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Mahdavifard, Sina, Dehghani, Razieh, Jeddi, Farhad, Najafzadeh, Nowruz. (1399). Thiamine reduced metabolic syndrome symptoms in rats via down-regulation of hepatic nuclear factor-kβ and induction activity of glyoxalase-I. , 24(3), 293-299. doi: 10.22038/ijbms.2021.53707.12086
Sina Mahdavifard; Razieh Dehghani; Farhad Jeddi; Nowruz Najafzadeh. "Thiamine reduced metabolic syndrome symptoms in rats via down-regulation of hepatic nuclear factor-kβ and induction activity of glyoxalase-I". , 24, 3, 1399, 293-299. doi: 10.22038/ijbms.2021.53707.12086
Mahdavifard, Sina, Dehghani, Razieh, Jeddi, Farhad, Najafzadeh, Nowruz. (1399). 'Thiamine reduced metabolic syndrome symptoms in rats via down-regulation of hepatic nuclear factor-kβ and induction activity of glyoxalase-I', , 24(3), pp. 293-299. doi: 10.22038/ijbms.2021.53707.12086
Mahdavifard, Sina, Dehghani, Razieh, Jeddi, Farhad, Najafzadeh, Nowruz. Thiamine reduced metabolic syndrome symptoms in rats via down-regulation of hepatic nuclear factor-kβ and induction activity of glyoxalase-I. , 1399; 24(3): 293-299. doi: 10.22038/ijbms.2021.53707.12086

Thiamine reduced metabolic syndrome symptoms in rats via down-regulation of hepatic nuclear factor-kβ and induction activity of glyoxalase-I

Iranian Journal of Basic Medical Sciences
مقاله 4، دوره 24، شماره 3، خرداد 2021، صفحه 293-299    اصل مقاله (580.79 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2021.53707.12086
نویسندگان
Sina Mahdavifard* 1؛ Razieh Dehghani1؛ Farhad Jeddi2؛ Nowruz Najafzadeh3
1Department of Clinical Biochemistry, Ardabil University of Medical Sciences, Ardabil, Iran
2Department of Genetics and Pathology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
3Research Laboratory for Embryology and Stem Cells, Department of Anatomical Sciences, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
چکیده
Objective(s): Metabolic syndrome (MS) is a cause of death worldwide. The hepatic nuclear factor- NF-kβ (NF-kβ) is the cardinal player of hepatic homeostasis, insulin sensitivity, and lipid metabolism. Thus, we investigated the effect of thiamine on hepatic gene expression of NF-kβ and its levels of activators in MS rats.
Materials and Methods: Male Wistar rats were randomly divided into 4 equal groups (ten rats in each group): normal, MS, and two alike groups under thiamine treatment. MS was induced in rats with a high sucrose solution (40 % in drinking water) for 4 months. Treated groups of rats received 0.18 % of thiamine daily in drinking water. Hematoxylin-Eosin stains were employed to determine the histopathological changes of the liver. Metabolic profile, glycation products, oxidative stress, inflammatory markers, the activity of glyoxalase-I, as well as NF-kβ hepatic expression of all rat groups, were determined.
Results: Acute hepatitis was not observed in the livers of the thiamine treated MS rats. Besides, the treatment showed an advantageous effect on glucose, lipid metabolism, and body weight via down-regulation of hepatic NF-kβ and induction of glyoxalase system activity. Furthermore, the treatment decreased diverse glycation, oxidative stress, and inflammatory markers (P>0.001).
Conclusion: Thiamine decreased body weight and improved metabolism and activity of glyoxalase-I in MS rats with anti-glycation, antioxidant, and anti-inflammatory activities. Further, the treatment had a hepato-protective effect via reduction of NF-kβ signaling.
کلیدواژه‌ها
Glycation Glyoxalase؛ I Metabolic syndrome Nuclear factor؛ kβ Thiamine
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