سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Nasrollahzadeh Sabet, Mehrdad, Movahedi asl, Masood, Kazemi Esfeh, Mahtab, Nasrabadi, Navid, Shakarami, Maryam, Alani, Behrang, Alimolaie, Asma, Azhdari, Sara, Cheraghi, Ebrahim. (1400). Mesenchymal stem cells as professional actors in gastrointestinal cancer therapy: From Naïve to genetically modified. , 24(5), 561-576. doi: 10.22038/ijbms.2021.54735.12277
Mehrdad Nasrollahzadeh Sabet; Masood Movahedi asl; Mahtab Kazemi Esfeh; Navid Nasrabadi; Maryam Shakarami; Behrang Alani; Asma Alimolaie; Sara Azhdari; Ebrahim Cheraghi. "Mesenchymal stem cells as professional actors in gastrointestinal cancer therapy: From Naïve to genetically modified". , 24, 5, 1400, 561-576. doi: 10.22038/ijbms.2021.54735.12277
Nasrollahzadeh Sabet, Mehrdad, Movahedi asl, Masood, Kazemi Esfeh, Mahtab, Nasrabadi, Navid, Shakarami, Maryam, Alani, Behrang, Alimolaie, Asma, Azhdari, Sara, Cheraghi, Ebrahim. (1400). 'Mesenchymal stem cells as professional actors in gastrointestinal cancer therapy: From Naïve to genetically modified', , 24(5), pp. 561-576. doi: 10.22038/ijbms.2021.54735.12277
Nasrollahzadeh Sabet, Mehrdad, Movahedi asl, Masood, Kazemi Esfeh, Mahtab, Nasrabadi, Navid, Shakarami, Maryam, Alani, Behrang, Alimolaie, Asma, Azhdari, Sara, Cheraghi, Ebrahim. Mesenchymal stem cells as professional actors in gastrointestinal cancer therapy: From Naïve to genetically modified. , 1400; 24(5): 561-576. doi: 10.22038/ijbms.2021.54735.12277

Mesenchymal stem cells as professional actors in gastrointestinal cancer therapy: From Naïve to genetically modified

Iranian Journal of Basic Medical Sciences
مقاله 2، دوره 24، شماره 5، مرداد 2021، صفحه 561-576    اصل مقاله (764.72 K)
نوع مقاله: Review Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2021.54735.12277
نویسندگان
Mehrdad Nasrollahzadeh Sabet1؛ Masood Movahedi asl2؛ Mahtab Kazemi Esfeh3؛ Navid Nasrabadi4؛ Maryam Shakarami5؛ Behrang Alani6؛ Asma Alimolaie7؛ Sara Azhdari8؛ Ebrahim Cheraghi* 9
1School of Medicine, AJA University of Medical Science, Tehran, Iran
2Non-Communicable Diseases Research Center, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran
3Department of Biology, School of Science, Shiraz University, Shiraz, Iran
4School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5Department of Cellular & Molecular Biology, Isfahan University, Isfahan, Iran
6Department of Applied Cell Sciences, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran
7Department of Biology, Faculty of Science, Shahid Bahonar University of Kerman, Kerman, Iran
8Department of Anatomy and Embryology, School of Medicine, Bam University of Medical Sciences, Bam, Iran
9Department of Biology, Faculty of Sciences, University of Qom, Qom, Iran
چکیده
Considering the high incidence and mortality rate of gastrointestinal cancers (GIs) worldwide and partial success of the current available GI cancer treatments, there is a necessity to discover more effective approaches in cancer therapy. The failure in conventional therapies seems to be related to the resistance of cancer cells to chemotherapy, inability to target tumor cells especially in metastatic cancers, deficient drug concentrations in tumor sites, and unfavorable effects on pivotal non-malignant bodily tissues following systemic administration. In this context, we need an appropriate carrier for the delivery of therapeutic agents specifically to the GI cancer site. Mesenchymal stem cells (MSCs), a prominent cell-based strategy for cancer treatment, overcome various cancer therapy limitations and could be used as vehicles to deliver many anticancer agents such as therapeutic genes (DNA or interference RNA), oncolytic viruses, and chemotherapeutic or nanoparticle drugs. Moreover, secreted molecules of unmodified MSCs lead to deregulation of several proteins and different signaling pathways eradicating cancer cells. In the present review, at first, we overview the characteristics and utility of MSCs in cancer therapy, secondly, we discuss the application of naïve MSCs and utilization of MSCs in the delivery of therapeutic agents in GI cancer therapy and, finally, more information about harnessing of genetically modified MSCs in GI cancer treatment will be presented.
کلیدواژه‌ها
Cancer therapy؛ Gastrointestinal cancers؛ Gene therapy؛ Genetic engineering؛ Mesenchymal stem cells
مراجع
1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: Cancer J Clin 2018; 68:394-424.
2. Poustchi F, Amani H, Ahmadian Z, Niknezhad SV, Mehrabi S, Santos HA, et al. Combination therapy of killing diseases by injectable hydrogels: From concept to medical applications. Adv Healthc Mater 2020:2001571.
3. Arnold M, Abnet CC, Neale RE, Vignat J, Giovannucci EL, McGlynn KA, et al. Global burden of 5 major types of gastrointestinal cancer. Gastroenterology 2020.
4. Mokhtari RB, Homayouni TS, Baluch N, Morgatskaya E, Kumar S, Das B, et al. Combination therapy in combating cancer. Oncotarget 2017; 8:38022.
5. Senapati S, Mahanta AK, Kumar S, Maiti P. Controlled drug delivery vehicles for cancer treatment and their performance. SIGNAL TRANSDUCT TAR 2018; 3:1-19.
6. Wu H-C, Chang D-K, Huang C-T. Targeted therapy for cancer. J Cancer Mol 2006; 2:57-66.
7. Lee YT, Tan YJ, Oon CE. Molecular targeted therapy: treating cancer with specificity. Eur J Pharmacol 2018; 834:188-196.
8. Wirth T, Ylä-Herttuala S. Gene Therapy Used in Cancer Treatment. Biomedicines 2014; 2:149-162.
9. Cross D, Burmester JK. Gene therapy for cancer treatment: past, present and future. Clin Med Res 2006; 4:218-227.
10. Li T, Kang G, Wang T, Huang H. Tumor angiogenesis and anti-angiogenic gene therapy for cancer. Oncol Lett 2018; 16:687-702.
11. Sayed-Ahmed MZ, Makeen HA, Elsherbini MM, Syed NK, Shoeib SM. Oncolytic Viruses: A gene Therapy for Treatment of Cancer in Companion Animals. Health Sci J 2018; 12:1-9.
12. Scheller EL, Krebsbach PH. Gene therapy: design and prospects for craniofacial regeneration. J Dent Res 2009; 88:585-596.
13. Schatzlein A. Non-viral vectors in cancer gene therapy: principles and progress. Anti-cancer drugs 2001; 12:275-304.
14. Li Z, Fan D, Xiong D. Mesenchymal stem cells as delivery vectors for anti-tumor therapy. Stem Cell Investig 2015; 2.
15. Rawat S, Gupta S, Mohanty S. Mesenchymal stem cells modulate the immune system in developing therapeutic interventions.  Immune Response Activation and Immunomodulation: IntechOpen; 2019.
16. Mosallaei M, Simonian M, Ehtesham N, Karimzadeh MR, Vatandoost N, Negahdari B, et al. Genetically engineered mesenchymal stem cells: targeted delivery of immunomodulatory agents for tumor eradication. Cancer Gene Ther 2020:1-15.
17. Javan MR, Khosrojerdi A, Moazzeni SM. New insights into implementation of mesenchymal stem cells in cancer therapy: Prospects for anti-angiogenesis treatment. Frontiers in oncology 2019; 9:840.
18. Rajabzadeh N, Fathi E, Farahzadi R. Stem cell-based regenerative medicine. Stem Cell Investig 2019; 6:19-19.
19. Berebichez-Fridman R, Montero-Olvera PR. Sources and clinical applications of mesenchymal stem cells: state-of-the-art review. Sultan Qaboos Univ Med J 2018; 18:e264.
20. Izadpanah R, Trygg C, Patel B, Kriedt C, Dufour J, Gimble JM, et al. Biologic properties of mesenchymal stem cells derived from bone marrow and adipose tissue. J Cell Biochem 2006; 99:1285-1297.
21. Najar M, Raicevic G, Kazan HF, De Bruyn C, Bron D, Toungouz M, et al. Immune-related antigens, surface molecules and regulatory factors in human-derived mesenchymal stromal cells: the expression and impact of inflammatory priming. Stem Cell Rev Rep 2012; 8:1188-1198.
22. Machado CdV, Telles PDdS, Nascimento ILO. Immunological characteristics of mesenchymal stem cells. Rev Bras Hematol Hemoter 2013; 35:62-67.
23. Dai L-J, Moniri MR, Zeng Z-R, Zhou JX, Rayat J, Warnock GL. Potential implications of mesenchymal stem cells in cancer therapy. Cancer Lett 2011; 305:8-20.
24. Rustad KC, Gurtner GC. Mesenchymal stem cells home to sites of injury and inflammation. Adv Wound Care 2012; 1:147-152.
25. Ghaffari-Nazari H. The known molecules involved in MSC homing and migration. J Stem Cell Res Med 2018; 3:1-4.
26. Lüttichau IV, Notohamiprodjo M, Wechselberger A, Peters C, Henger A, Seliger C, et al. Human adult CD34− progenitor cells functionally express the chemokine receptors CCR1, CCR4, CCR7, CXCR5, and CCR10 but not CXCR4. Stem Cells Dev 2005; 14:329-336.
27. Cojoc M, Peitzsch C, Trautmann F, Polishchuk L, Telegeev GD, Dubrovska A. Emerging targets in cancer management: role of the CXCL12/CXCR4 axis. OncoTargets Ther 2013; 6:1347.
28. Son BR, Marquez-Curtis LA, Kucia M, Wysoczynski M, Turner AR, Ratajczak J, et al. Migration of bone marrow and cord blood mesenchymal stem cells in vitro is regulated by stromal-derived factor-1-CXCR4 and hepatocyte growth factor-c-met axes and involves matrix metalloproteinases. Stem cells 2006; 24:1254-1264.
29. Hu Y-L, Fu Y-H, Tabata Y, Gao J-Q. Mesenchymal stem cells: a promising targeted-delivery vehicle in cancer gene therapy. J Control Release 2010; 147:154-162.
30. Sage EK, Thakrar RM, Janes SM. Genetically modified mesenchymal stromal cells in cancer therapy. Cytotherapy 2016; 18:1435-1445.
31. Christodoulou I, Goulielmaki M, Devetzi M, Panagiotidis M, Koliakos G, Zoumpourlis V. Mesenchymal stem cells in preclinical cancer cytotherapy: a systematic review. Stem Cell Res Ther 2018; 9:336.
32. He N, Kong Y, Lei X, Liu Y, Wang J, Xu C, et al. MSCs inhibit tumor progression and enhance radiosensitivity of breast cancer cells by down-regulating Stat3 signaling pathway. Cell Death Dis 2018; 9:1-14.
33. Nakamizo A, Marini F, Amano T, Khan A, Studeny M, Gumin J, et al. Human bone marrow–derived mesenchymal stem cells in the treatment of gliomas. Cancer Res 2005; 65:3307-3318.
34. Akimoto K, Kimura K, Nagano M, Takano S, To’a Salazar G, Yamashita T, et al. Umbilical cord blood-derived mesenchymal stem cells inhibit, but adipose tissue-derived mesenchymal stem cells promote, glioblastoma multiforme proliferation. Stem Cells Dev 2013; 22:1370-1386.
35. Javan MR, Khosrojerdi A, Moazzeni SM. New insights into implementation of mesenchymal stem cells in cancer therapy: prospects for anti-angiogenesis treatment. Front Oncol 2019; 9.
36. Wong RS. Mesenchymal stem cells: angels or demons? J Biomed Biotechnol 2011; 2011:459510.
37. Paiboon N, Kamprom W, Manochantr S, Tantrawatpan C, Tantikanlayaporn D, Roytrakul S, et al. Gestational tissue-derived human mesenchymal stem cells use distinct combinations of bioactive molecules to suppress the proliferation of human hepatoblastoma and colorectal cancer cells. Stem Cells Int 2019; 2019.
38. Chen H-L, Li J-J, Jiang F, Shi W-J, Chang G-Y. MicroRNA-4461 derived from bone marrow mesenchymal stem cell exosomes inhibits tumorigenesis by downregulating COPB2 expression in colorectal cancer. Biosci Biotechnol Biochem 2020; 84:338-346.
39. François S, Usunier B, Forgue-Lafitte ME, L’Homme B, Benderitter M, Douay L, et al. Mesenchymal stem cell administration attenuates colon cancer progression by modulating the immune component within the colorectal tumor microenvironment. Stem Cells Transl Med 2019; 8:285-300.
40. Chen Z, He X, He X, Chen X, Lin X, Zou Y, et al. Bone marrow mesenchymal stem cells ameliorate colitis-associated tumorigenesis in mice. Biochem Biophys Res Commun 2014; 450:1402-1408.
41. Tang R-j, Shen S-n, Zhao X-y, Nie Y-z, Xu Y-j, Ren J, et al. Mesenchymal stem cells-regulated Treg cells suppress colitis-associated colorectal cancer. Stem Cell Res Ther 2015; 6:71.
42. Hou L, Wang X, Zhou Y, Ma H, Wang Z, He J, et al. Inhibitory effect and mechanism of mesenchymal stem cells on liver cancer cells. Tumor Biol 2014; 35:1239-1250.
43. Qiao L, Xu Z, Zhao T, Zhao Z, Shi M, Zhao RC, et al. Suppression of tumorigenesis by human mesenchymal stem cells in a hepatoma model. Cell Res 2008; 18:500-507.
44. Zhao W, Ren G, Zhang L, Zhang Z, Liu J, Kuang P, et al. Efficacy of mesenchymal stem cells derived from human adipose tissue in inhibition of hepatocellular carcinoma cells in vitro. Cancer Biother Radiopharm 2012; 27:606-613.
45. Serhal R, Saliba N, Hilal G, Moussa M, Hassan GS, El Atat O, et al. Effect of adipose-derived mesenchymal stem cells on hepatocellular carcinoma: In vitro inhibition of carcinogenesis. World J Gastroenterol 2019; 25:567.
46. Byun CS, Hwang S, Woo S-H, Kim MY, Lee JS, Lee JI, et al. Adipose tissue-derived mesenchymal stem cells suppress growth of Huh7 hepatocellular carcinoma cells via interferon (IFN)-β-mediated JAK/STAT1 pathway in vitro. Int J Med Sci 2020; 17:609.
47. Ma B, Jiang H, Jia J, Di L, Song G, Yu J, et al. Murine bone marrow stromal cells pulsed with homologous tumor-derived exosomes inhibit proliferation of liver cancer cells. Clin Transl Oncol 2012; 14:764-773.
48. Li GC, Ye QH, Xue YH, Sun HJ, Zhou HJ, Ren N, et al. Human mesenchymal stem cells inhibit metastasis of a hepatocellular carcinoma model using the MHCC97-H cell line. Cancer Sci 2010; 101:2546-2553.
49. Ko S-F, Yip H-K, Zhen Y-Y, Lee C-C, Lee C-C, Huang C-C, et al. Adipose-derived mesenchymal stem cell exosomes suppress hepatocellular carcinoma growth in a rat model: apparent diffusion coefficient, natural killer T-cell responses, and histopathological features. Stem Cells Int 2015; 2015.
50. Wu L, Tang Q, Yin X, Tang M, Xin J, Pan Q, et al. The therapeutic potential of adipose tissue-derived mesenchymal stem cells to enhance radiotherapy effects on hepatocellular carcinoma. Front. Cell Dev. Biol 2019; 7:267.
51. Hajighasemlou S, Nikbakht M, Pakzad S, Muhammadnejad S, Gharibzadeh S, Mirmoghtadaei M, et al. Sorafenib and Mesenchymal Stem Cell Therapy: A Promising Approach for Treatment of HCC. Evid Based Complement Alternat Med 2020; 2020.
52. Seyhoun I, Hajighasemlou S, Muhammadnejad S, Ai J, Nikbakht M, Alizadeh Aa, et al. Combination therapy of sorafenib with mesenchymal stem cells as a novel cancer treatment regimen in xenograft models of hepatocellular carcinoma. J Cell Physiol 2019; 234:9495-9503.
53. Ding Y, Cao F, Sun H, Wang Y, Liu S, Wu Y, et al. Exosomes derived from human umbilical cord mesenchymal stromal cells deliver exogenous miR-145-5p to inhibit pancreatic ductal adenocarcinoma progression. Cancer Lett 2019; 442:351-361.
54. Cousin B, Ravet E, Poglio S, De Toni F, Bertuzzi M, Lulka H, et al. Adult stromal cells derived from human adipose tissue provoke pancreatic cancer cell death both in vitro and in vivo. PLoS One 2009; 4:e6278.
55. Doi C, Maurya DK, Pyle MM, Troyer D, Tamura M. Cytotherapy with naive rat umbilical cord matrix stem cells significantly attenuates growth of murine pancreatic cancer cells and increases survival in syngeneic mice. Cytotherapy 2010; 12:408-417.
56. Liu J, Han G, Liu H, Qin C. Suppression of cholangiocarcinoma cell growth by human umbilical cord mesenchymal stem cells: a possible role of Wnt and Akt signaling. PLoS One 2013; 8:e62844.
57. Zhao J, Zhao X, Yang Y, Zhang Y, Zhao S. Effect of umbilical cord mesenchymal stem cells on biological characteristics of esophageal cancer EC1 cells. Zhonghua zhong liu za zhi [Chinese journal of oncology] 2019; 41:97-101.
58. Wang Y, Fan H, Zhou B, Ju Z, Yu L, Guo L, et al. Fusion of human umbilical cord mesenchymal stem cells with esophageal carcinoma cells inhibits the tumorigenicity of esophageal carcinoma cells. Int J Oncol Res 2012; 40:370-377.
59. Zurmukhtashvili M, Machavariani A, Dugashvili G, Grdzelidze T, Gogilashvili K, Menabde G, et al. Mesenchymal stem cell transplantation attenuates growth of chemotherapy treated oral squamous cell carcinoma in an animal model. J Oral Pathol Med 2020.
60. Ji X, Zhang Z, Han Y, Song J, Xu X, Jin J, et al. Mesenchymal stem cells derived from normal gingival tissue inhibit the proliferation of oral cancer cells in vitro and in vivo. Int J Oncol 2016; 49:2011-2022.
61. Rosenberger L, Ezquer M, Lillo-Vera F, Pedraza PL, Ortúzar MI, González PL, et al. Stem cell exosomes inhibit angiogenesis and tumor growth of oral squamous cell carcinoma. Sci Rep 2019; 9:1-12.
62. Liu Y, Zhao J, Jiang J, Chen F, Fang X. Doxorubicin delivered using nanoparticles camouflaged with mesenchymal stem cell membranes to treat colon cancer. Int J Nanomed 2020; 15:2873.
63. Coccè V, Farronato D, Brini AT, Masia C, Giannì AB, Piovani G, et al. Drug loaded gingival mesenchymal stromal cells (GinPa-MSCs) inhibit in vitro proliferation of oral squamous cell carcinoma. Sci Rep 2017; 7:1-8.
64. Brini AT, Coccè V, Ferreira LMJ, Giannasi C, Cossellu G, Giannì AB, et al. Cell-mediated drug delivery by gingival interdental papilla mesenchymal stromal cells (GinPa-MSCs) loaded with paclitaxel. Expert Opin Drug Deliv  2016; 13:789-798.
65. Coccè V, Franzè S, Brini AT, Giannì AB, Pascucci L, Ciusani E, et al. In vitro anticancer activity of extracellular vesicles (EVs) secreted by gingival mesenchymal stromal cells primed with paclitaxel. Pharmaceutics 2019; 11:61.
66. Pascucci L, Coccè V, Bonomi A, Ami D, Ceccarelli P, Ciusani E, et al. Paclitaxel is incorporated by mesenchymal stromal cells and released in exosomes that inhibit in vitro tumor growth: a new approach for drug delivery. J. Control. Release 2014; 192:262-270.
67. Cocce V, Balducci L, L Falchetti M, Pascucci L, Ciusani E, T Brini A, et al. Fluorescent immortalized human adipose derived stromal cells (hASCs-TS/GFP+) for studying cell drug delivery mediated by microvesicles. Anti-Cancer Agents Med. Chem 2017; 17:1578-1585.
68. Bonomi A, Silini A, Vertua E, Signoroni PB, Coccè V, Cavicchini L, et al. Human amniotic mesenchymal stromal cells (hAMSCs) as potential vehicles for drug delivery in cancer therapy: an in vitro study. Stem Cell Res Ther 2015; 6:1-10.
69. Bonomi A, Sordi V, Dugnani E, Ceserani V, Dossena M, Coccè V, et al. Gemcitabine-releasing mesenchymal stromal cells inhibit in vitro proliferation of human pancreatic carcinoma cells. Cytotherapy 2015; 17:1687-1695.
70. Yoon A-R, Hong J, Li Y, Shin HC, Lee H, Kim HS, et al. Mesenchymal stem cell–mediated delivery of an oncolytic adenovirus enhances antitumor efficacy in hepatocellular carcinoma. Cancer Res 2019; 79:4503-4514.
71. Yuan X, Zhang Q, Li Z, Zhang X, Bao S, Fan D, et al. Mesenchymal stem cells deliver and release conditionally replicative adenovirus depending on hepatic differentiation to eliminate hepatocellular carcinoma cells specifically. Cancer Lett 2016; 381:85-95.
72. Msaouel P, Iankov ID, Allen C, Morris JC, Von Messling V, Cattaneo R, et al. Engineered measles virus as a novel oncolytic therapy against prostate cancer. Prostate 2009; 69:82-91.
73. Msaouel P, D Iankov I, Dispenzieri A, Galanis E. Attenuated oncolytic measles virus strains as cancer therapeutics. Curr Pharm Biotechnol 2012; 13:1732-1741.
74. Ong H-T, Federspiel MJ, Guo CM, Ooi LL, Russell SJ, Peng K-W, et al. Systemically delivered measles virus-infected mesenchymal stem cells can evade host immunity to inhibit liver cancer growth. J Hepatol 2013; 59:999-1006.
75. Kaczorowski A, Hammer K, Liu L, Villhauer S, Nwaeburu C, Fan P, et al. Delivery of improved oncolytic adenoviruses by mesenchymal stromal cells for elimination of tumorigenic pancreatic cancer cells. Oncotarget 2016; 7:9046.
76. Moradian Tehrani R, Verdi J, Noureddini M, Salehi R, Salarinia R, Mosalaei M, et al. Mesenchymal stem cells: A new platform for targeting suicide genes in cancer. J Cell Physiol 2018; 233:3831-3845.
77. Luetzkendorf J, Mueller LP, Mueller T, Caysa H, Nerger K, Schmoll HJ. Growth inhibition of colorectal carcinoma by lentiviral TRAIL-transgenic human mesenchymal stem cells requires their substantial intratumoral presence. J Cell Mol Med 2010; 14:2292-2304.
78. Griffith TS, Stokes B, Kucaba TA, Earel JK, Jr., VanOosten RL, Brincks EL, et al. TRAIL gene therapy: from preclinical development to clinical application. Curr Gene Ther 2009; 9:9-19.
79. Ashkenazi A, Pai RC, Fong S, Leung S, Lawrence DA, Marsters SA, et al. Safety and antitumor activity of recombinant soluble Apo2 ligand. J Clin Investig 1999; 104:155-162.
80. Grisendi G, Bussolari R, Cafarelli L, Petak I, Rasini V, Veronesi E, et al. Adipose-derived mesenchymal stem cells as stable source of tumor necrosis factor–related apoptosis-inducing ligand delivery for cancer therapy. Cancer Res 2010; 70:3718-3729.
81. Yu R, Deedigan L, Albarenque S, Mohr A, Zwacka R. Delivery of sTRAIL variants by MSCs in combination with cytotoxic drug treatment leads to p53-independent enhanced antitumor effects. Cell Death Dis 2013; 4:e503-e503.
82. Yuan Z, Kolluri KK, Sage EK, Gowers KH, Janes SM. Mesenchymal stromal cell delivery of full-length tumor necrosis factor–related apoptosis-inducing ligand is superior to soluble type for cancer therapy. Cytotherapy 2015; 17:885-896.
83. Wu L, Yang L. The function and mechanism of HMGB1 in lung cancer and its potential therapeutic implications. Oncol Lett 2018; 15:6799-6805.
84. Tang D, Kang R, Zeh HJ, 3rd, Lotze MT. High-mobility group box 1 and cancer. Biochim Biophys Acta 2010; 1799:131-140.
85. Taguchi A, Blood DC, del Toro G, Canet A, Lee DC, Qu W, et al. Blockade of RAGE–amphoterin signalling suppresses tumour growth and metastases. Nature 2000; 405:354-360.
86. Yang H, Ochani M, Li J, Qiang X, Tanovic M, Harris HE, et al. Reversing established sepsis with antagonists of endogenous high-mobility group box 1. Proc Natl Acad Sci 2004; 101:296-301.
87. Kikuchi H, Yagi H, Hasegawa H, Ishii Y, Okabayashi K, Tsuruta M, et al. Therapeutic potential of transgenic mesenchymal stem cells engineered to mediate anti–high mobility group box 1 activity: targeting of colon cancer. J Surg Res 2014; 190:134-143.
88. Harati MD, Amiri F, Jaleh F, Mehdipour A, Harati MD, Molaee S, et al. Targeting delivery of lipocalin 2-engineered mesenchymal stem cells to colon cancer in order to inhibit liver metastasis in nude mice. Tumour Biol 2015; 36:6011-6018.
89. Becerra SP, Notario V. The effects of PEDF on cancer biology: mechanisms of action and therapeutic potential. Nat Rev Cancer 2013; 13:258-271.
90. Belkacemi L, Zhang SX. Anti-tumor effects of pigment epithelium-derived factor (PEDF): implication for cancer therapy. A mini-review. J Exp Clin Cancer Res: CR 2016; 35:4-4.
91. Fernández-Barral A, Orgaz JL, Baquero P, Ali Z, Moreno A, Tiana M, et al. Regulatory and functional connection of microphthalmia-associated transcription factor and anti-metastatic pigment epithelium derived factor in melanoma. Neoplasia 2014; 16:529-542.
92. Yang L, Zhang Y, Cheng L, Yue D, Ma J, Zhao D, et al. Mesenchymal stem cells engineered to secrete pigment epithelium-derived factor inhibit tumor metastasis and the formation of malignant ascites in a murine colorectal peritoneal carcinomatosis model. Hum Gene Ther 2016; 27:267-277.
93. Xu Y, Shen L, Li F, Yang J, Wan X, Ouyang M. microRNA-16-5p-containing exosomes derived from bone marrow-derived mesenchymal stem cells inhibit proliferation, migration, and invasion, while promoting apoptosis of colorectal cancer cells by downregulating ITGA2. J Cell Physiol 2019; 234:21380-21394.
94. Li T, Wan Y, Su Z, Li J, Han M, Zhou C. Mesenchymal stem cell-derived exosomal microRNA-3940-5p inhibits colorectal cancer metastasis by targeting integrin α6. Dig Dis Sci 2020:1-12.
95. Knoop K, Schwenk N, Schmohl K, Müller A, Zach C, Cyran C, et al. Mesenchymal stem cell–mediated, tumor stroma–targeted radioiodine therapy of metastatic colon cancer using the sodium iodide symporter as theranostic gene. J Nucl Med 2015; 56:600-606.
96. Kalimuthu S, Zhu L, Oh JM, Lee HW, Gangadaran P, Rajendran RL, et al. Regulated mesenchymal stem cells mediated colon cancer therapy assessed by reporter gene based optical imaging. Int J Mol Sci 2018; 19:1002.
97. Yu Y, Wang Y-y, Wang Y-q, Wang X, Liu Y-Y, Wang J-T, et al. Antiangiogenic therapy using endostatin increases the number of ALDH+ lung cancer stem cells by generating intratumor hypoxia. Sci Rep 2016; 6:34239.
98. Dkhissi F, Lu H, Soria C, Opolon P, Griscelli F, Liu H, et al. Endostatin exhibits a direct antitumor effect in addition to its antiangiogenic activity in colon cancer cells. Hum Gene Ther 2003; 14:997-1008.
99. Zhang D, Zheng L, Shi H, Chen X, Wan Y, Zhang H, et al. Suppression of peritoneal tumorigenesis by placenta-derived mesenchymal stem cells expressing endostatin on colorectal cancer. Int J Med Sci 2014; 11:870.
100. Hombach AA, Geumann U, Günther C, Hermann FG, Abken H. IL7-IL12 Engineered mesenchymal stem cells (MSCs) improve a CAR T cell attack against colorectal cancer cells. Cells 2020; 9:873.
101. Chen X-c, Wang R, Zhao X, Wei Y-q, Hu M, Wang Y-s, et al. Prophylaxis against carcinogenesis in three kinds of unestablished tumor models via IL12-gene-engineered MSCs. Carcinogenesis 2006; 27:2434-2441.
102. Li Z, Ye Z, Zhang X, Zhang Q, Fan D, Zhang Y, et al. E1A-engineered human umbilical cord mesenchymal stem cells as carriers and amplifiers for adenovirus suppress hepatocarcinoma in mice. Oncotarget 2016; 7:51815.
103. Wang H, Wang J, Shi X, Ding Y. Genetically engineered bone marrow-derived mesenchymal stem cells co-expressing IFN-γ and IL-10 inhibit hepatocellular carcinoma by modulating MAPK pathway. J BUON 2017; 22:1517-1524.
104. Xie C, Xie D, Lin B, Zhang G, Wang P, Peng L, et al. Interferon-β gene-modified human bone marrow mesenchymal stem cells attenuate hepatocellular carcinoma through inhibiting AKT/FOXO3a pathway. Br J Cancer 2013; 109:1198-1205.
105. Floros T, Tarhini AA. Anticancer cytokines: biology and clinical effects of interferon-α2, interleukin (IL)-2, IL-15, IL-21, and IL-12. Semin Oncol 2015; 42:539-548.
106. Llovet JM, Sala M, Castells L, Suarez Y, Vilana R, Bianchi L, et al. Randomized controlled trial of interferon treatment for advanced hepatocellular carcinoma. Hepatology 2000; 31:54-58.
107. Su Y, Cheng R, Zhang J, Qian J, Diao C, Ran J, et al. Interferon-α2b gene-modified human bone marrow mesenchymal stem cells inhibit hepatocellular carcinoma by reducing the Notch1 levels. Life Sci 2015; 143:18-26.
108. Massagué J. TGFbeta in Cancer. Cell 2008; 134:215-230.
109. Nagaraj NS, Datta PK. Targeting the transforming growth factor-beta signaling pathway in human cancer. Expert Opin Investig Drugs 2010; 19:77-91.
110. Li T, Zhao S, Song B, Wei Z, Lu G, Zhou J, et al. Effects of transforming growth factor β-1 infected human bone marrow mesenchymal stem cells on high-and low-metastatic potential hepatocellular carcinoma. Eur J Med Res 2015; 20:1-11.
111. Li R, Yanjiao G, Wubin H, Yue W, Jianhua H, Huachuan Z, et al. Secreted GRP78 activates EGFR-SRC-STAT3 signaling and confers the resistance to sorafeinib in HCC cells. Oncotarget 2017; 8:19354.
112. Chiou J-F, Tai C-J, Huang M-T, Wei P-L, Wang Y-H, An J, et al. Glucose-regulated protein 78 is a novel contributor to acquisition of resistance to sorafenib in hepatocellular carcinoma. Ann Surg Oncol 2010; 17:603-612.
113. Li H, Yang C, Shi Y, Zhao L. Exosomes derived from siRNA against GRP78 modified bone-marrow-derived mesenchymal stem cells suppress Sorafenib resistance in hepatocellular carcinoma. J. Nanobiotechnology 2018; 16:1-13.
114. Lou G, Chen L, Xia C, Wang W, Qi J, Li A, et al. MiR-199a-modified exosomes from adipose tissue-derived mesenchymal stem cells improve hepatocellular carcinoma chemosensitivity through mTOR pathway. J Exp Clin Cancer Res 2020; 39:4.
115. Lou G, Song X, Yang F, Wu S, Wang J, Chen Z, et al. Exosomes derived from miR-122-modified adipose tissue-derived MSCs increase chemosensitivity of hepatocellular carcinoma. J Hematol Oncol 2015; 8:1-11.
116. Niu J, Wang Y, Wang J, Liu B, Hu X. Delivery of sFIT-1 engineered MSCs in combination with a continuous low-dose doxorubicin treatment prevents growth of liver cancer. Aging (Albany NY) 2016; 8:3520.
117. Gao Y, Yao A, Zhang W, Lu S, Yu Y, Deng L, et al. Human mesenchymal stem cells overexpressing pigment epithelium-derived factor inhibit hepatocellular carcinoma in nude mice. Oncogene 2010; 29:2784-2794.
118. Müller AM, Schmohl KA, Knoop K, Schug C, Urnauer S, Hagenhoff A, et al. Hypoxia-targeted 131I therapy of hepatocellular cancer after systemic mesenchymal stem cell-mediated sodium iodide symporter gene delivery. Oncotarget 2016; 7:54795.
119. Wu N, Zhang Y-L, Wang H-T, Li D-W, Dai H-J, Zhang Q-Q, et al. Overexpression of hepatocyte nuclear factor 4α in human mesenchymal stem cells suppresses hepatocellular carcinoma development through Wnt/β-catenin signaling pathway downregulation. Cancer Biol Ther 2016; 17:558-565.
120. Niess H, Bao Q, Conrad C, Zischek C, Notohamiprodjo M, Schwab F, et al. Selective targeting of genetically engineered mesenchymal stem cells to tumor stroma microenvironments using tissue-specific suicide gene expression suppresses growth of hepatocellular carcinoma. Ann Surg 2011; 254:767-775.
121. Deng Q, Zhang Z, Feng X, Li T, Liu N, Lai J, et al. TRAIL-secreting mesenchymal stem cells promote apoptosis in heat-shock-treated liver cancer cells and inhibit tumor growth in nude mice. Gene Ther 2014; 21:317-327.
122. Sun X-Y, Nong J, Qin K, Lu H, Moniri MR, Dai L-J, et al. MSCTRAIL-mediated HepG2 cell death in direct and indirect co-cultures. Anticancer Res 2011; 31:3705-3712.
123. Los M, Panigrahi S, Rashedi I, Mandal S, Stetefeld J, Essmann F, et al. Apoptin, a tumor-selective killer. Biochim Biophys Acta Mol Cell Res 2009; 1793:1335-1342.
124. Malla WA, Arora R, Khan RIN, Mahajan S, Tiwari AK. Apoptin as a tumor-specific therapeutic agent: current perspective on mechanism of action and delivery systems. Front Cell Dev Biol 2020; 8:524.
125. Zhang J, Hou L, Wu X, Zhao D, Wang Z, Hu H, et al. Inhibitory effect of genetically engineered mesenchymal stem cells with Apoptin on hepatoma cells in vitro and in vivo. Mol Cell Biochem 2016; 416:193-203.
126. Mohr A, Albarenque SM, Deedigan L, Yu R, Reidy M, Fulda S, et al. Targeting of XIAP combined with systemic mesenchymal stem cell-mediated delivery of sTRAIL ligand inhibits metastatic growth of pancreatic carcinoma cells. Stem cells 2010; 28:2109-2120.
127. Han J, Hwang HS, Na K. TRAIL-secreting human mesenchymal stem cells engineered by a non-viral vector and photochemical internalization for pancreatic cancer gene therapy. Biomaterials 2018; 182:259-268.
128. Spano C, Grisendi G, Golinelli G, Rossignoli F, Prapa M, Bestagno M, et al. Soluble TRAIL armed human MSC as gene therapy for pancreatic cancer. Sci Rep 2019; 9:1-14.
129. Shang S, Wang J, Chen S, Tian R, Zeng H, Wang L, et al. Exosomal miRNA-1231 derived from bone marrow mesenchymal stem cells inhibits the activity of pancreatic cancer. Cancer Med 2019; 8:7728-7740.
130. Wu D-M, Wen X, Han X-R, Wang S, Wang Y-J, Shen M, et al. Bone marrow mesenchymal stem cell-derived exosomal microRNA-126-3p inhibits pancreatic cancer development by targeting ADAM9. Mol Ther Nucleic Acids 2019; 16:229-245.
131. Xu Q, Liu X, Cai Y, Yu Y, Chen W. RNAi-mediated ADAM9 gene silencing inhibits metastasis of adenoid cystic carcinoma cells. Tumor Biol 2010; 31:217-224.
132. Conrad C, Hüsemann Y, Niess H, Von Luettichau I, Huss R, Bauer C, et al. Linking transgene expression of engineered mesenchymal stem cells and angiopoietin-1–induced differentiation to target cancer angiogenesis. Ann Surg 2011; 253:566-571.
133. Zischek C, Niess H, Ischenko I, Conrad C, Huss R, Jauch K-W, et al. Targeting tumor stroma using engineered mesenchymal stem cells reduces the growth of pancreatic carcinoma. Ann Surg 2009; 250:747-753.
134. Kidd S, Caldwell L, Dietrich M, Samudio I, Spaeth EL, Watson K, et al. Mesenchymal stromal cells alone or expressing interferon-β suppress pancreatic tumors in vivo, an effect countered by anti-inflammatory treatment. Cytotherapy 2010; 12:615-625.
135. Jing W, Chen Y, Lu L, Hu X, Shao C, Zhang Y, et al. Human umbilical cord blood–derived mesenchymal stem cells producing IL15 eradicate established pancreatic tumor in syngeneic mice. Mol Cancer Ther 2014; 13:2127-2137.
136. Sun Y-P, Zhang B-L, Duan J-W, Wu H-H, Wang B-Q, Yu Z-P, et al. Effect of NK4 transduction in bone marrow-derived mesenchymal stem cells on biological characteristics of pancreatic cancer cells. Int J Mol Sci 2014; 15:3729-3745.
137. Loebinger MR, Eddaoudi A, Davies D, Janes SM. Mesenchymal stem cell delivery of TRAIL can eliminate metastatic cancer. Cancer Res 2009; 69:4134-4142.
138. Xia L, Peng R, Leng W, Jia R, Zeng X, Yang X, et al. TRAIL-expressing gingival-derived mesenchymal stem cells inhibit tumorigenesis of tongue squamous cell carcinoma. J Dent Res 2015; 94:219-228.
139. Du L, Liang Q, Ge S, Yang C, Yang P. The growth inhibitory effect of human gingiva-derived mesenchymal stromal cells expressing interferon-β on tongue squamous cell carcinoma cells and xenograft model. Stem Cell Res Ther 2019; 10:224.
140. Li L, Li F, Tian H, Yue W, Li S, Chen G. Human mesenchymal stem cells with adenovirus-mediated TRAIL gene transduction have antitumor effects on esophageal cancer cell line Eca-109. Acta Biochim Biophys Sin 2014; 46:471-476.
141. He Z, Li W, Zheng T, Liu D, Zhao S. Human umbilical cord mesenchymal stem cells-derived exosomes deliver microRNA-375 to downregulate ENAH and thus retard esophageal squamous cell carcinoma progression. J Exp Clin Cancer Res 2020; 39:1-18.
142. You MH, Kim WJ, Shim W, Lee SR, Lee G, Choi S, et al. Cytosine deaminase-producing human mesenchymal stem cells mediate an antitumor effect in a mouse xenograft model. J Gastroenterol Hepatol 2009; 24:1393-1400.
143. Mao W, Zhu X, Tang D, Zhao Y, Zhao B, Ma G, et al. TNF-α expression in the UCB-MSCs as stable source inhibits gastric cancers growth in nude mice. Cancer Invest 2012; 30:463-472.
144. Mauri DN, Ebner R, Montgomery RI, Kochel KD, Cheung TC, Yu G-L, et al. LIGHT, a new member of the TNF superfamily, and lymphotoxin α are ligands for herpesvirus entry mediator. Immunity 1998; 8:21-30.
145. Shi G, Luo H, Wan X, Salcedo TW, Zhang J, Wu J. Mouse T cells receive costimulatory signals from LIGHT, a TNF family member. Blood 2002; 100:3279-3286.
146. Zhu X, Su D, Xuan S, Ma G, Dai Z, Liu T, et al. Gene therapy of gastric cancer using LIGHT-secreting human umbilical cord blood-derived mesenchymal stem cells. Gastric Cancer 2013; 16:155-166.
147. Zhu Y, Cheng M, Yang Z, Zeng C-Y, Chen J, Xie Y, et al. Mesenchymal stem cell-based NK4 gene therapy in nude mice bearing gastric cancer xenografts. Drug Des Devel Ther 2014; 8:2449.
148. Li T, Song B, Du X, Wei Z, Huo T. Effect of bone-marrow-derived mesenchymal stem cells on high-potential hepatocellular carcinoma in mouse models: an intervention study. Eur J Med Res 2013; 18:34.
149. Tang YM, Bao WM, Yang JH, Ma LK, Yang J, Xu Y, et al. Umbilical cord-derived mesenchymal stem cells inhibit growth and promote apoptosis of HepG2 cells. Mol Med Rep 2016; 14:2717-2724.
150. Mueller L, Luetzkendorf J, Widder M, Nerger K, Caysa H, Mueller T. TRAIL-transduced multipotent mesenchymal stromal cells (TRAIL-MSC) overcome TRAIL resistance in selected CRC cell lines in vitro and in vivo. Cancer Gene Ther 2011; 18:229-239.
151. Li G, Miao F, Zhu J, Chen Y. Antiangiogenesis gene therapy for hepatocellular carcinoma via systemic injection of mesenchymal stem cells engineered to secrete soluble Flt1. Mol Med Rep 2017; 16:5799-5806.
152. Zhang B, Shan H, Li D, Li Z-R, Zhu K-S, Jiang Z-B. The inhibitory effect of MSCs expressing TRAIL as a cellular delivery vehicle in combination with cisplatin on hepatocellular carcinoma. Cancer Biol Ther 2012; 13:1175-1184.
153. Moniri M, Sun X, Rayat J, Dai D, Ao Z, He Z, et al. TRAIL-engineered pancreas-derived mesenchymal stem cells: characterization and cytotoxic effects on pancreatic cancer cells. Cancer Gene Ther 2012; 19:652-658.
154. Schug C, Gupta A, Urnauer S, Steiger K, Cheung PF-Y, Neander C, et al. A novel approach for image-guided 131I therapy of pancreatic ductal adenocarcinoma using mesenchymal stem cell-mediated NIS gene delivery. Mol Cancer Res 2019; 17:310-320.

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