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Lahimgarzadeh, Roya, Vaseghi, Salar, Nasehi, Mohammad, Rouhollah, Fatemeh. (1400). Effect of multi-epitope derived from HIV-1 on REM sleep deprivation-induced spatial memory impairment with respect to the level of immune factors in mice. , 25(2), 164-172. doi: 10.22038/ijbms.2022.61175.13536
Roya Lahimgarzadeh; Salar Vaseghi; Mohammad Nasehi; Fatemeh Rouhollah. "Effect of multi-epitope derived from HIV-1 on REM sleep deprivation-induced spatial memory impairment with respect to the level of immune factors in mice". , 25, 2, 1400, 164-172. doi: 10.22038/ijbms.2022.61175.13536
Lahimgarzadeh, Roya, Vaseghi, Salar, Nasehi, Mohammad, Rouhollah, Fatemeh. (1400). 'Effect of multi-epitope derived from HIV-1 on REM sleep deprivation-induced spatial memory impairment with respect to the level of immune factors in mice', , 25(2), pp. 164-172. doi: 10.22038/ijbms.2022.61175.13536
Lahimgarzadeh, Roya, Vaseghi, Salar, Nasehi, Mohammad, Rouhollah, Fatemeh. Effect of multi-epitope derived from HIV-1 on REM sleep deprivation-induced spatial memory impairment with respect to the level of immune factors in mice. , 1400; 25(2): 164-172. doi: 10.22038/ijbms.2022.61175.13536

Effect of multi-epitope derived from HIV-1 on REM sleep deprivation-induced spatial memory impairment with respect to the level of immune factors in mice

Iranian Journal of Basic Medical Sciences
مقاله 4، دوره 25، شماره 2، اردیبهشت 2022، صفحه 164-172    اصل مقاله (1.25 M)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2022.61175.13536
نویسندگان
Roya Lahimgarzadeh1؛ Salar Vaseghi2؛ Mohammad Nasehi3، 4؛ Fatemeh Rouhollah* 5
1Department of Cellular and Molecular Biology, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
2Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
3Department of Cognitive Neuroscience, Institute for Cognitive Science Studies (ICSS), Tehran, Iran
4Cognitive and Neuroscience Research Center (CNRC), Amir-Almomenin Hospital, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
5Department of Cellular and Molecular Biology, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
چکیده
Objective(s): Sleep deprivation (SD) has a negative impact on cognitive functions including learning and memory. Many studies have shown that rapid-eye-movement (REM) SD also disrupts memory performance. In this study, we aimed to investigate the effect of multi-epitope Gag-Pol-Env-Tat derived from Human immunodeficiency virus 1 (HIV-1) on REM SD-induced spatial memory impairment with respect to the levels of interleukin-4 (IL-4), interleukin-17 (IL-17), interferon-gamma (IFN-γ), immunoglobulin G1 (IgG1), immunoglobulin G2a (IgG2a), and lymphocyte proliferation in NMRI mice. We used multi-epitope Gag-Pol-Env-Tat derived from HIV-1 because Gag-Pol-Env-Tat immunogen sequence is one of the most sensitive immunogen sequences of HIV-1 that can significantly augment cellular and humoral immune systems, leading to the improvement of cognitive functions. 
Materials and Methods: Morris water maze apparatus was used to assess spatial memory, and multi-platform apparatus was used to induce RSD for 24 hr. Multi-epitope derived from HIV-1 was subcutaneously injected at the dose of 20 µgr/ml, once and fourteen days before RSD. 
Results: RSD impaired spatial memory and injection of multi-epitope derived from HIV-1 reversed this effect. RSD decreased IL-4, IgG1, and IgG2a levels, while multi-epitope derived from HIV-1 reversed these effects. Multi-epitope derived from HIV-1 also increased lymphocyte proliferation and decreased IL-17 levels in both control and RSD mice. 
Conclusion: Multi-epitope derived from HIV-1 may improve memory performance via induction of anti-inflammatory immune response. 
کلیدواژه‌ها
Epitopes؛ HIV-1؛ Immunologic factors؛ Sleep deprivation؛ Spatial memory
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