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Zaeri, Sasan, Karami, Fatemeh, Assadi, Majid. (1400). Propranolol-loaded electrospun nanofibrous wound dressing: From fabrication and characterization to preliminary wound healing evaluation. , 24(9), 1279-1291. doi: 10.22038/ijbms.2021.57770.12857
Sasan Zaeri; Fatemeh Karami; Majid Assadi. "Propranolol-loaded electrospun nanofibrous wound dressing: From fabrication and characterization to preliminary wound healing evaluation". , 24, 9, 1400, 1279-1291. doi: 10.22038/ijbms.2021.57770.12857
Zaeri, Sasan, Karami, Fatemeh, Assadi, Majid. (1400). 'Propranolol-loaded electrospun nanofibrous wound dressing: From fabrication and characterization to preliminary wound healing evaluation', , 24(9), pp. 1279-1291. doi: 10.22038/ijbms.2021.57770.12857
Zaeri, Sasan, Karami, Fatemeh, Assadi, Majid. Propranolol-loaded electrospun nanofibrous wound dressing: From fabrication and characterization to preliminary wound healing evaluation. , 1400; 24(9): 1279-1291. doi: 10.22038/ijbms.2021.57770.12857

Propranolol-loaded electrospun nanofibrous wound dressing: From fabrication and characterization to preliminary wound healing evaluation

Iranian Journal of Basic Medical Sciences
مقاله 15، دوره 24، شماره 9، آذر 2021، صفحه 1279-1291    اصل مقاله (2.11 M)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2021.57770.12857
نویسندگان
Sasan Zaeri* 1؛ Fatemeh Karami2؛ Majid Assadi3
1Department of Pharmacology, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
2Department of Pharmacology, School of Pharmacy, Eastern Mediterranean University, Famagusta, North Cyprus
3Nuclear Medicine and Molecular Imaging Research Center, Bushehr University of Medical Sciences, Bushehr, Iran
چکیده
Objective(s): The wound healing potential of beta-blocker drugs such as propranolol (PNL) has recently attracted attention. To date, incorporation of PNL into electrospun nanofibrous wound dressing mats has not been tested as a novel topical drug delivery system. Presently, electrospun nanofibrous mats loaded with PNL were fabricated, and their physicochemical properties and wound healing activities were evaluated.
Materials and Methods: Polyvinyl alcohol solutions containing 0, 2% or 4% (wt/vol) PNL were electrospun into mats, and the physicochemical properties and PNL release were evaluated. In vitro biocompatibility of selected PNL-loaded mats was tested in human foreskin fibroblasts and wound healing capability was evaluated in mouse skin wounds.
Results: The 4% PNL mat had thin fibers (160 nm), convincing porosity (79.5%), and good hydrophilicity (swelling: 89.1%, water contact angle: 42.1°) with little degradability (14.2%). The release of PNL was not in bursts and was best explained by the Korsmeyer–Peppas equation (R2 = 0.96, n = 0.40), suggesting Fickian release. The viability of fibroblasts was 173% on day 5 of incubation with 4% PNL mats, indicating good mat biocompatibility. In vivo treatment for 14 days with 4% PNL mats resulted in wounds with a surface area of only 9% of the original wound area. These wounds had better histopathologic characteristics and were associated with less oxidative stress.
Conclusion: The wound dressing fabricated with 4% PNL showed good potential for wound healing because of a favorable drug release profile from the nanofiber scaffold, and can be considered eligible for further clinical research. 
کلیدواژه‌ها
Electrospun nanofiber؛ Fibroblast؛ Mouse؛ Oxidative stress؛ Propranolol؛ Wound
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