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Lin, Chun-Che, Yang, Ya-Chen, Chen, Chia-Yu, Yin, Mei-Chin. (1400). Combination of s-methyl cysteine and protocatechuic acid provided greater lipid-lowering and anti-inflammatory effects in mice liver against chronic alcohol consumption. , 24(8), 1146-1152. doi: 10.22038/ijbms.2021.56705.12660
Chun-Che Lin; Ya-Chen Yang; Chia-Yu Chen; Mei-Chin Yin. "Combination of s-methyl cysteine and protocatechuic acid provided greater lipid-lowering and anti-inflammatory effects in mice liver against chronic alcohol consumption". , 24, 8, 1400, 1146-1152. doi: 10.22038/ijbms.2021.56705.12660
Lin, Chun-Che, Yang, Ya-Chen, Chen, Chia-Yu, Yin, Mei-Chin. (1400). 'Combination of s-methyl cysteine and protocatechuic acid provided greater lipid-lowering and anti-inflammatory effects in mice liver against chronic alcohol consumption', , 24(8), pp. 1146-1152. doi: 10.22038/ijbms.2021.56705.12660
Lin, Chun-Che, Yang, Ya-Chen, Chen, Chia-Yu, Yin, Mei-Chin. Combination of s-methyl cysteine and protocatechuic acid provided greater lipid-lowering and anti-inflammatory effects in mice liver against chronic alcohol consumption. , 1400; 24(8): 1146-1152. doi: 10.22038/ijbms.2021.56705.12660

Combination of s-methyl cysteine and protocatechuic acid provided greater lipid-lowering and anti-inflammatory effects in mice liver against chronic alcohol consumption

Iranian Journal of Basic Medical Sciences
مقاله 16، دوره 24، شماره 8، آبان 2021، صفحه 1146-1152    اصل مقاله (847.5 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2021.56705.12660
نویسندگان
Chun-Che Lin1؛ Ya-Chen Yang2؛ Chia-Yu Chen3؛ Mei-Chin Yin* 2، 4
1Center for Digestive Medicine, China Medical University Hospital, China Medical University, Taichung, Taiwan
2Department of Food Nutrition and Health Biotechnology, Asia University, Taichung, Taiwan
3Department of Gastroenterology, Asia University Hospital, Taichung, Taiwan
4Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan
چکیده
Objective(s): Protective effects of s-methyl cysteine (SMC) alone, protocatechuic acid (PCA) alone, and SMC plus PCA against chronic ethanol consumption induced hepatic steatosis and inflammation were investigated.  
Materials and Methods: Mice were divided into six groups: normal diet (ND) group, Lieber-DeCarli liquid diet without ethanol (LD diet) group, LD diet with ethanol (LED diet) group, SMC group (LED diet plus 0.25% SMC), PCA group (LED diet plus 0.25% PCA), and SMC+PCA group (LED diet plus 0.125% SMC + 0.125% PCA).  After 8 weeks of supplementation, blood and liver were used for analysis.  
Results: Biochemical and histological data showed that SMC plus PCA led to a greater reduction in lipid droplets in the liver than SMC or PCA treatment alone.  SMC plus PCA resulted in greater suppression in hepatic mRNA expression of peroxisome proliferator-activated receptor-gamma, sterol regulatory element-binding protein 1c, stearoyl-CoA desaturase-1, cyclooxygenase-2, and myeloperoxidase than SMC or PCA treatment alone.  SMC plus PCA led to a greater decrease in hepatic reactive oxygen species and inflammatory cytokine levels than SMC or PCA treatment alone.  
Conclusion: These novel findings suggest that the combination of SMC and PCA was a potent remedy for alcoholic liver disorders.
کلیدواژه‌ها
Ethanol Hepatic steatosis Myeloperoxidase Protocatechuic acid S؛ methyl cysteine
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