Evaluation of Interleukin 33 and ST2 Serum Concentration in Active Tuberculosis Patients | ||
| Reviews in Clinical Medicine | ||
| دوره 8، شماره 3، آذر 2021، صفحه 106-110 اصل مقاله (542.92 K) | ||
| نوع مقاله: Original article | ||
| شناسه دیجیتال (DOI): 10.22038/rcm.2021.59643.1373 | ||
| نویسندگان | ||
| Masoud Youssefi1؛ Golsa Teimouri2؛ Farnaz Zahedi Avval3؛ kiarash ghazvini2؛ Masoud Keikha* 4 | ||
| 11.Department of Microbiology and Virology, School of Medicine, Mashhad University of Medical Science, Mashhad, Iran. 2.Antimicrobial Resistance Research Center, Bu-Ali Research Institute, Mashhad University of Medical Science, Mashhad, Iran. | ||
| 21.Department of Microbiology and Virology, School of Medicine, Mashhad University of Medical Science, Mashhad, Iran. 2. Antimicrobial Resistance Research Center, Bu-Ali Research Institute, Mashhad University of Medical Science, Mashhad, Iran. | ||
| 3Department of Biochemistry, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. | ||
| 41. Department of Microbiology and Virology, School of Medicine, Mashhad University of Medical Science, Mashhad, Iran. 2. Antimicrobial Resistance Research Center, Bu-Ali Research Institute, Mashhad University of Medical Science, Mashhad, Iran. | ||
| چکیده | ||
| The aim of this study was to determine the serum levels of ST2 protein and interleukin-33 in patients affected to tuberculosis and compare them with the control group. In the present study, at first 30 patients affected to TB were randomly selected and 52 healthy individuals, who were matched with respect to their age and gender, included in the study as the control group. After that, the serum levels of sST2 and IL33 were measured by ELISA sandwich method using commercial Quantikine Human ELISA kit (R&D Systems). The data were finally analyzed by SPSS software. IL-33 levels in the TB group were higher than the healthy controls and a statistically significant difference was observed in the IL-33 levels between the two groups (P = 0.021). Moreover, IL-33R (ST2) was slightly increased in the TB patients compared to the healthy controls, although statistical analysis showed no significant difference between the two groups (P = 0.083). Regarding the high normal variation of sST2 and the limitations of the present study, it is recommended that future studies of sST2 be performed in with higher number of TB patients. | ||
| کلیدواژهها | ||
| Active Pulmonary Tuberculosis؛ Cytokines؛ Tuberculosis | ||
|
آمار تعداد مشاهده مقاله: 278 تعداد دریافت فایل اصل مقاله: 212 |
||