سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Akkawi, Abdul Rahman, Ezzeddine, Lynn, Chahinian, Rita, Ershaid, Firas, Merheb, Diala, Mzeihem, Majd, El Cheikh, Jean, Haidar, Mohamad. (1400). Hepatic granuloma mimicking recurrent lymphoma on 18F-FDG PET/CT in a patient with primary mediastinal diffuse large B-cell lymphoma. , 10(1), 47-52. doi: 10.22038/aojnmb.2021.56876.1396
Abdul Rahman Akkawi; Lynn Ezzeddine; Rita Chahinian; Firas Ershaid; Diala Merheb; Majd Mzeihem; Jean El Cheikh; Mohamad Haidar. "Hepatic granuloma mimicking recurrent lymphoma on 18F-FDG PET/CT in a patient with primary mediastinal diffuse large B-cell lymphoma". , 10, 1, 1400, 47-52. doi: 10.22038/aojnmb.2021.56876.1396
Akkawi, Abdul Rahman, Ezzeddine, Lynn, Chahinian, Rita, Ershaid, Firas, Merheb, Diala, Mzeihem, Majd, El Cheikh, Jean, Haidar, Mohamad. (1400). 'Hepatic granuloma mimicking recurrent lymphoma on 18F-FDG PET/CT in a patient with primary mediastinal diffuse large B-cell lymphoma', , 10(1), pp. 47-52. doi: 10.22038/aojnmb.2021.56876.1396
Akkawi, Abdul Rahman, Ezzeddine, Lynn, Chahinian, Rita, Ershaid, Firas, Merheb, Diala, Mzeihem, Majd, El Cheikh, Jean, Haidar, Mohamad. Hepatic granuloma mimicking recurrent lymphoma on 18F-FDG PET/CT in a patient with primary mediastinal diffuse large B-cell lymphoma. , 1400; 10(1): 47-52. doi: 10.22038/aojnmb.2021.56876.1396

Hepatic granuloma mimicking recurrent lymphoma on 18F-FDG PET/CT in a patient with primary mediastinal diffuse large B-cell lymphoma

Asia Oceania Journal of Nuclear Medicine and Biology
مقاله 7، دوره 10، شماره 1، فروردین 2022، صفحه 47-52    اصل مقاله (1.32 M)
نوع مقاله: Case report
شناسه دیجیتال (DOI): 10.22038/aojnmb.2021.56876.1396
نویسندگان
Abdul Rahman Akkawi1؛ Lynn Ezzeddine2؛ Rita Chahinian1؛ Firas Ershaid1؛ Diala Merheb1؛ Majd Mzeihem1؛ Jean El Cheikh3؛ Mohamad Haidar* 1
1Department of Clinical Diagnostic Radiology, American University of Beirut Medical Center, Beirut, Lebanon
2Department of Diagnostic Radiology, Saint George Hospital University Medical Center, University of Balamand, Beirut, Lebanon
3Department of Internal Medicine, Division of Hematology/Oncology, American University of Beirut Medical Center, Beirut, Lebanon
چکیده
18F-Flurodeoxyglucose (FDG) PET/CT has been considered the modality of choice in detecting, staging, restaging and following-up with lymphoma patients. However, it has an uncertain role in differentiating hepatic lymphomatous relapse from other granulomatous diseases such as in candidiasis or sarcoidosis. Therefore, it is important to correlate the imaging findings with other modalities such as ultrasound, CT scan, MRI, and histology to direct the diagnosis and treatment. We present a case of a 33-year-old woman with large B-cell lymphoma in complete remission following treatment presenting with neutropenic fever following her final cycle of chemotherapy. Ultrasound of the abdomen and enhanced CT scan of the abdomen and pelvis were negative. The FDG PET/CT scan showed multiple FDG-avid hypodense hepatic lesions that were suggestive either of lymphoproliferative involvement or nonmalignant process. However, MRI of the abdomen performed four days later was suggestive of an infectious process, rather than a lymphoproliferative disorder. A subsequent CT-guided biopsy of a hepatic lesion showed granulomatous inflammation, with no evidence of malignancy or Tuberculosis. The patient was started on Caspofungin followed by Fluconazole. After 5 weeks, the clinical condition resolved, and the subsequent FDG PET/CT showed complete resolution of the FDG-avid multiple hepatic lesions.
کلیدواژه‌ها
F-18 PET CT؛ Large B cell lymphoma؛ Hepatic granuloma؛ Hepatic candidiasis
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