Antimicrobial Agents in Malignant Otitis Externa: A Systematic Review | ||
| Reviews in Clinical Medicine | ||
| دوره 8، شماره 4، اسفند 2021، صفحه 145-159 اصل مقاله (694.43 K) | ||
| نوع مقاله: Systematic review | ||
| شناسه دیجیتال (DOI): 10.22038/rcm.2021.60083.1374 | ||
| نویسنده | ||
| Mohamad Reza Afzalzadeh* | ||
| Sinus and Surgical Endoscopic Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. | ||
| چکیده | ||
| This systematic review determined the main antimicrobial agents resulting in MOE and spectrum antimicrobial therapy covering drug resistance in the disease. All the articles published in three electronic databases, including PubMed, Web of Science, and MEDLINE, were searched within November 15 to December 15, 2020. Eventually, 27 reports were identified assessing the clinical outcomes of patients with MOE. Generally, the mean age of patients with MOE in different studies was within the range of 59–82 years, and the male/female ratio was 1.8:1. The frequency of diabetes among patients with MOE was within the range of 40%-100%, and the frequency of facial nerve involvement was up to 60.7% in various studies. Pseudomonas aeruginosa is the most commonly reported causative organism in MOE. Methicillin-resistant Staphylococcus aureus is another organism leading to MOE. The main concerning issue in antibiotic therapy is the increasing isolation of bacterial strains resistant to this therapeutic approach. Generally, patients undergoing initial combination therapy have better outcomes compared to those receiving single therapy. Furthermore, the risk of ciprofloxacin resistance increased, especially when used as a monotherapy agent. The early diagnosis and treatment of patients with MOE are very crucial. In this regard, it is necessary to consider the management of diabetes for controlling the infection with antibiotics and debridement of necrotic tissue. Aggressive surgical management is suggested in some patients with MOE. | ||
| کلیدواژهها | ||
| Diabetes, Facial Nerve Involvement؛ Malignant External Otitis؛ Pseudomonas aeruginosa | ||
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