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Askarian-Amiri, Shaghayegh, Fotovat eskandari, Hoda, Ramezani, Fatemeh, Vahabzadeh, Gelare, Aboutaleb, Nahid. (1400). Lavender protects H9c2 cardiomyocytes against oxygen-glucose deprivation (OGD)-induced injury via targeting the JAK2/STAT3 pathway. , 25(2), 263-267. doi: 10.22038/ijbms.2022.54751.12280
Shaghayegh Askarian-Amiri; Hoda Fotovat eskandari; Fatemeh Ramezani; Gelare Vahabzadeh; Nahid Aboutaleb. "Lavender protects H9c2 cardiomyocytes against oxygen-glucose deprivation (OGD)-induced injury via targeting the JAK2/STAT3 pathway". , 25, 2, 1400, 263-267. doi: 10.22038/ijbms.2022.54751.12280
Askarian-Amiri, Shaghayegh, Fotovat eskandari, Hoda, Ramezani, Fatemeh, Vahabzadeh, Gelare, Aboutaleb, Nahid. (1400). 'Lavender protects H9c2 cardiomyocytes against oxygen-glucose deprivation (OGD)-induced injury via targeting the JAK2/STAT3 pathway', , 25(2), pp. 263-267. doi: 10.22038/ijbms.2022.54751.12280
Askarian-Amiri, Shaghayegh, Fotovat eskandari, Hoda, Ramezani, Fatemeh, Vahabzadeh, Gelare, Aboutaleb, Nahid. Lavender protects H9c2 cardiomyocytes against oxygen-glucose deprivation (OGD)-induced injury via targeting the JAK2/STAT3 pathway. , 1400; 25(2): 263-267. doi: 10.22038/ijbms.2022.54751.12280

Lavender protects H9c2 cardiomyocytes against oxygen-glucose deprivation (OGD)-induced injury via targeting the JAK2/STAT3 pathway

Iranian Journal of Basic Medical Sciences
مقاله 17، دوره 25، شماره 2، اردیبهشت 2022، صفحه 263-267    اصل مقاله (391.61 K)
نوع مقاله: Short Communication
شناسه دیجیتال (DOI): 10.22038/ijbms.2022.54751.12280
نویسندگان
Shaghayegh Askarian-Amiri1؛ Hoda Fotovat eskandari2؛ Fatemeh Ramezani2؛ Gelare Vahabzadeh3؛ Nahid Aboutaleb* 2، 4
1Institut de Biologie Structurale (IBS), Univ. Grenoble Alpes, CEA, CNRS, 71 Avenue des Martyrs, 38000 Grenoble, France
2Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran
3Department of Pharmacology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
4Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
چکیده
Objective(s): This study was conducted to examine the therapeutic effects of lavender oil (LO) against oxygen-glucose deprivation (OGD)-induced injury in vitro model.
Materials and Methods: In this study, the OGD model was induced in the H9C2 cell line, and then the cells were treated with LO (10, 100, 1000, and 10000 μg/ml). The anti-inflammatory activity of LO (Jak2/Stat3) was evaluated by immunocytochemical assay. Likewise, the p-ERK/ERK level was measured by western blotting.
Results: Compared with only the OGD-induced injury model, cell survival increased after treatment with LO. Our results showed that 100 μg/ml of LO significantly decreased the expression of Jak2/Stat3 and the apoptotic activity 72 hr after reperfusion compared with the control group. Likewise, significant increases were observed in p-ERK/ERK in LO-treated groups. 
Conclusion: Collectively, these findings confirm that LO can be a good candidate to reduce OGD-induced injury in the H9C2 cell line through targeting Jak2/Stat3 and ERK pathways.
کلیدواژه‌ها
H9C2 cells؛ Inflammation؛ Ischemia/Reperfusion injury؛ Jak2 / Stat3؛ Lavender oil؛ p-ERK / ERK
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