سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Mihaylova, Anita, Doncheva, Nina, Zlatanova, Hristina, Delev, Delian, Ivanovska, Mariya, Koeva, Yvetta, Murdjeva, Marianna, Kostadinov, Ilia. (1400). Dopaminergic agonist pramipexole improves memory and increases IL-10 production in LPS-challenged rats. , 24(5), 577-585. doi: 10.22038/ijbms.2021.50439.11488
Anita Mihaylova; Nina Doncheva; Hristina Zlatanova; Delian Delev; Mariya Ivanovska; Yvetta Koeva; Marianna Murdjeva; Ilia Kostadinov. "Dopaminergic agonist pramipexole improves memory and increases IL-10 production in LPS-challenged rats". , 24, 5, 1400, 577-585. doi: 10.22038/ijbms.2021.50439.11488
Mihaylova, Anita, Doncheva, Nina, Zlatanova, Hristina, Delev, Delian, Ivanovska, Mariya, Koeva, Yvetta, Murdjeva, Marianna, Kostadinov, Ilia. (1400). 'Dopaminergic agonist pramipexole improves memory and increases IL-10 production in LPS-challenged rats', , 24(5), pp. 577-585. doi: 10.22038/ijbms.2021.50439.11488
Mihaylova, Anita, Doncheva, Nina, Zlatanova, Hristina, Delev, Delian, Ivanovska, Mariya, Koeva, Yvetta, Murdjeva, Marianna, Kostadinov, Ilia. Dopaminergic agonist pramipexole improves memory and increases IL-10 production in LPS-challenged rats. , 1400; 24(5): 577-585. doi: 10.22038/ijbms.2021.50439.11488

Dopaminergic agonist pramipexole improves memory and increases IL-10 production in LPS-challenged rats

Iranian Journal of Basic Medical Sciences
مقاله 3، دوره 24، شماره 5، مرداد 2021، صفحه 577-585    اصل مقاله (648.4 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2021.50439.11488
نویسندگان
Anita Mihaylova* 1؛ Nina Doncheva1؛ Hristina Zlatanova2؛ Delian Delev2؛ Mariya Ivanovska3؛ Yvetta Koeva4؛ Marianna Murdjeva3؛ Ilia Kostadinov2
1Department of Pharmacology and Drug Toxicology, Faculty of Pharmacy, Medical University of Plovdiv, Bulgaria
2Department of Pharmacology and Clinical Pharmacology, Medical Faculty, Medical University of Plovdiv, Bulgaria
3Department of Microbiology and Immunology, Research Institute (RIMU), Faculty of Pharmacy, Medical University of Plovdiv, Bulgaria
4Department of Anatomy, Histology and Embryology, Medical Faculty, Medical University of Plovdiv, Bulgaria
چکیده
Objective(s): A variety of cytokines are involved in cognitive functioning. Balance restoration between protective and degenerative neuro-inflammation is of great interest in newer therapeutic approaches. In the current study, we investigated the effect of pramipexole (PMX) on memory functions, hippocampal amyloid deposition, serum cytokines, and brain-derived neurotrophic factor (BDNF)  levels in lipopolysaccharide (LPS) challenged-rats.
Materials and Methods: Male Wistar rats were divided into 5 groups (n=8): control (saline), lipoppolysacharide (LPS 250 mcg/kg bw), and experimental groups (LPS and PMX 0.5, 1, and 3 mg/kg bw). Learning and memory were assessed by the novel object recognition test (NORT), Y-maze, and step-through test. Immunological and histological assays were performed.
Results: In memory tasks, LPS-challenged rats showed reduction in the observed parameters. In NORT, PMX 1 mg/kg increased recognition index compared with controls, whereas the other two doses increased this index only against the LPS-control. In Y-maze, all doses of PMX significantly had increased alternation when compared with LPS. In the step-through test, only the lowest dose of PMX extended the latency compared with LPS. Histological examination revealed that PMX at doses of 0.5 and 1 mg/kg reduced amyloid deposition in the hippocampus. Interleukin (IL)-10 serum levels were elevated by 1 mg/kg PMX. Tumor necrosis factor (TNF)-α and transforming growth factor (TGF)-β1 serum levels remained under the detectable minimum in all experimental groups. PMX at all doses significantly decreased BDNF serum concentration.
Conclusion: In rats with LPS-induced neuro-inflammation PMX improved hippocampal-dependent memory and exerted immuno-modulatory effects by increasing IL-10.
کلیدواژه‌ها
Amyloid؛ Cytokines؛ Hippocampus؛ Lipopolysaccharide؛ Neuroinflammation؛ Pramipexole
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