Erdemli, Mehmet, Erdemli, Zeynep, Gul, Mehmet, Altinoz, Eyup, Gul, Semir, Kocaman, Gulhan, Kustepe, Elif, Gozukara Bag, Harika. (1400). Ameliorative effects of crocin on the inflammation and oxidative stress-induced kidney damages by experimental periodontitis in rat. , 24(6), 825-832. doi: 10.22038/ijbms.2021.55875.12499
Mehmet Erman Erdemli; Zeynep Erdemli; Mehmet Gul; Eyup Altinoz; Semir Gul; Gulhan Kocaman; Elif Kustepe; Harika Gozde Gozukara Bag. "Ameliorative effects of crocin on the inflammation and oxidative stress-induced kidney damages by experimental periodontitis in rat". , 24, 6, 1400, 825-832. doi: 10.22038/ijbms.2021.55875.12499
Erdemli, Mehmet, Erdemli, Zeynep, Gul, Mehmet, Altinoz, Eyup, Gul, Semir, Kocaman, Gulhan, Kustepe, Elif, Gozukara Bag, Harika. (1400). 'Ameliorative effects of crocin on the inflammation and oxidative stress-induced kidney damages by experimental periodontitis in rat', , 24(6), pp. 825-832. doi: 10.22038/ijbms.2021.55875.12499
Erdemli, Mehmet, Erdemli, Zeynep, Gul, Mehmet, Altinoz, Eyup, Gul, Semir, Kocaman, Gulhan, Kustepe, Elif, Gozukara Bag, Harika. Ameliorative effects of crocin on the inflammation and oxidative stress-induced kidney damages by experimental periodontitis in rat. , 1400; 24(6): 825-832. doi: 10.22038/ijbms.2021.55875.12499

Ameliorative effects of crocin on the inflammation and oxidative stress-induced kidney damages by experimental periodontitis in rat

Iranian Journal of Basic Medical Sciences
مقاله 14، دوره 24، شماره 6، شهریور 2021، صفحه 825-832    اصل مقاله (1.03 M)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2021.55875.12499
نویسندگان
Mehmet Erman Erdemli* 1؛ Zeynep Erdemli1؛ Mehmet Gul2؛ Eyup Altinoz3؛ Semir Gul2؛ Gulhan Kocaman4؛ Elif Kustepe2؛ Harika Gozde Gozukara Bag5
1Inonu University, Faculty of Medicine, Medical Biochemistry Department, Malatya, Turkey
2Inonu University, Faculty of Medicine, Histology and Embryology Department, Malatya, Turkey
3Karabuk University, Faculty of Medicine, Medical Biochemistry Department, Karabuk, Turkey
4Karabuk University, Faculty of Dentistry, Periodontology Department, Karabuk, Turkey
5Inonu University, Faculty of Medicine, Biostatistics Department, Malatya, Turkey
چکیده
Objective(s): The present study aimed to investigate the effects of periodontitis on kidneys and the protective role of crocin in periodontitis-induced kidney damage.
Materials and Methods: Ethics committee approval was obtained and 30 Wistar rats were randomly divided into 3 groups of 10 rats: Control (C), Periodontitis (P), and Periodontitis + Crocin (P + Cr). After the treatments, rat kidney tissues were incised under anesthesia and blood samples were collected. Biochemical and histopathological analyses were conducted on the samples.
Results: Malondialdehyde (MDA), total oxidant status (TOS), and oxidative stress index (OSI) increased in P group rat kidney tissues; urea, creatinine, Tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin 1β (IL-1β) levels increased in the serum; glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and total antioxidant status (TAS) levels were reduced in rat kidney tissues, and renal histopathology deteriorated. In the P + Cr group, we observed improvements in biochemical and histopathological parameters when compared with the P group.
Conclusion: Periodontitis (P) led to deterioration in oxidative stress parameters and histopathology by increasing the oxidants in kidney tissue. P also led to inflammation in the blood of the rats. Periodontitis + Crocin (P + Cr) administration alleviated the effects of P due to powerful antioxidant anti-inflammatory properties. Cr could be employed as a protective agent in P-induced inflammation and oxidative damage.
کلیدواژه‌ها
Crocin؛ Inflammation؛ Kidney damage؛ Oxidative stress؛ Periodontitis؛ Rat
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