Pediatric Allergic Diseases: A Case-Control Study". , 10, 5, 1401, 15937-15944. doi: 10.22038/ijp.2022.63426.4838
Mohamed, Montaser, Mahmoud, Ramadan, Sayed, Sherif, Abdel-Gawad, Abdelhady, Hanna, Christina, Fahmy, Eman. (1401). 'The Role of Serum Periostin Level in Different Pediatric Allergic Diseases: A Case-Control Study', , 10(5), pp. 15937-15944. doi: 10.22038/ijp.2022.63426.4838
Mohamed, Montaser, Mahmoud, Ramadan, Sayed, Sherif, Abdel-Gawad, Abdelhady, Hanna, Christina, Fahmy, Eman. The Role of Serum Periostin Level in Different Pediatric Allergic Diseases: A Case-Control Study. , 1401; 10(5): 15937-15944. doi: 10.22038/ijp.2022.63426.4838

The Role of Serum Periostin Level in Different Pediatric Allergic Diseases: A Case-Control Study

International Journal of Pediatrics
دوره 10، شماره 5، مرداد 2022، صفحه 15937-15944    اصل مقاله (581.61 K)
نوع مقاله: original article
شناسه دیجیتال (DOI): 10.22038/ijp.2022.63426.4838
نویسندگان
Montaser M. Mohamed1؛ Ramadan A Mahmoud* 2؛ Sherif A. Sayed3؛ Abdelhady R. Abdel-Gawad4؛ Christina K. Hanna5؛ Eman M. Fahmy6
1Pediatrics Department, Faculty of Medicine, Sohag University, Sohag, Egypt
2department of pediatrics, sohag Faculty of medicine, Sohag University, Egypt
3Department of Clinical and chmical pathology, Sohag faculty of medicine Sohag University, Egypt
4Department of clinical and chemical Pathology, Sohag faculty of medicine, Sohag university, Egypt.
5Department of Pediatrics, Faculty of Medicine, Sohag University, Sohag, Egypt.
6Pediatrics department Sohag faculty of medicine Sohag university, Egypt
چکیده
Background: Allergic diseases represent one of the most common types of diseases globally and affect a large sector of population especially children. The main purpose of this study is to evaluate the relation between serum periostin and different allergic diseases and to compare them with children of non-allergic diseases as a control group.
Methods: 80 children were included in the study; 40 had allergic diseases and 40 children had no allergic diseases as controls. All participants completed the history and clinical examination, complete blood count, total serum immunoglobulin IgE (UI/ml), and serum periostin level.
Results: Among the patients with allergic diseases, bronchial asthma was the most common diagnosed disease 29/40 (72.50%). Patients with allergic diseases had significantly higher mean (±SD) serum periostin when compared to infants with no allergic diseases (271.9±263.27 ng/ml and 115.33±191.42 ng/ml, P-value 0.0001). However, highly elevated serum periostin >150 ng/ml were found exclusively in patients with allergic diseases 22/40 (55.00%) and only in 4/40 (10.0%) of the controls (p-value<0.0001). Furthermore, there were a statistically significant difference between the patients with different degrees of allergic diseases severity and serum periostin level as it was 1080±251.73 ng/ml in severe allergic diseases compared to 244.5±263.57 ng/ml in mild allergic diseases (P- value 0.01).
Conclusion: The most common type of allergic diseases in our study was bronchial asthma. Higher serum periostin levels were observed in allergic patients in comparison to the controls; and they were found to have a significant relationship with disease severity.
کلیدواژه‌ها
Allergic diseases؛ Serum periostin؛ Serum immunoglobulin E؛ Bronchial asthma
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