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G R, Varshitha, Sakalecha, Anil, A V, Darshan, A, Chaithanya. (1401). Role of Diffusion Weighted Imaging with Corresponding Apparent Diffusion Coefficient Values in Differentiating Benign and Malignant Breast Lesions. , 19(6), 383-389. doi: 10.22038/ijmp.2022.60639.2026
Varshitha G R; Anil Kumar Sakalecha; Darshan A V; Chaithanya A. "Role of Diffusion Weighted Imaging with Corresponding Apparent Diffusion Coefficient Values in Differentiating Benign and Malignant Breast Lesions". , 19, 6, 1401, 383-389. doi: 10.22038/ijmp.2022.60639.2026
G R, Varshitha, Sakalecha, Anil, A V, Darshan, A, Chaithanya. (1401). 'Role of Diffusion Weighted Imaging with Corresponding Apparent Diffusion Coefficient Values in Differentiating Benign and Malignant Breast Lesions', , 19(6), pp. 383-389. doi: 10.22038/ijmp.2022.60639.2026
G R, Varshitha, Sakalecha, Anil, A V, Darshan, A, Chaithanya. Role of Diffusion Weighted Imaging with Corresponding Apparent Diffusion Coefficient Values in Differentiating Benign and Malignant Breast Lesions. , 1401; 19(6): 383-389. doi: 10.22038/ijmp.2022.60639.2026

Role of Diffusion Weighted Imaging with Corresponding Apparent Diffusion Coefficient Values in Differentiating Benign and Malignant Breast Lesions

Iranian Journal of Medical Physics
مقاله 26، دوره 19، شماره 6، بهمن و اسفند 2022، صفحه 383-389    اصل مقاله (1.16 M)
نوع مقاله: Original Paper
شناسه دیجیتال (DOI): 10.22038/ijmp.2022.60639.2026
نویسندگان
Varshitha G R؛ Anil Kumar Sakalecha* ؛ Darshan A V؛ Chaithanya A
Department of Radiodiagnosis, Sri Devaraj Urs Medical College, SDUAHER, Tamaka, Kolar, Karnataka, India.
چکیده
Introduction: The objective of this study is to assess the role of diffusion weighted (DW) magnetic resonance imaging (MRI) along with its corresponding apparent diffusion coefficient (ADC) values in differentiating malignant from benign breast lesions.
Material and Methods: Patients with breast lesions and those who met inclusion and exclusion criteria were included in this study. MR Mammography (MRM) was performed on 1.5 Tesla MR Scanner (Siemens® Magnetom Avanto®). DWI was performed at b-values of 50, 400 and 800 s/mm2 followed by ADC sequence.
Results: 50 patients with a total of 81 breast lesions and whose diagnosis was histopathologically confirmed following MRM were included in the study. We observed that benign lesions showed no restricted diffusion with an ADC value of >1.3 x 10-3 mm2/s. Most of the malignant lesions showed restricted diffusion with ADC value of < 1.3 10-3 mm2/s. A non-malignant condition, Benign Phyllodes tumor (n=1) showed no restricted diffusion but had a low ADC of 1.1 x 10-3 giving false positive result. Mucinous carcinomas (n=5) showed no restricted diffusion and had a mean ADC value of >1.3 x 10-3. We observed sensitivity of DWI along with ADC value to be 86.8% and specificity as 97.6%.
Conclusion: DW-MRI can be employed as a fast unenhanced screening modality for breast cancer with high sensitivity. Considering ADC values along with DW-MRI increased its detection rates and hence both can be incorporated as supplementary techniques in multiparametric MRM.
کلیدواژه‌ها
Breast Cancer Magnetic Resonance Imaging Mammography Diffusion؛ Magnetic Resonance Imaging Apparent Diffusion Coefficient
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