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Ghaznavi, Hamid, Emami, Hamid, Aallaveisi, Farzaneh, Shokrani, Parvaneh. (1401). Secondary Cancer Risk after Radiotherapy of Seminoma Stage One. , 19(3), 175-180. doi: 10.22038/ijmp.2021.57903.1971
Hamid Ghaznavi; Hamid Emami; Farzaneh Aallaveisi; Parvaneh Shokrani. "Secondary Cancer Risk after Radiotherapy of Seminoma Stage One". , 19, 3, 1401, 175-180. doi: 10.22038/ijmp.2021.57903.1971
Ghaznavi, Hamid, Emami, Hamid, Aallaveisi, Farzaneh, Shokrani, Parvaneh. (1401). 'Secondary Cancer Risk after Radiotherapy of Seminoma Stage One', , 19(3), pp. 175-180. doi: 10.22038/ijmp.2021.57903.1971
Ghaznavi, Hamid, Emami, Hamid, Aallaveisi, Farzaneh, Shokrani, Parvaneh. Secondary Cancer Risk after Radiotherapy of Seminoma Stage One. , 1401; 19(3): 175-180. doi: 10.22038/ijmp.2021.57903.1971

Secondary Cancer Risk after Radiotherapy of Seminoma Stage One

Iranian Journal of Medical Physics
مقاله 6، دوره 19، شماره 3، مرداد و شهریور 2022، صفحه 175-180    اصل مقاله (1.5 M)
نوع مقاله: Original Paper
شناسه دیجیتال (DOI): 10.22038/ijmp.2021.57903.1971
نویسندگان
Hamid Ghaznavi1؛ Hamid Emami2؛ Farzaneh Aallaveisi3؛ Parvaneh Shokrani* 4
1Department of Radiology, Faculty of Paramedical Sciences, Kurdistan University of Medical Sciences, Sanandaj, Iran.
2Department of Radiation Oncology, School of Medicine, Isfahan University of Medical Sciences. Isfahan, Iran,
3Department of Medical Physics, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.
4Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
چکیده
 
Introduction: In radiation treatment of stage one seminoma (SOS) induced secondary cancer in organs at risk (OARs), is late toxicity of major concern. This study aimed to compare the secondary cancer risk in radiotherapy of SOS in two-dimensional conventional (2D) radiation therapy and three-dimensional conformal radiation therapy (3DCRT).
Material and Methods: CT scan images of 10 patients with SOS were used to design 2D conventional and 3D conformal treatment plans using 25 Gy in 20 sessions. The life attributable risk (LAR) of the liver, stomach, and colon were calculated using the organ equivalent dose (OED) model for organs in the radiation field and the Biologic Effects of Ionizing Radiation VII (BEIR VII) model for organs out of the field.
Results: LAR of OARs in radiation fields such as the liver and stomach were obtained 40% higher in the 2D treatment than in the 3D treatment, while as for the colon, it was 17% lower in the 2D treatment than in the 3D treatment. The LAR values of kidneys located outside the radiation field in the 2D treatment were calculated at 0.04%.
Conclusion: Increasing the prescribed dose (25 vs. 20) as well as the number of treatment sessions (20 vs. 10) resulted in increase in the LAR of the liver, stomach, and colon. Therefore, estimating the cancer risk of critical organs exposed to radiation through examining the effects of dose fractionation and prescribed doses can be used in optimizing of the treatment plan for seminoma, selecting a better treatment method by oncologists, and patient follow-up.
کلیدواژه‌ها
Seminoma؛ Radiotherapy؛ Secondary Cancer Risk
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