Abdullaev F, Espinosa-Aguirre J.2004a.
Biomedical properties of saffron and its
potential use in cancer therapy and
chemoprevention trials. Cancer detect prev,
28: 426-432.
Abdullaev FI.1993a. Biological effects of
saffron.BioFactors (Oxford, England),
4:83-86
Abdullaev FI. 2002a. Cancer chemopreventive
and tumoricidal properties of saffron
(Crocus sativus L.). Expbiol med, 227: 20-
25.
Amin B, Hosseinzadeh H. 2012b. Evaluation of
aqueous and ethanolic extracts of saffron,
Crocus sativus L., and its constituents,
safranal and crocin inallodynia and
hyperalgesia induced by chronic
constriction injury model of neuropathic
pain in rats. Fitoterapia, 83: 888-895.
Amin B, Hosseinzadeh H. 2015. Analgesic and
anti-inflammatory effects of Crocus sativus
L. (saffron) Bioactive nutraceuticals and
dietary supplements in neurological and
brain disease. Elsevier, p 319-324.
Benucci M, Saviola G, Baiardi P, Manfredi M,
Puttini PS, Atzeni F.2012. Determinants of
risk infection during therapy with anti
TNF-alpha blocking agents in rheumatoid
arthritis. Open Rheumatol J, 6: 33.
Bolhassani A, Khavari A, Bathaie SZ. 2014a.
Saffron and natural carotenoids:
Biochemical activities and anti-tumor
effects. BiochimBiophysActa, 1845:20-30
Bruce B, FriesJ.F. 2009a. The Health
Assessment Questionnaire (HAQ)© and
the Improved HAQ. Clin Exp Rheumatol,
23: 14-18.
Duesterdieck-Zellmer KF, Driscoll N, Ott
JF.2012b. Concentration-dependent effects
of tiludronate on equine articular cartilage
explants incubated with and without
interleukin-1β. Am J Vet Res, 73: 1530-
1539.
Edwards C, Cooper C. 2006a. Early
environmental factors and rheumatoid
arthritis. Clin Exp Immunol, 143: 1-5.
Fransen, J, Creemers MCW and Van Riel
PLCM. 2004b. Remission in rheumatoid
arthritis: agreement of the disease activity
score (DAS28) with the ARA preliminary
remission criteria. Rheumatology, 43:
1252-1255.
Ghorbani M. 2008b. The efficiency of saffron’s
marketing channel in Iran. World Appl Sci
J, 4: 523-527.
Gout B, Bourges C, Paineau-Dubreuil S. 2010b.
Satiereal, a Crocus sativus L extract,
reduces snacking and increases satiety in a
randomized placebo-controlled study of
mildly overweight, healthy women. Nutr
Res, 30: 305-313.
Hamidi, Z. and Aryaeian, N. and Abolghasemi,
J. and Shirani, F. and Hadidi, M. and
Fallah, S. and Moradi, N. 2020b. The effect
of saffron supplement on clinical outcomes
and metabolic profiles in patients with
active rheumatoid arthritis: A randomized,
double-blind, placebo-controlled clinical
trial. Phytother Res, 34: 1650-1658.
Hertzog, M.A., 2008a. Considerations in
determining sample size for pilot
studies. Res Nurs Health, 31:180-191.
Hosseinzadeh H.2014a. Saffron: a herbal
medicine of third millennium. Jundishapur
j nat pharm prod, 9: 1.
Hosseinzadeh H, Modaghegh MH, Saffari Z.
2009b. Crocus sativus L.(Saffron) extract
and its active constituents (crocin and
safranal) on ischemia-reperfusion in rat
skeletal muscle. EVID-Based Compl Alt, 6:
343-350.
Hosseinzadeh H, Younesi HM. 2002a.
Antinociceptive and anti-inflammatory
effects of Crocus sativus L. stigma and
petal extracts in mice. BMC
PharmacolToxicol, 2: 7.
Hreggvidsdottir HS, Noordenbos T, Baeten DL.
2014a. Inflammatory pathways in
spondyloarthritis. Mol Immunol, 57: 28-37.
Hsu J, Chou F, Lee M, et al. 1999b. Suppression
of the TPA-induced expression of nuclearprotooncogenes in mouse epidermis by
crocetin via antioxidant activity.
Anticancer Res, 19: 4221-4227.
Javadi B, Sahebkar A, Emami SA. 2013a. A
survey on saffron in major Islamic
traditional medicine books. Iran J Basic
Med Sci, 16: 1.
Kasper D, Harrison TR. 2005. Harrison's
principles of internal medicine. Vol. 2.
McGraw-Hill, Medical Publishing Division
Kay J, and Upchurch KS, 2012. ACR/EULAR
2010 rheumatoid arthritis
classificationcriteria. Rheumatology, 51(su
ppl_6), pp.vi5-vi9.
Korani S, Korani M, Sathyapalan T, Sahebkar
A. 2019. Therapeutic effects of Crocin in
autoimmune diseases: A review.
Sahebari et al.
AJP, Vol. 11, No. 4, Jul-Aug 2021 342
BioFactors, 45(6), pp. 835-843.
Lee I-A, Lee JH, Baek N-I, Kim D-H. 2005b.
Antihyperlipidemic effect of crocin
isolated from the fructus of Gardenia
jasminoides and its metabolite crocetin.
Biol Pharm Bull, 28: 2106-2110.
Li X, Jiang C, Zhu W. 2017b. Crocin reduces
the inflammation response in rheumatoid
arthritis. Biosci Biotech Bioch, 81: 891-
898.
Liu W, Sun Y, Cheng Z, Guo Y, Liu P, Wen Y.
2018a. Crocin exerts anti-inflammatory and
anti-arthritic effects on type II collageninduced arthritis in rats. Pharm Biol, 56:
209-216.
Mansoori P, Akhondzadeh S, Raisi F, Ghaeli
P.2011. A randomized, double-blind,
placebo-controlled study of safety of the
adjunctive saffron on sexual dysfunction
induced by a selective serotonin reuptake
inhibitor. J Med Plant Res, 1: 121-130.
Modaghegh M-H, Shahabian M, Esmaeili H-A,
Rajbai O.2008. Safety evaluation of saffron
(Crocus sativus) tablets in healthy
volunteers. Phytomedicine, 15: 1032-1037.
Moghimi N, Rahimi E, Ghaderi B, Saeeedi
A.2014b. Relationship between platelet
indices and severity of rheumatoid arthritis
according to DAS28 criteria. Scientific J
Kurdistan Univ Med Sci, 19: 1-8.
Molina V, Shoenfeld Y.2005b. Infection,
vaccines and other environmental triggers
of autoimmunity. J Autoimmun, 38: 235-
245.
Nair SC, Kurumboor S, Hasegawa J. 1995b.
Saffron chemoprevention in biology and
medicine: a review. Cancer Biother
Radiopharm, 10: 257-264.
Nazary-Moghadam S, Zeinalzadeh A, Salavati
M, Almasi S, Negahban H. 2017.
Adaptation, reliability and validity testing
of a Persian version of the Health
Assessment Questionnaire-Disability Index
in Iranian patients with rheumatoid
arthritis. J J Body Mov Ther, 21: 133-140.
NG KP, AUSTIN P, AMERATUNGA R,
McQUEEN F. 2006b. Role of
anticycliccitrullinated peptide 2 assay in
long‐standing rheumatoid arthritis. APLAR
J Rheumatol, 9: 211-215.
Padyukov L, Silva C, Stolt P, Alfredsson L.
2004. A gene–environment interaction
between smoking and shared epitope genes
in HLA–DR provides a high risk of
seropositive rheumatoid arthritis. Arthritis
Rheum, 50: 3085-3092.
Rastmanesh R, Rabiee S, Shaabani Y, Mazinani
H, Ebrahimi AA, Jamshidi AR. 2010b.
Validation of the Persian version of the
Stanford Health Assessment Questionnaire
(HAQ) in patients with rheumatoid
arthritis. J Paramed Sci, 1: 16-25.
Rathore B, Jaggi K, Thakur SK, Mathur A.
2015b. Anti-inflammatory activity of
Crocus sativus extract in experimental
arthritis. Int J Pharm Sci Res, 6: 1473-1478.
Sahebari M, Mahmoudi Z, Rabe SZT,
Haghmorad D. 2011a. Inhibitory effect of
aqueous extract of Saffron (Crocus sativus
L.) on adjuvant-induced arthritis in Wistar
rat. Pharmacologyonline, 3: 802-808.
Schmidt M, Betti G, Hensel A. 2007. Saffron in
phytotherapy: pharmacology and clinical
uses. Wien Med Wochenschr, 157: 315.
Tremblay I, Beaulieu Y, Bernier A, Crombez
G, Laliberté S, Thibault P, Velly AM,
Sullivan MJ. 2008. Pain catastrophizing
scale for francophone adolescents: a
preliminary validation. Pain Res Manag, 1;
13.
Tobón GJ, Youinou P, Saraux A. 2010b. The
environment, geo-epidemiology, and
autoimmune disease: Rheumatoid arthritis.
Autoimmun Rev, 9: A288-A292.
Van Der Heijde D, Van Der Helm-Van, AH,
Aletaha D, Bingham CO, Burmester GR,
Dougados M, Emery P, Felson D, Knevel
R, Kvien TK, Landewé RB. 2013a.
EULAR definition of erosive disease in
light of the 2010 ACR/EULAR rheumatoid
arthritis classification criteria. Ann Rheum
Dis, 72: 479-481.
Yarijani ZM, Najafi H, Madani SH. 2016b.
Protective effect of crocin on gentamicininduced nephrotoxicity in rats. Iran J Basic
Med Sci, 19: 337.
Zamani Taghizadeh Rabe S, Sahebari M,
Mahmoudi Z, Hosseinzadeh H. 2015b.
Inhibitory effect of Crocus sativus L.
ethanol extract on adjuvant-induced
arthritis. Food Agr Immunol, 26: 170-180