The neuropsychotropic effects of Crocus sativus L. (saffron): an overview of systematic reviews and meta-analyses investigating its clinical efficacy in psychiatric and neurological disorders | ||
| Avicenna Journal of Phytomedicine | ||
| دوره 12، شماره 5، آذر و دی 2022، صفحه 475-488 اصل مقاله (613.22 K) | ||
| نوع مقاله: Review Article | ||
| شناسه دیجیتال (DOI): 10.22038/ajp.2021.19300 | ||
| نویسندگان | ||
| Ahmad Shamabadi1؛ Alireza Hasanzadeh1؛ Shahin Akhondzadeh* 2 | ||
| 1School of Medicine, Tehran University of Medical Sciences, Tehran, Iran | ||
| 2Psychiatric Research Center, Roozbeh Psychiatric Hospital, Tehran University of Medical Sciences, Tehran, Iran | ||
| چکیده | ||
| Objective: Saffron is a spice derived from the Crocus sativus L. with antioxidant, anti-inflammatory, and neuroprotective effects. This study aims to systematically review the systematic reviews (SRs) investigating the clinical neuropsychotropic effects of saffron. Materials and Methods: The protocol of this SR was registered in PROSPERO (CRD42021268446). Scopus, ISI Web of Science, Embase, MEDLINE, PubMed, CINAHL, Cochrane Library, Google Scholar, and PROSPERO were searched up to June 6, 2021, to find SRs investigating the neuropsychotropic effects of saffron. The primary outcome was a report on whether or not saffron was effective in each study. AMSTAR was checked for the included reviews. Results: Twenty-three studies were reviewed with a mean AMSTAR score of 6.08 (ranging from 1 to 10). Thirteen SRs investigated the effects of saffron on depression. Six of the SRs studied its impact on sexual dysfunction. Each of the anxiety and cognitive disorders was discussed in three distinct reviews. Furthermore, possible effects of saffron on some other disorders, like premenstrual syndrome, postpartum depression, sleep disorders, and snacking behavior, have been reported. Conclusion: Saffron is beneficial, safe, and tolerable in treating the mentioned neurological and psychiatric disorders. Further high-quality, large-scale studies are recommended to rectify the shortcomings. | ||
| کلیدواژهها | ||
| Crocus sativus؛ Herbal medicine؛ Neurology؛ Pharmacognosy؛ Systematic review | ||
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| مراجع | ||
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Avgerinos KI, Vrysis C, Chaitidis N, Kolotsiou K, Myserlis PG, Kapogiannis D. 2020. Effects of saffron (Crocus sativus L.) on cognitive function. A systematic review of RCTs. Neurol Sci, 41: 2747-2754. Ayati Z, Yang G, Ayati MH, Emami SA, Chang D. 2020. Saffron for mild cognitive impairment and dementia: a systematic review and meta-analysis of randomised clinical trials. BMC Complement Med Ther, 20: 333. Borrelli F, Colalto C, Delfino DV, Iriti M, Izzo AA. 2018. Herbal dietary supplements for erectile dysfunction: a systematic review and meta-analysis. Drugs, 78: 643-673. Dai L, Chen L, Wang W. 2020. Safety and efficacy of saffron (Crocus sativus L.) for treating mild to moderate depression: a systematic review and meta-analysis. J Nerv Ment Dis, 208: 269-276. Davis SA, Feldman SR, Taylor SL. 2014. Use of St. John's wort in potentially dangerous combinations. J Altern Complement Med, 20: 578-579. Dwyer AV, Whitten DL, Hawrelak JA. 2011. Herbal medicines, other than St. John's Wort, in the treatment of depression: a systematic review. Altern Med Rev, 16: 40-49. Eder J, Herrling PL. 2016. Trends in modern drug discovery. Handb Exp Pharmacol, 232: 3-22. Ghaderi A, Asbaghi O, Reiner Ž, Kolahdooz F, Amirani E, Mirzaei H, Banafshe HR, Maleki Dana P, Asemi Z. 2020. The effects of saffron (Crocus sativus L.) on mental health parameters and C-reactive protein: A meta-analysis of randomized clinical trials. Complement Ther Med, 48: 102250. Hausenblas HA, Heekin K, Mutchie HL, Anton S. 2015. A systematic review of randomized controlled trials examining the effectiveness of saffron (Crocus sativus L.) on psychological and behavioral outcomes. J Integr Med, 13: 231-240. Hausenblas HA, Saha D, Dubyak PJ, Anton SD. 2013. Saffron (Crocus sativus L.) and Neuropsychotropic effects of saffron AJP, Vol. 12, No. 5, Sep-Oct 2022 487 major depressive disorder: a metaanalysis of randomized clinical trials. J Integr Med, 11: 377-383. Kahkeshani N, Hadjiakhoondi A, Khanavi M, Differentiation of Lavandula angustifolia Mill. and Nepeta menthoides Boiss & Buhse using microscopic and phytochemical evaluations, 14, 15 May 2014, 3rd National Congress on Medicinal Plants, Mashhad, Iran. Khaksarian M, Behzadifar M, Behzadifar M, Alipour M, Jahanpanah F, Re TS, Firenzuoli F, Zerbetto R, Bragazzi NL. 2019. The efficacy of Crocus sativus (Saffron) versus placebo and Fluoxetine in treating depression: a systematic review and meta-analysis. Psychol Res Behav Manag, 12: 297-305. Lopresti AL, Drummond PD. 2014. Saffron (Crocus sativus) for depression: a systematic review of clinical studies and examination of underlying antidepressant mechanisms of action. Hum Psychopharmacol, 29: 517-527. Maleki-Saghooni N, Mirzaeii K, Hosseinzadeh H, Sadeghi R, Irani M. 2018. A systematic review and metaanalysis of clinical trials on saffron (Crocus sativus) effectiveness and safety on erectile dysfunction and semen parameters. Avicenna J Phytomed, 8: 198- 209. Marx W, Lane M, Rocks T, Ruusunen A, Loughman A, Lopresti A, Marshall S, Berk M, Jacka F, Dean OM. 2019. Effect of saffron supplementation on symptoms of depression and anxiety: a systematic review and meta-analysis. Nutr Rev, 77: 557-571. McCloskey RJ, Reno R. 2019. Complementary health approaches for postpartum depression: A systematic review. Soc Work Ment Health, 17: 106- 128. Molkara T, Motavasselian M, Akhlaghi F, Ramezani MA, Naghedi Baghdar H, Ghazanfari SM, Salari R. 2020. The effects of herbal medicines on women sexual dysfunction: a systematic review. Curr Drug Discov Technol, 18: 7-16. Morgan AJ, Jorm AF. 2008. Self-help interventions for depressive disorders and depressive symptoms: a systematic review. Ann Gen Psychiatry, 7: 1-23. Mzabri I, Addi M, Berrichi A. 2019. Traditional and modern uses of saffron (Crocus sativus). Cosmetics, 6: 63-73. Newmaster SG, Grguric M, Shanmughanandhan D, Ramalingam S, Ragupathy S. 2013. DNA barcoding detects contamination and substitution in North American herbal products. BMC Med, 11: 1-13. Rameshrad M, Razavi BM, Hosseinzadeh H. 2018. Saffron and its derivatives, crocin, crocetin and safranal: a patent review. Expert Opin Ther Pat, 28: 147-165. Ranjbar H, Ashrafizaveh A. 2019. Effects of saffron (Crocus sativus) on sexual dysfunction among men and women: A systematic review and meta-analysis. Avicenna J Phytomed, 9: 419-427. Ren Y, Zhu C, Wu J. Zheng R, Cao H. 2015. Comparison between herbal medicine and fluoxetine for depression: a systematic review of randomized controlled trials. Complement Ther Med, 23: 674-684. Sarris J. 2007. Herbal medicines in the treatment of psychiatric disorders: a systematic review. Phytother Res, 21: 703-716. Shea BJ, Hamel C, Wells GA, Bouter LM, Kristjansson E, Grimshaw J, Henry DA, Boers M. 2009. AMSTAR is a reliable and valid measurement tool to assess the methodological quality of systematic reviews. J Clin Epidemiol, 62: 1013-1020. Solati K, Heidari-Soureshjani S, Luther T, Asadi-Samani M. 2017. Iranian medicinal plants effective on sexual disorders: A systematic review. Int J Pharm Sci Res, 8: 2415-2420. Srivastava R, Ahmed H, Dixit R. 2010. Crocus sativus L.: a comprehensive review. Pharmacogn Rev, 4: 200-208. Talebi M, Talebi M, Samarghandian S. 2021. Association of Crocus sativus with cognitive dysfunctions and Alzheimer's disease: a systematic review. Biointerface Res Appl Chem, 11: 7468-7492. Tóth B, Hegyi P, Lantos T, Szakács Z, Kerémi B, Varga G, Tenk J, Pétervári E, Balaskó M, Rumbus Z, Rakonczay Z, Bálint ER, Kiss T, Csupor D. 2019. The efficacy of saffron in the treatment of mild to moderate depression: a meta-analysis. Planta Med, 85: 24-31. Wasserstein RL, Lazar NA. 2016. The ASA statement on p-values: context, process, and purpose. Am Stat, 2: 129-133. Shamabadi et al. AJP, Vol. 12, No. 5, Sep-Oct 2022 488 Yang X, Chen X, Fu Y, Luo Q, Du L, Qiu H, Qiu T, Zhang L, Meng H. 2018. Comparative efficacy and safety of Crocus sativus L. for treating mild to moderate major depressive disorder in adults: a meta-analysis of randomized controlled trials. Neuropsychiatr Dis Treat, 14: 1297-1305. Yeung KS, Hernandez M, Mao JJ, Haviland I, Gubili J. 2018. Herbal medicine for depression and anxiety: A systematic review with assessment of potential psycho-oncologic relevance. Phytother Res, 32: 865-891. Zandi N, Pazoki B, Roudsari NM, Lashgari N-A, Jamshidi V, Momtaz S, Abdolghaffari AH, Akhondzadeh S. 2021. Prospects of saffron and its derivatives in Alzheimer's disease. Arch Iran Med, 3: 233-252 | ||
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