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Eshraghi, Nooshin, Mohamadianamiri, Mahdiss, Ebrahimi, Maryam, Karimi, Fahimeh. (1400). The Effect of Sildenafil on Intrauterine Growth Restriction (IUGR) of Fetus with Gestational Age above 28 Weeks and Neonatal Outcomes. , 9(6), 13643-13651. doi: 10.22038/ijp.2021.48984.3928
Nooshin Eshraghi; Mahdiss Mohamadianamiri; Maryam Ebrahimi; Fahimeh Karimi. "The Effect of Sildenafil on Intrauterine Growth Restriction (IUGR) of Fetus with Gestational Age above 28 Weeks and Neonatal Outcomes". , 9, 6, 1400, 13643-13651. doi: 10.22038/ijp.2021.48984.3928
Eshraghi, Nooshin, Mohamadianamiri, Mahdiss, Ebrahimi, Maryam, Karimi, Fahimeh. (1400). 'The Effect of Sildenafil on Intrauterine Growth Restriction (IUGR) of Fetus with Gestational Age above 28 Weeks and Neonatal Outcomes', , 9(6), pp. 13643-13651. doi: 10.22038/ijp.2021.48984.3928
Eshraghi, Nooshin, Mohamadianamiri, Mahdiss, Ebrahimi, Maryam, Karimi, Fahimeh. The Effect of Sildenafil on Intrauterine Growth Restriction (IUGR) of Fetus with Gestational Age above 28 Weeks and Neonatal Outcomes. , 1400; 9(6): 13643-13651. doi: 10.22038/ijp.2021.48984.3928

The Effect of Sildenafil on Intrauterine Growth Restriction (IUGR) of Fetus with Gestational Age above 28 Weeks and Neonatal Outcomes

Journal of Pediatric Perspectives
مقاله 2، دوره 9، شماره 6 - شماره پیاپی 90، شهریور 2021، صفحه 13643-13651    اصل مقاله (527.6 K)
شناسه دیجیتال (DOI): 10.22038/ijp.2021.48984.3928
نویسندگان
Nooshin Eshraghi1؛ Mahdiss Mohamadianamiri2؛ Maryam Ebrahimi3؛ Fahimeh Karimi* 3
1Fellowship of Perinatal, Department of Obstetrics and Gynecology, Akbarabadi Clinical Research Development Center, Iran University of Medical Sciences, Tehran, Iran AND Department of Obstetrics and Gynecology, Iran University of Medical Sciences, Akbarabadi Teaching Hospital, Tehran, Iran.
2Fellowship of Gyneconcology, Department of Obstetrics and Gynecology, Akbarabadi Clinical Research Development Center, Iran University of Medical Sciences, Tehran, Iran.
3Department of Obstetrics and Gynecology, Iran University of Medical Sciences, Akbarabadi Teaching Hospital, Tehran, Iran.
چکیده
Background
Intrauterine growth restriction (IUGR) is one of the main causes of mortality and morbidities of the perinatal period. This study aimed to investigate the therapeutic effects of sildenafil on Intrauterine Growth Restriction (IUGR) of fetus.
Materials and Methods: This study was a double-blinded clinical trial performed on 80 pregnant women with gestational age above 28 weeks and fetal weight below 10% percentile and AC below 3%. The patients were divided into two groups: the recipient of 25 mg of oral sildenafil daily (n=40) (made by Marham Darou in Tehran, Iran), and the group, receiving placebo (n=40). The two groups were evaluated weekly in terms of ultrasound factors such as fetal weight, AC, PI, and RI of the umbilical and cerebral arteries, and S / D of the umbilical artery.
Results: The mean age of the patients was 30.86 ± 5.77 years. Regarding MCA.PI, UA.PI, S / D, MCA.R and UA.RI indices, it was observed that these indices improved significantly in the intervention group (P <0.05). In the intervention group, after receiving the drug, the mean number of days to delivery was 12.05 days, and in the control group, after receiving placebo was 10.00 days (P = 0.001). The mean birth weight and score of Apgar minutes 1 and 5 in the intervention group was significantly higher than the control group (P <0.05).
Conclusion
Sildenafil can improve MCA.PI, UA.PI, S / D, MCA.R and UA.RI indices. Sildenafil increase the mean birth weight and score of Apgar minutes 1 and 5. Additionally, hospitalization in the NICU after taking sildenafil is shortened.
کلیدواژه‌ها
Fetus؛ Gestational age؛ IUGR؛ Neonate؛ Sildenafil
آمار
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