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Akomolafe, Idowu, Chetty, Naven. (1401). Evaluation of Radioprotective Efficacy of Drymaria Cordata Extract on Whole-Body Radiation-Induced Hematological Damage in Mice. , 19(3), 136-144. doi: 10.22038/ijmp.2021.56512.1946
Idowu Richard Akomolafe; Naven Chetty. "Evaluation of Radioprotective Efficacy of Drymaria Cordata Extract on Whole-Body Radiation-Induced Hematological Damage in Mice". , 19, 3, 1401, 136-144. doi: 10.22038/ijmp.2021.56512.1946
Akomolafe, Idowu, Chetty, Naven. (1401). 'Evaluation of Radioprotective Efficacy of Drymaria Cordata Extract on Whole-Body Radiation-Induced Hematological Damage in Mice', , 19(3), pp. 136-144. doi: 10.22038/ijmp.2021.56512.1946
Akomolafe, Idowu, Chetty, Naven. Evaluation of Radioprotective Efficacy of Drymaria Cordata Extract on Whole-Body Radiation-Induced Hematological Damage in Mice. , 1401; 19(3): 136-144. doi: 10.22038/ijmp.2021.56512.1946

Evaluation of Radioprotective Efficacy of Drymaria Cordata Extract on Whole-Body Radiation-Induced Hematological Damage in Mice

Iranian Journal of Medical Physics
مقاله 1، دوره 19، شماره 3، مرداد و شهریور 2022، صفحه 136-144    اصل مقاله (1.37 M)
نوع مقاله: Original Paper
شناسه دیجیتال (DOI): 10.22038/ijmp.2021.56512.1946
نویسندگان
Idowu Richard Akomolafe* ؛ Naven Chetty
School of Chemistry and Physics, Discipline of Physics, University of KwaZulu-Natal, Private Bag X01, Scottsville, 3209, Pietermaritzburg, South Africa
چکیده
Introduction: Ionising radiation in diagnostic and therapeutic radiology is steadily increasing, with clear significant benefits. However, the issues of unwanted radiation exposure to patients and medical workers, which has a hugely deleterious effect, remain a challenge that requires urgent attention. Thus, this study aimed to evaluate the possible radioprotective potential of Drymaria cordata (DC) extract on mice’s hematological parameters following exposure to X-ray radiation and investigate its ability to increase the survival rate.
Material and Methods: Sixty female mice weighing 38-45g, 10-12 weeks old, were used for this study. The mice were divided into six different groups containing ten mice, sub-divided into irradiated and un-irradiated groups. The animals received 250mg/kg extract of DC by oral gavage for thirteen days in addition to feeding and water ad libitum. Mice were irradiated at the Radiotherapy and Oncology Department of Grey’s Hospital using a linear accelerator. Blood samples were collected at different time intervals for the hematology test with post-irradiation monitoring for 30 days.
Results: Exposure of mice to 4Gy and 8Gy of X-ray radiation produced significant changes in the mice’s erythrocytes, hematocrit, leukocytes and platelets in a dose and time-dependent manner compared with the control (CNT) group. The present study revealed a progressive decrease in all the hematological parameters until 30 days among the irradiated groups. However, animals treated with DC extract before irradiation and animals who received extract only exhibited a significant time-dependent increase in the studied hematological parameters compared to the animals in the CNT group. Furthermore, the pre-treatment of mice with the DC delayed the onset of mortality, thereby increasing the mice's survival rate compared with the irradiated control.
Conclusion: Our findings showed that DC is a potent natural radioprotective agent through its ability to reduce radiation-induced damage in mice’s hematopoietic system and increase the survival rate.
کلیدواژه‌ها
Radiation Protection Radiotherapy Linear Accelerator Hematology Free Radicals X؛ ray
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