Effects of quercetin on spatial memory, hippocampal antioxidant defense and BDNF concentration in a rat model of Parkinson’s disease: An electrophysiological study | ||
Avicenna Journal of Phytomedicine | ||
دوره 11، شماره 6، بهمن و اسفند 2021، صفحه 599-609 اصل مقاله (913.15 K) | ||
نوع مقاله: Original Research Article | ||
شناسه دیجیتال (DOI): 10.22038/ajp.2021.18526 | ||
نویسندگان | ||
Mehrdad Naghizadeh1؛ Mohammad Ali Mirshekar* 2؛ Farzaneh Montazerifar1؛ Saiedeh Saadat2؛ Ali Shamsi Koushki1؛ Saber Jafari Maskouni1؛ Maryam Afsharfar1؛ Saiedeh Arabmoazzen3 | ||
1Department of Food Sciences and Nutrition, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran | ||
2Department of Physiology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran | ||
3Deputy of Research and Technology, Zahedan University of Medical Sciences, Zahedan, Iran | ||
چکیده | ||
Objective: Quercetin is one of the most popular flavonoid with protective effects against neural damages in Parkinson's disease (PD). We assessed the effect of quercetin administration on memory and motor function, hippocampal oxidative stress and brain-derived neurotrophic factor (BDNF) level in a 6-OHDA-induced Parkinson's rat model. Material and Methods: The animals were divided into the following five groups (n=8): control, sham-surgery (sham), lesion (PD), and lesion animals treated with quercetin at doses of 10 (Q10) and 25 (Q25) mg/kg. For induction of a model of PD, 6-OHDA was injected into the striatum of rats. The effects of quercetin were investigated on spatial memory, hippocampal BDNF and malondialdehyde (MDA) levels, and total antioxidant capacity (TAC). Spatial memory was assessed by Morris water maze test, and the neuronal firing frequency in hippocampal dentate gyrus (HDG) was evaluated by single-unit recordings. Results: Mean path length and latency time, rotational behavior and hippocampal MDA concentration were significantly increased, while time spent in the goal quadrant, swimming speed, spike rate, and hippocampal levels of TAC and BDNF were significantly decreased in the PD group compared to the sham group (p<0.01 to p<0.001). Quercetin treatment significantly enhanced time spent in goal quadrant (p<0.05), swimming speed (p<0.001) and spike rate (p<0.01), improved hippocampal TAC (p<0.05 to p<0.001) and BDNF (p<0.01 to p<0.001) level, and decreased mean path length (p<0.001), latency time (p<0.05 to p<0.001), rotational behavior and hippocampal MDA concentration (p<0.05). Conclusion: The cognitive-enhancing effect of quercetin might be due to its antioxidant effects in the hippocampus. | ||
کلیدواژهها | ||
Quercetin؛ Parkinson’s disease؛ Spatial memory؛ Oxidative stress | ||
مراجع | ||
Amália PM, Possa MN, Augusto MC, Francisca LSJDd, sciences. 2007. Quercetin prevents oxidative stress in cirrhotic rats. Dig Dis Sci, 52: 2616-2621. Arbabi E, Hamidi G, Talaei SA, Salami MJIjobms. 2016. Estrogen agonist genistein differentially influences the cognitive and motor disorders in an ovariectomized animal model of Parkinsonism. Iran J Basic Med Sci, 19: 1285. Ay M, Luo J, Langley M, Jin H, Anantharam V, Kanthasamy A, Kanthasamy AG. 2017. Molecular mechanisms underlying protective effects of quercetin against mitochondrial dysfunction and progressive dopaminergic neurodegeneration in cell culture and MitoPark transgenic mouse models of Parkinson's Disease. J Neurochem, 141: 766-782. Barichella M, Cereda E, Pezzoli GJMd. 2009. Major nutritional issues in the management of Parkinson's disease. Mov Disord, 24: 1881-1892. Cattaneo E, Zuccato C, Tartari M. 2005. Normal huntingtin function: an alternative approach to Huntington's disease. Nat Rev Neurosci, 6: 919-930. Chang K-H, Chen C-M. 2020. The Role of Oxidative Stress in Parkinson’s Disease. Antioxidants, 9: 597. Creese I, Burt DR, Snyder SH. 1977. Dopamine receptor binding enhancement accompanies lesion-induced behavioral supersensitivity. Science, 197: 596-598. De Leonibus E, Pascucci T, Lopez S, Oliverio A, Amalric M, Mele AJP. 2007. Spatial deficits in a mouse model of Parkinson disease. Psychopharmacology, 194: 517- 525. Guo JD, Zhao X, Li Y, Li GR, Liu XL. 2018. Damage to dopaminergic neurons by oxidative stress in Parkinson's disease. Int J Mol Med, 41: 1817-1825. Haleagrahara N, Siew CJ, Mitra NK, Kumari MJNl. 2011. Neuroprotective effect of bioflavonoid quercetin in 6- hydroxydopamine-induced oxidative stress biomarkers in the rat striatum. Neurosci Lett, 500: 139-143. Hu LF, Lu M, Tiong CX, Dawe GS, Hu G, Bian JSJAc. 2010. Neuroprotective effects of hydrogen sulfide on Parkinson’s disease rat models. Aging cell, 9: 135-146. Naghizadeh et al. AJP, Vol. 11, No. 6, Nov-Dec 2021 608 Huang J, Zhu M, Tao Y, Wang S, Chen J, Sun W, Li SJJoP, Pharmacology. 2012. Therapeutic properties of quercetin on monosodium urate crystal‐induced inflammation in rat. J Pharm Pharmacol, 64: 1119-1127. Karuppagounder S, Madathil S, Pandey M, Haobam R, Rajamma U, Mohanakumar K. 2013. Quercetin up-regulates mitochondrial complex-I activity to protect against programmed cell death in rotenone model of Parkinson’s disease in rats. Neuroscience, 236: 136-148. Kim JJ, Clark RE, Thompson RF. 1995. Hippocampectomy impairs the memory of recently, but not remotely, acquired trace eyeblink conditioned responses. Behavioral neuroscience, 109: 195. Kumar R, Agarwal AK, Seth PKJJon. 1995. Free radical‐generated neurotoxicity of 6‐ hydroxydopamine. J Neurochem, 64: 1703- 1707. Lev N, Barhum Y, Ben-Zur T, Melamed E, Steiner I, Offen D. 2013. Knocking out DJ1 attenuates astrocytes neuroprotection against 6-hydroxydopamine toxicity. J Mol Neurosci, 50: 542-550. Miranda M, Morici JF, Zanoni MB, Bekinschtein P. 2019. Brain-derived neurotrophic factor: a key molecule for memory in the healthy and the pathological brain. Frontiers in cellular neuroscience, 13: 363. Mirshekar MA, Sarkaki A, Farbood Y, Naseri MKG, Badavi M, Mansouri MT, Haghparast A. 2018. Neuroprotective effects of gallic acid in a rat model of traumatic brain injury: behavioral, electrophysiological, and molecular studies. Iran J Basic Med Sci, 21: 1056. Narayanan NS, Rodnitzky RL, Uc EY. 2013. Prefrontal dopamine signaling and cognitive symptoms of Parkinson’s disease. Rev Neurosci, 24: 267-278. Nokia MS, Gureviciene I, Waselius T, Tanila H, Penttonen M. 2017. Hippocampal electrical stimulation disrupts associative learning when targeted at dentate spikes. J Physiol, 595: 4961-4971. O’Neill M, Brown VJJNol, memory. 2007. The effect of striatal dopamine depletion and the adenosine A2A antagonist KW-6002 on reversal learning in rats. Neurobiol Learn Mem, 88: 75-81. Ola MS, Ahmed MM, Shams S, Al-Rejaie SS. 2017. Neuroprotective effects of quercetin in diabetic rat retina. Saudi J Biol Sci, 24: 1186-1194. Paxinos G, Watson C 2006. The rat brain in stereotaxic coordinates: hard cover edition, Academic press. Prasad J, Baitharu I, Sharma AK, Dutta R, Prasad D, Singh S. 2013. Quercetin reverses hypobaric hypoxia-induced hippocampal neurodegeneration and improves memory function in the rat. High Alt Med Biol, 14: 383-394. Pu F, Mishima K, Irie K, Motohashi K, Tanaka Y, Orito K, Egawa T, Kitamura Y, Egashira N, Iwasaki K. 2007. Neuroprotective effects of quercetin and rutin on spatial memory impairment in an 8-arm radial maze task and neuronal death induced by repeated cerebral ischemia in rats. J Pharmacol Sci, 4: 329- 334. Rahmani F, Saghazadeh A, Rahmani M, Teixeira AL, Rezaei N, Aghamollaii V, Ardebili HE. 2019. Plasma levels of brainderived neurotrophic factor in patients with Parkinson disease: A systematic review and meta-analysis. Brain Res, 1704: 127-136. Rahvar M, Owji AA, Mashayekhi FJ. 2018. Effect of quercetin on the brain-derived neurotrophic factor gene expression in the rat brain. Bratisl Lek Listy, 119: 28-31. Russo-Neustadt AA, Chen MJ. 2005. Brainderived neurotrophic factor and antidepressant activity. Curr Pharm Des, 11: 1495-1510. Schober A. 2004. Classic toxin-induced animal models of Parkinson's disease: 6-OHDA and MPTP. Cell Tissue Res, 318: 215-224. Schwarting R, Huston J. 1996. The unilateral 6- hydroxydopamine lesion model in behavioral brain research. Analysis of functional deficits, recovery and treatments. Prog Neurobiol, 50: 275-331. Selvakumar K, Bavithra S, Krishnamoorthy G, Arunakaran J. 2018. Impact of quercetin on tight junctional proteins and BDNF signaling molecules in hippocampus of PCBs-exposed rats. Interdiscip Toxicol, 11: 294-305. Shim JS, Kim HG, Ju MS, Choi JG, Jeong SY, Oh MS. 2009. Effects of the hook of Uncaria rhynchophylla on neurotoxicity in the 6- hydroxydopamine model of Parkinson's disease. J Ethnopharmacol, 126: 361-365. Sriraksa N, Wattanathorn J, Muchimapura S, Tiamkao S, Brown K, Chaisiwamongkol Effect of quercetin on cognition in a rat model of Parkinson’s disease AJP, Vol. 11, No. 6, Nov-Dec 2021 609 KJE-BC, Medicine A. 2012. Cognitiveenhancing effect of quercetin in a rat model of Parkinson's disease induced by 6- hydroxydopamine. BMC Complement Altern Med, 2012. Wang Q, Liu J, Guo Y, Dong G, Zou W, Chen Z. 2019. Association between BDNF G196A (Val66Met) polymorphism and cognitive impairment in patients with Parkinson's disease: a meta-analysis. Braz J Med Biol Res, 52: e8443. | ||
آمار تعداد مشاهده مقاله: 17,726 تعداد دریافت فایل اصل مقاله: 770 |