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Boktor, Raef, Lee, Sze Ting, Berlangieri, Salvatore, Scott, Andrew. (1400). Impact of 18F-FDG PET/CT on treatment of patients with differentiated thyroid carcinoma, negative 131I whole body scan and elevated serum thyroglobulin. , 10(1), 20-27. doi: 10.22038/aojnmb.2021.58276.1406
Raef R Boktor; Sze Ting Lee; Salvatore U Berlangieri; Andrew M Scott. "Impact of 18F-FDG PET/CT on treatment of patients with differentiated thyroid carcinoma, negative 131I whole body scan and elevated serum thyroglobulin". , 10, 1, 1400, 20-27. doi: 10.22038/aojnmb.2021.58276.1406
Boktor, Raef, Lee, Sze Ting, Berlangieri, Salvatore, Scott, Andrew. (1400). 'Impact of 18F-FDG PET/CT on treatment of patients with differentiated thyroid carcinoma, negative 131I whole body scan and elevated serum thyroglobulin', , 10(1), pp. 20-27. doi: 10.22038/aojnmb.2021.58276.1406
Boktor, Raef, Lee, Sze Ting, Berlangieri, Salvatore, Scott, Andrew. Impact of 18F-FDG PET/CT on treatment of patients with differentiated thyroid carcinoma, negative 131I whole body scan and elevated serum thyroglobulin. , 1400; 10(1): 20-27. doi: 10.22038/aojnmb.2021.58276.1406

Impact of 18F-FDG PET/CT on treatment of patients with differentiated thyroid carcinoma, negative 131I whole body scan and elevated serum thyroglobulin

Asia Oceania Journal of Nuclear Medicine and Biology
مقاله 3، دوره 10، شماره 1، فروردین 2022، صفحه 20-27    اصل مقاله (1.11 M)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/aojnmb.2021.58276.1406
نویسندگان
Raef R Boktor1، 2، 3؛ Sze Ting Lee1، 2، 3؛ Salvatore U Berlangieri1؛ Andrew M Scott* 1، 2، 3، 4
1Department of Molecular Imaging and Therapy, Austin Health, Melbourne, VIC Australia
2Olivia Newton-John Cancer Research Institute, Melbourne, VIC, Australia
3School of Cancer Medicine, La Trobe University, Melbourne, VIC, Australia
4Faculty of Medicine, University of Melbourne, Melbourne, VIC, Australia
چکیده
Objective(s): 18F-FDG PET/CT is increasingly performed in patients with differen-tiated thyroid cancer. The aim of this study was to assess the clinical impact of 18F-FDG PET/CT on the management of patients with differentiated thyroid carcinoma who had elevated serum thyroglobulin (Tg) and negative 131I whole body scan (WBS).
Methods: 67 patients with differentiated thyroid carcinoma were included in this study. The findings of 18F-FDG PET/CT imaging were compared with histo-pathology, follow up imaging, or clinical follow-up results. The diagnostic accuracy of 18F-FDG PET/CT was evaluated for the entire patient group and for those patients with stimulated serum thyroglobulin levels of less than 5, 5–10, and more than 10 pmol/L as well as for local recurrences and metastases sites. The impact of 18F-FDG PET/CT on therapeutic management was also evaluated.
Results: 30/67 patients had positive findings on 18F-FDG PET/CT; 28 were true-positive and 2 were false-positive. 18F-FDG PET/CT results were true-negative in 36 patients and false-negative in 1 patient. The overall sensitivity, specificity, accuracy, PPV and NPV of 18F-FDG PET/CT were, 96.5%, 94.5%, 95.5%, 93.3%, and 97.2% respectively. Positive 18F-FDG PET/CT findings were directly correlated with stimulated serum thyroglobulin levels, 7.1% had Tg between 5–10, and 92.9% had Tg greater than 10 pmol/L. 18F-FDG PET/CT had a high or moderate impact on treatment management in 28 (41.8%) of patients.
Conclusion: 18F-FDG PET/CT is able to improve diagnostic accuracy and have management impact in a therapeutically relevant way in patients with differentiated thyroid carcinoma who present with rising thyroglobulin level, negative 131I WBS, and clinical suspicion of recurrent disease.
کلیدواژه‌ها
FDG PET؛ Thyroglobulin؛ 131I؛ Thyroid carcinoma
مراجع
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