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Boskabadi, Abbas, Mamouri, Gholamali, Boskabadi, Hassan, Pouralizadeh, Nasim, Moradi, Ali, Mehrad-Majd, Hassan. (1400). Clinical Significance of OATP2 Gene Variants in Iranian Neonates with Hyperbilirubinemia. , 13(1), 30-35. doi: 10.22038/ijn.2021.57052.2074
Abbas Boskabadi; Gholamali Mamouri; Hassan Boskabadi; Nasim Pouralizadeh; Ali Moradi; Hassan Mehrad-Majd. "Clinical Significance of OATP2 Gene Variants in Iranian Neonates with Hyperbilirubinemia". , 13, 1, 1400, 30-35. doi: 10.22038/ijn.2021.57052.2074
Boskabadi, Abbas, Mamouri, Gholamali, Boskabadi, Hassan, Pouralizadeh, Nasim, Moradi, Ali, Mehrad-Majd, Hassan. (1400). 'Clinical Significance of OATP2 Gene Variants in Iranian Neonates with Hyperbilirubinemia', , 13(1), pp. 30-35. doi: 10.22038/ijn.2021.57052.2074
Boskabadi, Abbas, Mamouri, Gholamali, Boskabadi, Hassan, Pouralizadeh, Nasim, Moradi, Ali, Mehrad-Majd, Hassan. Clinical Significance of OATP2 Gene Variants in Iranian Neonates with Hyperbilirubinemia. , 1400; 13(1): 30-35. doi: 10.22038/ijn.2021.57052.2074

Clinical Significance of OATP2 Gene Variants in Iranian Neonates with Hyperbilirubinemia

Iranian Journal of Neonatology
دوره 13، شماره 1، فروردین 2022، صفحه 30-35    اصل مقاله (801.26 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijn.2021.57052.2074
نویسندگان
Abbas Boskabadi1؛ Gholamali Mamouri1؛ Hassan Boskabadi1؛ Nasim Pouralizadeh2؛ Ali Moradi3؛ Hassan Mehrad-Majd* 4
1Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2Department of Pediatrics, Faculty of Medicine, Neyshabur University of Medical Sciences, Neyshabur, Iran
3Orthopedic Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
4Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده
Background: Neonatal hyperbilirubinemia is a life-threatening and multifactorial disorder affecting about 60%-80% of newborns during their first week of life. Various environmental and genetic factors can contribute to the occurrence of this problem. The present study aimed to investigate the relationship between the two organic anion transporter 2 (OATP2) gene polymorphisms (388A>G and 521T>C) and the risk of neonatal hyperbilirubinemia.
Methods: A total of 200 neonates, including 100 infants with pathological icterus without a specific cause as the case group and 100 healthy neonates as the control group, were included in this cross-sectional study. Using fresh blood DNA, allelic frequency and genotypic distribution of each variant were determined by polymerase chain reaction-restriction fragment length polymorphism method. The biochemical measurements were also performed for both groups.
Results: The two groups were similar in terms of gender, birth weight, gestational age, diet, and type of feeding. Allelic frequency and genotype distribution of the 388A>G and 521T>C polymorphisms did not show any significant association with hyperbilirubinemia both in crude and modified conditions (P>0.05). Moreover, no significant difference was observed between cases and controls in diplotypes and haplotypes analysis (P>0.05).
Conclusion: As evidenced by the obtained results, the neonates with hyperbilirubinemia were not different from healthy newborns in allelic frequency and genotypic distribution of the two variants of the OATP2 gene. It seems that these two polymorphisms are not correlated with the risk of hyperbilirubinemia in an Iranian neonatal population. Further studies with larger sample sizes are needed to confirm the results of this study.
 
 
کلیدواژه‌ها
Neonatal hyperbilirubinemia؛ OATP2 gene؛ Polymorphism؛ 388A>G؛ 521T>C
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