سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Ebrahimpour, Adel, Chehrassan, Mohammadreza, Sadighi, Mehrdad, Karimi, Amin, Azizmohammad Looha, Mehdi, jafari kafiabadi, meisam, Biglari, Farsad, Akbari, Mohammad Esmaeil. (1400). Soft Tissue Sarcoma of Extremities: Descriptive Epidemiological Analysis According to National Population-based Study. , 10(1), 67-77. doi: 10.22038/abjs.2021.53750.2676
Adel Ebrahimpour; Mohammadreza Chehrassan; Mehrdad Sadighi; Amin Karimi; Mehdi Azizmohammad Looha; meisam jafari kafiabadi; Farsad Biglari; Mohammad Esmaeil Akbari. "Soft Tissue Sarcoma of Extremities: Descriptive Epidemiological Analysis According to National Population-based Study". , 10, 1, 1400, 67-77. doi: 10.22038/abjs.2021.53750.2676
Ebrahimpour, Adel, Chehrassan, Mohammadreza, Sadighi, Mehrdad, Karimi, Amin, Azizmohammad Looha, Mehdi, jafari kafiabadi, meisam, Biglari, Farsad, Akbari, Mohammad Esmaeil. (1400). 'Soft Tissue Sarcoma of Extremities: Descriptive Epidemiological Analysis According to National Population-based Study', , 10(1), pp. 67-77. doi: 10.22038/abjs.2021.53750.2676
Ebrahimpour, Adel, Chehrassan, Mohammadreza, Sadighi, Mehrdad, Karimi, Amin, Azizmohammad Looha, Mehdi, jafari kafiabadi, meisam, Biglari, Farsad, Akbari, Mohammad Esmaeil. Soft Tissue Sarcoma of Extremities: Descriptive Epidemiological Analysis According to National Population-based Study. , 1400; 10(1): 67-77. doi: 10.22038/abjs.2021.53750.2676

Soft Tissue Sarcoma of Extremities: Descriptive Epidemiological Analysis According to National Population-based Study

The Archives of Bone and Joint Surgery
مقاله 11، دوره 10، شماره 1، فروردین 2022، صفحه 67-77    اصل مقاله (1016.44 K)
نوع مقاله: RESEARCH PAPER
شناسه دیجیتال (DOI): 10.22038/abjs.2021.53750.2676
نویسندگان
Adel Ebrahimpour1؛ Mohammadreza Chehrassan2؛ Mehrdad Sadighi2؛ Amin Karimi3؛ Mehdi Azizmohammad Looha4؛ meisam jafari kafiabadi2؛ Farsad Biglari* 5؛ Mohammad Esmaeil Akbari6
11 Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran 2 Department of Orthopedic Surgery, Shohadaye Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran 5 Physiotherapy Research Center, Shahid Beheshti University of Medical Sciences
21 Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran 2 Department of Orthopedic Surgery, Shohadaye Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3Department of Orthopedic Surgery, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4Department of Biostatics, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
52 Department of Orthopedic Surgery, Shohadaye Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran 5 Physiotherapy Research Center, Shahid Beheshti University of Medical Sciences
6Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
چکیده
Background: Soft-Tissue Sarcoma (STS) is a heterogeneous group of neoplasms of mesenchymal origin, occurring in connective tissues. According to previously conducted studies, STS accounts for approximately 1% and 7-%15% of adult and pediatric malignancies, respectively. Almost 50%-60% of sarcomas arise from extremities and usually present as a large painless or rarely painful soft-tissue mass. The present study aimed to describe the epidemiology of soft-tissue sarcomas, especially in the Iranian population. Methods: This epidemiological study of limb soft-tissue sarcoma was conducted based on Iran National Cancer Registry data (INCR) between 2009 and 2014. Patients with soft-tissue sarcoma confirmed by histopathological studies were included, and data were classified based on the International Classification of Diseases for Oncology (first revision-third edition [ICD-O-3]) and analyzed. Descriptive analysis was performed to extract age-standardized and age-specific incidence rates. Results: A total of 2, 593 patients (1,476 males and 1,117 females) were enrolled and assessed in the present study. The age-standardized incidence rate(ASIR) of total soft tissue sarcomas was 6.34 per million person-years. In addition, the highest and lowest ASIR scores stratified by age were observed in patients aged above 65 and under 0 with the value of 19.61 (95% CI:17.91-21.30) and 1.91 (95% CI 1.69, 2.13) per million, respectively. Limb soft tissue sarcomas stratified by gender were dominant in males, and it was statistically significant (P<0.05). The most common extremity soft tissue sarcomas subtypes were mesenchymal tumor (12.26%), spindle cell sarcoma (12.18%), and malignant fibrous histiocytoma (11.45%). Conclusion: As evidenced by the results of the present study, the ASIR of soft tissue sarcoma dramatically increased with age, and the peak ASIR occurred in the age range of above 65 years. The incidence rate of soft tissue sarcomas analyzed by disease site was higher in hip and lower limb than upper limb and pelvis region, and it was detected consistently in all age groups and both genders. Level of evidence: IV
کلیدواژه‌ها
Sarcoma؛ Soft Tissue؛ Extremities؛ Soft Tissue Neoplasm
مراجع
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