Abdel-Salam, Omar, El-Shamarka, Marwa, Youness, Eman, Shaffie, Nermeen. (1400). Inhibition of aluminum chloride-induced amyloid Aβ peptide accumulation and brain neurodegeneration by Bougainvillea spectabilis flower decoction. , 24(10), 1437-1445. doi: 10.22038/ijbms.2021.58246.12940
Omar Abdel-Salam; Marwa El-Shamarka; Eman Youness; Nermeen Shaffie. "Inhibition of aluminum chloride-induced amyloid Aβ peptide accumulation and brain neurodegeneration by Bougainvillea spectabilis flower decoction". , 24, 10, 1400, 1437-1445. doi: 10.22038/ijbms.2021.58246.12940
Abdel-Salam, Omar, El-Shamarka, Marwa, Youness, Eman, Shaffie, Nermeen. (1400). 'Inhibition of aluminum chloride-induced amyloid Aβ peptide accumulation and brain neurodegeneration by Bougainvillea spectabilis flower decoction', , 24(10), pp. 1437-1445. doi: 10.22038/ijbms.2021.58246.12940
Abdel-Salam, Omar, El-Shamarka, Marwa, Youness, Eman, Shaffie, Nermeen. Inhibition of aluminum chloride-induced amyloid Aβ peptide accumulation and brain neurodegeneration by Bougainvillea spectabilis flower decoction. , 1400; 24(10): 1437-1445. doi: 10.22038/ijbms.2021.58246.12940

Inhibition of aluminum chloride-induced amyloid Aβ peptide accumulation and brain neurodegeneration by Bougainvillea spectabilis flower decoction

Iranian Journal of Basic Medical Sciences
دوره 24، شماره 10، دی 2021، صفحه 1437-1445    اصل مقاله (988.22 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2021.58246.12940
نویسندگان
Omar Abdel-Salam* 1؛ Marwa El-Shamarka1؛ Eman Youness2؛ Nermeen Shaffie3
1Department of Toxicology and Narcotics, National Research Centre, Cairo, Egypt
2Department of Medical Biochemistry, National Research Centre, Cairo, Egypt
3Department of Pathology, National Research Centre, Cairo, Egypt
چکیده
Objective(s): To investigate the potential therapeutic effect of Bougainvillea spectabilis flower decoction on aluminum chloride (AlCl3)-induced neurotoxicity. 
Materials and Methods: Rats received daily intraperitoneal injections of AlCl3 at 10 mg/kg for two months and were treated with B. spectabilis decoction at 50 or 100 mg/kg or saline during the 2nd month of the study. The control group received saline. Brain malondialdehyde (MDA), nitric oxide (NO), reduced glutathione (GSH), acetylcholinesterase (AChE), amyloid Aβ peptide, and interleukin-6 (IL-6) concentrations and paraoxonase-1 (PON-1) activity were determined and brain histology was done. Behavioral and neurological testing included Morris water maze (WMZ), Y maze, and wire hanging. 
Results: Compared with saline controls, AlCl3 significantly increased brain MDA and NO along with decreased GSH and PON-1 activity. It also increased AChE, IL-6, and amyloid Aβ concentrations. AlCl3 impaired motor strength and memory performance and caused brain neurodegeneration. B. spectabilis decoction given at 50 or 100 mg/kg protected against the biochemical and histopathological alterations evoked by AlCl3 by alleviating the increase in MDA and NO, and decrease in GSH and PON-1 activity.  B. spectabilis decoction showed no significant effect on AChE but markedly decreased IL-6 and amyloid Aβ in the brain of AlCl3-treated rats. It also restored memory performance and motor strength, and protected against AlCl3-induced neurodegeneration.
Conclusion: These results suggest that B. spectabilis flower decoction might prove of value in the treatment of Alzheimer’s disease.
کلیدواژه‌ها
Aluminum chloride؛ Amyloid Aβ؛ Bougainvillea spectabilis- flowers؛ Interleukin-6؛ Neurodegeneration؛ Oxidative stress؛ Paraoxonase
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