The effects of aqueous extract of Aloe vera leaves on the gastric acid secretion and brain and intestinal water content following acetic acid- induced gastric ulcer in male rats | ||
| Avicenna Journal of Phytomedicine | ||
| مقاله 8، دوره 4، شماره 2، خرداد و تیر 2014، صفحه 137-143 اصل مقاله (233.27 K) | ||
| نوع مقاله: Original Research Article | ||
| شناسه دیجیتال (DOI): 10.22038/ajp.2014.1909 | ||
| نویسندگان | ||
| Zakieh Keshavarzi1؛ Taha Mohammad Rezapour2؛ Mehran Vatanchian1؛ Mohammad Zare Hesari2؛ Hadi Nabizade Haghighi2؛ Mostafa Izanlu2؛ Maryam Sabaghian3؛ Kaveh Shahveisi* 4 | ||
| 1Department of Physiology, School of Medicine, Bojnurd University of Medical Sciences, Bojnurd, I. R. Iran | ||
| 2Student Research Committee, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, I. R. Iran | ||
| 3Department of Physiology, North Khorasan University of Medical Sciences, Bojnurd, I. R. Iran | ||
| 4Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, I. R. Iran | ||
| چکیده | ||
| Objective: Gut–brain axis (GBA) is very important in creation and modulation of gastrointestinal problems. Aloe vera gel has gastroprotective properties. The purpose of this study was to evaluate the effect of aqueous extract of Aloe vera leaves on the gastric acid secretion and brain and intestinal water content following acetic acid gastric ulcer induction. Materials and Methods: Gastric ulcer was induced by injection of 20% acetic acid into the subserosal layer in male rats. Rats were randomly assigned into three groups: intact group, gastric ulcer group and Aloe vera group (treatment with Aloe vera following gastric ulcer induction). The acid levels and brain and intestinal water content of each sample were measured eight days after the gastric ulcer induction. Results: Gastric acid levels were significantly decreased in Aloe vera group when compared with gastric ulcer group (p<0.05). However, there were no differences in acid output between gastric ulcer and Aloe vera groups with intact group. After Aloe vera administration, the amount of brain water content had no difference with intact and gastric ulcer groups (p<0.05). The duodenal water content in Aloe vera group was significantly reduced compared with intact group (p<0.05) but gastric ulcer group had no significant difference with intact and Aloe vera group. Conclusions: The administration of Aloe vera has an inhibitory effect on the gastric acid output. | ||
| کلیدواژهها | ||
| Aloe vera؛ Brain water content؛ Gastric acid secretion؛ Peptic ulcer | ||
| مراجع | ||
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