Tsai, Sheng-Ta, Wei, Tzu-Hsuan, Yang, Yu-Wan, Lu, Ming-Kuei, San, Shao, Tsai, Chon-Haw, Lin, Yi-Wen. (1400). Transient receptor potential V1 modulates neuroinflammation in Parkinson’s disease dementia: Molecular implications for electroacupuncture and rivastigmine. , 24(10), 1336-1345. doi: 10.22038/ijbms.2021.56156.12531
Sheng-Ta Tsai; Tzu-Hsuan Wei; Yu-Wan Yang; Ming-Kuei Lu; Shao San; Chon-Haw Tsai; Yi-Wen Lin. "Transient receptor potential V1 modulates neuroinflammation in Parkinson’s disease dementia: Molecular implications for electroacupuncture and rivastigmine". , 24, 10, 1400, 1336-1345. doi: 10.22038/ijbms.2021.56156.12531
Tsai, Sheng-Ta, Wei, Tzu-Hsuan, Yang, Yu-Wan, Lu, Ming-Kuei, San, Shao, Tsai, Chon-Haw, Lin, Yi-Wen. (1400). 'Transient receptor potential V1 modulates neuroinflammation in Parkinson’s disease dementia: Molecular implications for electroacupuncture and rivastigmine', , 24(10), pp. 1336-1345. doi: 10.22038/ijbms.2021.56156.12531
Tsai, Sheng-Ta, Wei, Tzu-Hsuan, Yang, Yu-Wan, Lu, Ming-Kuei, San, Shao, Tsai, Chon-Haw, Lin, Yi-Wen. Transient receptor potential V1 modulates neuroinflammation in Parkinson’s disease dementia: Molecular implications for electroacupuncture and rivastigmine. , 1400; 24(10): 1336-1345. doi: 10.22038/ijbms.2021.56156.12531

Transient receptor potential V1 modulates neuroinflammation in Parkinson’s disease dementia: Molecular implications for electroacupuncture and rivastigmine

Iranian Journal of Basic Medical Sciences
دوره 24، شماره 10، دی 2021، صفحه 1336-1345    اصل مقاله (1.22 M)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2021.56156.12531
نویسندگان
Sheng-Ta Tsai1، 2، 3؛ Tzu-Hsuan Wei4؛ Yu-Wan Yang1، 5؛ Ming-Kuei Lu1، 3، 5؛ Shao San6؛ Chon-Haw Tsai1، 3، 5؛ Yi-Wen Lin* 2، 7
1Department of Neurology, China Medical University Hospital, Taichung, Taiwan
2Graduate Institute of Acupuncture Science, College of Chinese Medicine, China Medical University, Taichung, Taiwan
3Everflourish Neuroscience and Brain Disease Center, China Medical University Hospital, Taichung, Taiwan
4Department of Chinese Medicine, China Medical University Hospital, Taichung, Taiwan
5College of Medicine, China Medical University, Taichung, Taiwan
6Department of Psychiatry, Taoyuan Psychiatric Center, Ministry of Health and Welfare, Taoyuan, Taiwan
7Chinese Medicine Research Center, China Medical University, Taichung, Taiwan
چکیده
Objective(s): Parkinson’s disease (PD) is a common progressive neurodegeneration disease. Its incidence increases with age and affects about 1% of people over 60. Incidentally, transient receptor potential V1 (TRPV1) and its relation with neuroinflammation in mouse brain has been widely reported.
Materials and Methods: We used 6-hydroxydopamine (6-OHDA) to induce PDD in mice. We then used the Morris water maze and Bio-Plex to test learning and inflammatory mediators in mouse plasma. Western blotting and immunostaining were used to examine TRPV1 pathway in the hippocampus and medial prefrontal cortex (mPFC).
Results: On acquisition days 3 (Control = 4.40 ± 0.8 sec, PDD = 9.82 ± 1.52 sec, EA = 5.04 ± 0.58 sec, Riva = 4.75 ± 0.87 sec; P=0.001) and 4, reversal learning days 1, 2, 3 (Control = 2.86 ± 0.46 sec, PDD = 9.80 ± 1.83 sec, EA = 4.6 ± 0.82 sec, Riva = 4.6 ± 1.03 sec; P=0.001) and 4, PDD mice showed significantly longer escape latency than the other three groups. Results showed that several cytokines were up-regulated in PDD mice and reversed by EA and rivastigmine. TRPV1 and downstream molecules were up-regulated in PDD mice and further reversed by EA and rivastigmine. Interestingly, α7 nicotinic receptors and parvalbumin levels in both the hippocampus and prefrontal cortex increased in EA-treated mice, but not in rivastigmine-treated mice.
Conclusion: Our results showed that TRPV1 played a role in the modulation of neuroinflammation of PDD, and could potentially be a new target for treatment.
کلیدواژه‌ها
Electroacupuncture؛ Hippocampus؛ Neuroinflammation؛ Parkinson’s disease dementia؛ Rivastigmine؛ Transient receptor potential V1
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