Khalili, Azadeh, Fallah, Parviz, Hashemi, Seyed Ali, Ahmadian-Attari, Mohammad Mahdi, Jamshidi, Vahid, Mazloom, Roham, Beikzadeh, Leila, Bayat, Gholamreza. (1400). New mechanistic insights into hepatoprotective activity of milk thistle and chicory quantified extract: The role of hepatic Farnesoid-X activated receptors. , 11(4), 367-379. doi: 10.22038/ajp.2020.17281
Azadeh Khalili; Parviz Fallah; Seyed Ali Hashemi; Mohammad Mahdi Ahmadian-Attari; Vahid Jamshidi; Roham Mazloom; Leila Beikzadeh; Gholamreza Bayat. "New mechanistic insights into hepatoprotective activity of milk thistle and chicory quantified extract: The role of hepatic Farnesoid-X activated receptors". , 11, 4, 1400, 367-379. doi: 10.22038/ajp.2020.17281
Khalili, Azadeh, Fallah, Parviz, Hashemi, Seyed Ali, Ahmadian-Attari, Mohammad Mahdi, Jamshidi, Vahid, Mazloom, Roham, Beikzadeh, Leila, Bayat, Gholamreza. (1400). 'New mechanistic insights into hepatoprotective activity of milk thistle and chicory quantified extract: The role of hepatic Farnesoid-X activated receptors', , 11(4), pp. 367-379. doi: 10.22038/ajp.2020.17281
Khalili, Azadeh, Fallah, Parviz, Hashemi, Seyed Ali, Ahmadian-Attari, Mohammad Mahdi, Jamshidi, Vahid, Mazloom, Roham, Beikzadeh, Leila, Bayat, Gholamreza. New mechanistic insights into hepatoprotective activity of milk thistle and chicory quantified extract: The role of hepatic Farnesoid-X activated receptors. , 1400; 11(4): 367-379. doi: 10.22038/ajp.2020.17281

New mechanistic insights into hepatoprotective activity of milk thistle and chicory quantified extract: The role of hepatic Farnesoid-X activated receptors

Avicenna Journal of Phytomedicine
دوره 11، شماره 4، مهر و آبان 2021، صفحه 367-379    اصل مقاله (1.4 M)
نوع مقاله: Original Research Article
شناسه دیجیتال (DOI): 10.22038/ajp.2020.17281
نویسندگان
Azadeh Khalili1؛ Parviz Fallah2؛ Seyed Ali Hashemi3؛ Mohammad Mahdi Ahmadian-Attari4؛ Vahid Jamshidi5؛ Roham Mazloom6؛ Leila Beikzadeh2؛ Gholamreza Bayat* 7
1Department of Physiology-Pharmacology-Medical Physic, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran. Evidence-based Phytotherapy and Complementary Medicine Research Center, Alborz University of Medical Sciences, Karaj, Iran
2Department of Medical Laboratory Sciences, Faculty of Para-Medicine, Alborz University of Medical Sciences, Karaj, Iran
3Department of Pathology, School of Medicine, Alborz University of Medical Sciences, Karaj,Iran
4Evidence-based Phytotherapy and Complementary Medicine Research Center, Alborz University of Medical Sciences, Karaj, Iran
5Department of Pharmacology and Toxicology, Faculty of Pharmacy, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran
6Department of Physiology-Pharmacology-Medical Physic, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran
7Department of Physiology-Pharmacology-Medical Physic, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran. Evidence-based Phytotherapy and Complementary Medicine Research Center, Alborz University of Medical Sciences, Karaj, Iran
چکیده
Objective: Farnesoid-X-activated receptors (FXR) are key modulators of liver regeneration. Milk thistle and Chicory are known as potent protective remedies in several liver disorders. The objective of this work was to examine the role of FXR in the hepato-healing properties of milk thistle (MTE) and chicory extracts (CE) in a rat model of acetaminophen-induced hepatotoxicity.
Materials and Methods: Male Wistar rats were randomly divided into seven groups including control, vehicle, acetaminophen (500 mg/kg/day, oral), acetaminophen plus oral MTE 200 and 400 mg/kg/day, and acetaminophen plus oral CE 500 and 1000 /kg/day for 28 days. Liver function and histology as well as the pattern of hepatic FXR expression were assessed after 4 weeks.
Results: Administration of acetaminophen was associated with a significant elevation of liver transaminase along with the architectural injuries. In contrast, chronic concomitant administration of both MTE and CE significantly restored the liver function and structural abnormality. The main molecular findings of the study revealed that the lower doses of both MTE and CE led to a marked upregulation of hepatic FXR expression.
Conclusion: Discovery of the involvement of the nuclear modulating pathways in hepatoprotective activity of the extracts, providesa new mechanistic insight which needs further investigations.
کلیدواژه‌ها
Farnesoid X receptors (FXR)؛ Acetaminophen؛ Milk thistle؛ Chicory؛ Necrosis
مراجع
آمار
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