سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Akbari Korhkheyli, Vahid, Mishan, Mohammad Amir, Khonakdar Tarsi, Abbas, Mahrooz, Abdolkarim, Rezaei Kanavi, Mozhgan, Hafezi-Moghadam, Ali, Bagheri, Abouzar. (1399). MicroRNAs may provide new strategies in the treatment and diagnosis of diabetic retinopathy: Importance of VEGF. , 24(3), 267-279. doi: 10.22038/ijbms.2021.52164.11807
Vahid Akbari Korhkheyli; Mohammad Amir Mishan; Abbas Khonakdar Tarsi; Abdolkarim Mahrooz; Mozhgan Rezaei Kanavi; Ali Hafezi-Moghadam; Abouzar Bagheri. "MicroRNAs may provide new strategies in the treatment and diagnosis of diabetic retinopathy: Importance of VEGF". , 24, 3, 1399, 267-279. doi: 10.22038/ijbms.2021.52164.11807
Akbari Korhkheyli, Vahid, Mishan, Mohammad Amir, Khonakdar Tarsi, Abbas, Mahrooz, Abdolkarim, Rezaei Kanavi, Mozhgan, Hafezi-Moghadam, Ali, Bagheri, Abouzar. (1399). 'MicroRNAs may provide new strategies in the treatment and diagnosis of diabetic retinopathy: Importance of VEGF', , 24(3), pp. 267-279. doi: 10.22038/ijbms.2021.52164.11807
Akbari Korhkheyli, Vahid, Mishan, Mohammad Amir, Khonakdar Tarsi, Abbas, Mahrooz, Abdolkarim, Rezaei Kanavi, Mozhgan, Hafezi-Moghadam, Ali, Bagheri, Abouzar. MicroRNAs may provide new strategies in the treatment and diagnosis of diabetic retinopathy: Importance of VEGF. , 1399; 24(3): 267-279. doi: 10.22038/ijbms.2021.52164.11807

MicroRNAs may provide new strategies in the treatment and diagnosis of diabetic retinopathy: Importance of VEGF

Iranian Journal of Basic Medical Sciences
مقاله 2، دوره 24، شماره 3، خرداد 2021، صفحه 267-279    اصل مقاله (751.4 K)
نوع مقاله: Review Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2021.52164.11807
نویسندگان
Vahid Akbari Korhkheyli1؛ Mohammad Amir Mishan2؛ Abbas Khonakdar Tarsi3؛ Abdolkarim Mahrooz3؛ Mozhgan Rezaei Kanavi2؛ Ali Hafezi-Moghadam4، 5؛ Abouzar Bagheri* 3
1Department of Clinical Biochemistry and Medical Genetics, Student Research Committee, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
2Ocular Tissue Engineering Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3Department of Clinical Biochemistry and Medical Genetics, Molecular and Cell Biology Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
4Molecular Biomarkers Nano-Imaging Laboratory, Brigham and Women’s Hospital, Boston, Massachusetts, USA
5Department of Radiology, Harvard Medical School, Boston, Massachusetts, USA
چکیده
Diabetic retinopathy (DR) is ocular microvascular complications of diabetes mellitus. Along with the increasing prevalence of diabetes worldwide, DR has come into the major cause of human blindness. Several studies have demonstrated the important roles of the expression alteration in the proteins contributed to vascular dysfunction during DR, especially vascular endothelial growth factor (VEGF). However, there is a need for further mechanistic research in this context to design new therapeutic and diagnostic programs. MicroRNAs (miRNAs, miRs) have been introduced as key controllers of gene expression in a variety of biological processes including differentiation, proliferation, and metabolism. Altered expression of miRNAs during DR development indicates a close relationship between these regulatory molecules and DR through regulating gene expressions. This review discusses and updates the functions of miRNA-dependent pathways and key roles of VEGF in the DR, which may increase our understanding and ability to target these small but important molecules to efficiently improve therapeutic and diagnostic approaches.
کلیدواژه‌ها
Diabetic retinopathy؛ Gene regulation؛ Molecular targeting؛ miRNAs؛ VEGF
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