Tunca, Ulker, Saygin, Mustafa, Ozmen, Ozlem, Aslankoc, Rahime, Yalcin, Arzu. (1400). The impact of moderate-intensity swimming exercise on learning and memory in aged rats: The role of Sirtuin-1. , 24(10), 1413-1420. doi: 10.22038/ijbms.2021.58145.12920
Ulker Tunca; Mustafa Saygin; Ozlem Ozmen; Rahime Aslankoc; Arzu Yalcin. "The impact of moderate-intensity swimming exercise on learning and memory in aged rats: The role of Sirtuin-1". , 24, 10, 1400, 1413-1420. doi: 10.22038/ijbms.2021.58145.12920
Tunca, Ulker, Saygin, Mustafa, Ozmen, Ozlem, Aslankoc, Rahime, Yalcin, Arzu. (1400). 'The impact of moderate-intensity swimming exercise on learning and memory in aged rats: The role of Sirtuin-1', , 24(10), pp. 1413-1420. doi: 10.22038/ijbms.2021.58145.12920
Tunca, Ulker, Saygin, Mustafa, Ozmen, Ozlem, Aslankoc, Rahime, Yalcin, Arzu. The impact of moderate-intensity swimming exercise on learning and memory in aged rats: The role of Sirtuin-1. , 1400; 24(10): 1413-1420. doi: 10.22038/ijbms.2021.58145.12920

The impact of moderate-intensity swimming exercise on learning and memory in aged rats: The role of Sirtuin-1

Iranian Journal of Basic Medical Sciences
دوره 24، شماره 10، دی 2021، صفحه 1413-1420    اصل مقاله (1.36 M)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2021.58145.12920
نویسندگان
Ulker Tunca* 1؛ Mustafa Saygin1؛ Ozlem Ozmen2؛ Rahime Aslankoc1؛ Arzu Yalcin1
1Suleyman Demirel University, Faculty of Medicine, Department of Physiology, Isparta, Turkey
2Department of Pathology, Faculty of Veterinary Medicine, Burdur Mehmet Akif Ersoy University, Burdur, Turkey
چکیده
Objective(s): The purpose of this study was to evaluate the effect of moderate-intensity swimming exercise on learning and memory by the Morris water maze test. Changes in the expressions of cyclic AMP-response element-binding protein (CREB) and brain-derived neurotrophic factor (BDNF) proteins alternative pathway which were activated by sirtuin-1 (SIRT-1) were investigated.
Materials and Methods: The study included thirty-two male Sprague-Dawley rats (350-500 g, 11-12 and 15–16 months old). The rats were randomly divided into four groups with 8 rats in each group. The groups were designed as follows:  Control-1 (11-12 months), Exercise-1 (11-12 months), Control-2 (15-16 months), Exercise-2 (15-16 months). Moderate-intensity exercise was assigned for 30 min/day, 5 days/week, for the whole training period of 8 weeks.
Results: There were statistically significant differences between the groups on the third day (P=0.005) when swim speeds increased in the exercise groups. There was a statistically significant difference between Exercise 1 and Exercise 2 groups, the entries in the platform zone decreased in Exercise 2 group (P=0.026). While there were no histopathological findings observed in any group, increased  SIRT-1, BNDF, and CREB  expressions were seen in exercise groups compared with control groups.
Conclusion: In aged rats exercising at moderate intensity, increased expression of CREB and BDNF, and SIRT-1 could improve hippocampal-dependent memory.
کلیدواژه‌ها
BDNF؛ CREB؛ Learning-memory؛ Sirtuin-1؛ Swimming exercise
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