The bidirectional effect of prelimbic 5-hydroxytryptamine type-4 (5-HT4) receptors on ACPA-mediated aversive memory impairment in adult male Sprague-Dawley rats | ||
| Iranian Journal of Basic Medical Sciences | ||
| مقاله 3، دوره 24، شماره 6، شهریور 2021، صفحه 726-733 اصل مقاله (712.24 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22038/ijbms.2021.49501.11317 | ||
| نویسندگان | ||
| Nargol Ahmadi-Mahmoodabadi* 1، 2؛ Masoumeh Emamghoreishi3؛ Mohammad Nasehi4؛ Mohammad-Reza Zarrindast1، 4، 5، 6، 7 | ||
| 1Institute for Cognitive Science Studies, Tehran, Iran | ||
| 2Department of Basic Sciences, Campus of Shahid Bahonar, Farhangian University of Shiraz, Shiraz, Iran | ||
| 3Department of Pharmacology, School of Medicine and Department of Neuroscience, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 4Cognitive and Neuroscience Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran | ||
| 5Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran | ||
| 6Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran | ||
| 7School of Cognitive Sciences, Institute for Research in Fundamental Sciences, Tehran, Iran | ||
| چکیده | ||
| Objective(s): This study aimed at investigating the effect of serotonergic 5-HT4 receptor agonist/antagonist on memory consolidation deficit induced by ACPA (a potent, selective CB1 cannabinoid receptor agonist) in the pre-limbic (PL) cortex. Materials and Methods: We used the step-through passive avoidance test to evaluate memory consolidation of male Sprague-Dawley (SD) rats. Bilateral post-training microinjections of the drugs were done in a volume of 0.6 μl/rat into the PL area (0.3 μl per side). Results: The results showed a significant interaction between RS67333 hydrochloride (5-HT4 receptor agonist) or RS23597-190 hydrochloride (5-HT4 receptor antagonist) and ACPA on consolidation of aversive memory. RS67333 hydrochloride (0.5 μg/rat) enhanced consolidation of memory and its co-administration at the ineffective dose of 0.005 μg/rat with ineffective (0.001 μg/rat) or effective (0.1 μg/rat) doses of ACPA improved and prevented impairment of memory caused by ACPA, respectively. In other words, RS67333 had a bidirectional effect on ACPA-caused amnesia. While RS23597-190 hydrochloride had no effect on memory at the doses used (0.005, 0.01, 0.1, or 0.5 μg/rat); but its concomitant use with an effective dose of ACPA (0.1 μg/rat) potentiated amnesia. None of the drugs had an effect on locomotor activity. Conclusion: This study revealed that activation or deactivation of the 5-HT4 receptors in the PL may mediate the IA memory impairment induced by ACPA indicating a modulatory role for the 5-HT4 serotonergic receptors. | ||
| کلیدواژهها | ||
| ACPA؛ Pre-limbic cortex؛ Passive avoidance memory؛ RS23597-190؛ RS67333 | ||
| مراجع | ||
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