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Patel, Ganeshkumar, MANDAL, ABHIJIT, Mishra, Ritusha, Choudhary, Sunil, Mishra, Himanshu. (1401). Role of Overall Treatment Time When Estimating TCP & NTCP of Head & Neck Radiotherapy Treatment Plans in Altered Fractionation. , 20(2), 106-113. doi: 10.22038/ijmp.2022.60625.2020
Ganeshkumar Ramesh Patel; ABHIJIT MANDAL; Ritusha Mishra; Sunil Choudhary; Himanshu Mishra. "Role of Overall Treatment Time When Estimating TCP & NTCP of Head & Neck Radiotherapy Treatment Plans in Altered Fractionation". , 20, 2, 1401, 106-113. doi: 10.22038/ijmp.2022.60625.2020
Patel, Ganeshkumar, MANDAL, ABHIJIT, Mishra, Ritusha, Choudhary, Sunil, Mishra, Himanshu. (1401). 'Role of Overall Treatment Time When Estimating TCP & NTCP of Head & Neck Radiotherapy Treatment Plans in Altered Fractionation', , 20(2), pp. 106-113. doi: 10.22038/ijmp.2022.60625.2020
Patel, Ganeshkumar, MANDAL, ABHIJIT, Mishra, Ritusha, Choudhary, Sunil, Mishra, Himanshu. Role of Overall Treatment Time When Estimating TCP & NTCP of Head & Neck Radiotherapy Treatment Plans in Altered Fractionation. , 1401; 20(2): 106-113. doi: 10.22038/ijmp.2022.60625.2020

Role of Overall Treatment Time When Estimating TCP & NTCP of Head & Neck Radiotherapy Treatment Plans in Altered Fractionation

Iranian Journal of Medical Physics
مقاله 8، دوره 20، شماره 2، خرداد و تیر 2023، صفحه 106-113    اصل مقاله (1.35 M)
نوع مقاله: Original Paper
شناسه دیجیتال (DOI): 10.22038/ijmp.2022.60625.2020
نویسندگان
Ganeshkumar Ramesh Patel1؛ ABHIJIT MANDAL* 2؛ Ritusha Mishra3؛ Sunil Choudhary4؛ Himanshu Mishra4
1RTRM Department, Institute of Medical Sciences, Banaras Hindu University, Varanasi-221005, INDIA
2BANARAS HINDU UNIVERSITY
3RTRM Department, Institute of Medical Sciences, BHU, Varanasi-221005
4Department of Radiotherapy and Radiation Medicine Institute of Medical Sciences Banaras Hindu University VARANASI, Uttar Pradesh, INDIA.
چکیده
Introduction: The present study demonstrated role of overall treatment time when estimating tumor control probability (TCP) and normal tissue complication probability (NTCP) for moderately hypofractionated and accelerated fractionation schedules in head & neck treatment plans. Repopulation effect in the squamous cell carcinoma is an influencing factor that should be considered when evaluating TCP and NTCP in early responding tissue. This effect can be incorporated by the means of overall treatment time in days.
Material and Methods: The proposed study separated in two parts. In the first case, we assumed four moderately hypofractionated schedules for demonstration, including conventional fractionation schedule (CFS) (70Gy/35 #), fractionation schedule 1 (66Gy/30#), fractionation schedule 2 (60Gy/24#) & fractionation schedule 3 (55Gy/20#). Four independent volumetric modulated arc treatment plans were generated at different fractionation schedules for 15 patient’s data set and therefore led to a total of 60 treatment plans. The treatment plan created for CFS is the reference plan for comparison of calculated TCP & NTCP amongst the four plans. The rest three plans for each patient were created simply by changing the dose prescription for FS1, FS2 & FS3, the mean total dose and dose per fraction. In the second scenario, conventional fractionation schedule (66Gy/33# with five fractions per week) compared against accelerated fractionation schedule (66Gy/33# with six fractions per week). The cumulative dose volume histogram for all treatment plans were used for TCP/NTCP estimation by Niemierko EUD, Poisson model and LKB model. The TCP/NTCP calculated in two different way for tumor & oral mucosa of head & neck site. Contrary to the second case, the overall treatment time (OTT) in days not accounted in the first case.
Results: It was statistically significant difference (p<0.05) obtained between calculated TCP/NTCP in both moderately hypofractionated and accelerated fractionation schedules.
Conclusion: There is significant impact of OTT and it should be considered when evaluating TCP/NTCP for early responding tissue.
کلیدواژه‌ها
Overall Treatment Time؛ Tumor Control Probability؛ Normal Tissue Complication Probability؛ Accelerated Fractionation؛ Moderately Hypofractionation
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