سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

عباسی, دکتر زهره, خدابنده, فرزانه, یحیوی کوچکسرایی, فاطمه, نظری, سکینه. (1400). بررسی تأثیر سوء‌مصرف استروئید آنابولیک آندروژنی بر باروری مردان: مطالعه مروری. , 24(3), 71-84. doi: 10.22038/ijogi.2021.18307
دکتر زهره عباسی; فرزانه خدابنده; فاطمه یحیوی کوچکسرایی; سکینه نظری. "بررسی تأثیر سوء‌مصرف استروئید آنابولیک آندروژنی بر باروری مردان: مطالعه مروری". , 24, 3, 1400, 71-84. doi: 10.22038/ijogi.2021.18307
عباسی, دکتر زهره, خدابنده, فرزانه, یحیوی کوچکسرایی, فاطمه, نظری, سکینه. (1400). 'بررسی تأثیر سوء‌مصرف استروئید آنابولیک آندروژنی بر باروری مردان: مطالعه مروری', , 24(3), pp. 71-84. doi: 10.22038/ijogi.2021.18307
عباسی, دکتر زهره, خدابنده, فرزانه, یحیوی کوچکسرایی, فاطمه, نظری, سکینه. بررسی تأثیر سوء‌مصرف استروئید آنابولیک آندروژنی بر باروری مردان: مطالعه مروری. , 1400; 24(3): 71-84. doi: 10.22038/ijogi.2021.18307

بررسی تأثیر سوء‌مصرف استروئید آنابولیک آندروژنی بر باروری مردان: مطالعه مروری

مجله زنان، مامایی و نازایی ایران
دوره 24، شماره 3، خرداد 1400، صفحه 71-84    اصل مقاله (654.34 K)
نوع مقاله: مروری
شناسه دیجیتال (DOI): 10.22038/ijogi.2021.18307
نویسندگان
دکتر زهره عباسی1؛ فرزانه خدابنده* 2؛ فاطمه یحیوی کوچکسرایی3؛ سکینه نظری3
1دکتری بهداشت باروری، دانشکده پزشکی، دانشگاه علوم پزشکی خراسان شمالی، بجنورد، ایران.
2مربی گروه مامایی، دانشکده پزشکی، دانشگاه علوم پزشکی خراسان شمالی، بجنورد، ایران.
3دانشجوی دکتری بهداشت باروری، کمیته تحقیقات دانشجویی، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران.
چکیده
مقدمه: علاقه جوانان به ورزش­های قدرتی سبب استفاده زیاد استروئیدهای آنابولیک (AAS) بدون توجه به عوارض طولانی­‌مدت آن شده است. از این رو، مطالعه مروری حاضر با هدف بررسی تأثیر داروهای AAS بر باروری مردان انجام شد.
روش­کار: در راستای هدف مطالعه مروری حاضر، جستجو در پایگاه­های اطلاعاتی Google Scholar، Irandoc، ISC،‌ Science Direct،‌‌Proquest ، ‌Pubmed، Scopus و Magiran با کلید واژه‌های داروهای انرژی­زا، باروری مردان، اسپرماتوژنز، استروئید آنابولیک آندروژنی و AAS بدون محدودیت سال انجام شد. از مجموع 8453 مقاله استخراج شده، پس از بررسی عنوان، چکیده و معیارهای ورود و خروج، در نهایت 33 مقاله مورد بررسی قرار گرفت.
یافته­ها: داروهای AAS عوارض طولانی مدتی بر سیستم­ باروری مردان دارند؛ به‌طوری‌که اسپرماتوژنز را از طریق 4 مکانیسم اولیه شامل اثرات مستقیم بر سلول­های جنسی، تغییر محور هیپوتالاموس، هیپوفیز و بیضه، اختلال عملکرد نعوظ یا انزال و کاهش میل جنسی مختل می­کند. همچنین با مهار بازخورد منفی در سطوح LH و FSH نیز سبب کاهش تولید تستوسترون و سرکوب اسپرماتوژنز می­گردد. اکثر عوارض پس از قطع مصرف، برگشت­پذیرند، اما مصرف طولانی­مدت در سنین باروری و مراحل تکامل بیضه سبب اختلال در آنالیز مایع منی و پارامترهای عملکردی اسپرم می­شود و امکان پاسخ به درمان جایگرین هم وجود ندارد. هنوز اطلاعات کافی برای زمان مورد نیاز جهت برگشت قدرت باروری مردان بعد از قطع مصرف گزارش نشده است.
نتیجه­گیری: مصرف بی‌رویه داروهای AAS اثرات نامطلوب درازمدتی بر سلامت باروری مردان دارد، از این رو وجود اقلام متنوع و ناشناخته دارو در بازار، حجمه تبلیغات در باشگاه‌ها و فضای مجازی و مصرف زیاد دارو بدون توجه به عوارض آن، نیازمند اقدامات مدیریتی جهت حل این معضل بهداشت جهانی و حفظ سلامت باروری مردان دارد‌، لذا آموزش به جامعه، ورزشکاران، مربیان و ارائه­دهندگان مراقبت­های بهداشتی توصیه می­شود.
کلیدواژه‌ها
باروری؛ داروهای استروئید آنابولیک آندروژنی؛ مردان
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