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Rafiei, Mohammad Mahdi, Soltani, Raheleh, Kordi, Mohamadreza, Nouri, Reza, Gaeini, Abbasali. (1400). Gene expression of angiogenesis and apoptotic factors in female BALB/c mice with breast cancer after eight weeks of aerobic training. , 24(9), 1196-1202. doi: 10.22038/ijbms.2021.55582.12427
Mohammad Mahdi Rafiei; Raheleh Soltani; Mohamadreza Kordi; Reza Nouri; Abbasali Gaeini. "Gene expression of angiogenesis and apoptotic factors in female BALB/c mice with breast cancer after eight weeks of aerobic training". , 24, 9, 1400, 1196-1202. doi: 10.22038/ijbms.2021.55582.12427
Rafiei, Mohammad Mahdi, Soltani, Raheleh, Kordi, Mohamadreza, Nouri, Reza, Gaeini, Abbasali. (1400). 'Gene expression of angiogenesis and apoptotic factors in female BALB/c mice with breast cancer after eight weeks of aerobic training', , 24(9), pp. 1196-1202. doi: 10.22038/ijbms.2021.55582.12427
Rafiei, Mohammad Mahdi, Soltani, Raheleh, Kordi, Mohamadreza, Nouri, Reza, Gaeini, Abbasali. Gene expression of angiogenesis and apoptotic factors in female BALB/c mice with breast cancer after eight weeks of aerobic training. , 1400; 24(9): 1196-1202. doi: 10.22038/ijbms.2021.55582.12427

Gene expression of angiogenesis and apoptotic factors in female BALB/c mice with breast cancer after eight weeks of aerobic training

Iranian Journal of Basic Medical Sciences
مقاله 5، دوره 24، شماره 9، آذر 2021، صفحه 1196-1202    اصل مقاله (767.08 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2021.55582.12427
نویسندگان
Mohammad Mahdi Rafiei1؛ Raheleh Soltani1؛ Mohamadreza Kordi2؛ Reza Nouri* 1؛ Abbasali Gaeini2
1Department of Sport Sciences, Kish International Campus, University of Tehran, Kish, Iran
2Department of Exercise Physiology, Faculty of Sport Sciences, University of Tehran, Tehran, Iran
چکیده
Objective(s): Breast cancer is the most common cancer in women, caused by a disorder in the angiogenesis and apoptosis process. Exercise can affect the process of angiogenesis and apoptosis in the tumor tissue. Thus, the aim of the present study was to investigate the changes in angiogenesis and apoptotic factors in mice with breast cancer after 8 weeks of exercise training.
Materials and Methods: Sixteen females BALB/c mice (age: 3-5 weeks and weight: 17.1 ± 0.1 g) with breast cancer were randomly divided into two groups of aerobic training and control. The aerobic training included 8 weeks and 5 sessions per week of running with an intensity of 14-20 m.min-1. HIF-1α, VEGF, miR-21 and cytochrome C, Apaf-1, caspase-9, and caspase-3 gene expressions were examined by real-time PCR. Repeated measures ANOVA, Bonferroni’s post hoc test, and independent samples t-test were used to analyze the data (p <0.05).
Results: The results showed that aerobic training reduced the growth of tumor volume and significantly reduced miR-21 gene expression. Aerobic training also significantly increased the gene expression of HIF-1α, cytochrome C, Apaf-1, caspase-9, and caspase-3, while changes in VEGF gene expression were not statistically significant.
Conclusion: It appears that aerobic exercise training reduces tumor size and ameliorates breast cancer by reducing miR-21 gene expression, suppressing the apoptosis process, and reducing angiogenesis.
کلیدواژه‌ها
Aerobic exercise؛ Angiogenesis؛ Apoptosis؛ Breast Cancer؛ Gene expression
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