Zarei, Fatemeh, Mobini, Moein, Jafarzadeh Esfehani, reza, Khalesi, Maryam, Vakili, Rahim. (1399). The Relation between Karyotype Findings and Gonadotropin Levels in Pediatric Turner’s syndrome Patients. , 9(2), 13005-13011. doi: 10.22038/ijp.2020.54327.4296
Fatemeh Zarei; Moein Mobini; reza Jafarzadeh Esfehani; Maryam Khalesi; Rahim Vakili. "The Relation between Karyotype Findings and Gonadotropin Levels in Pediatric Turner’s syndrome Patients". , 9, 2, 1399, 13005-13011. doi: 10.22038/ijp.2020.54327.4296
Zarei, Fatemeh, Mobini, Moein, Jafarzadeh Esfehani, reza, Khalesi, Maryam, Vakili, Rahim. (1399). 'The Relation between Karyotype Findings and Gonadotropin Levels in Pediatric Turner’s syndrome Patients', , 9(2), pp. 13005-13011. doi: 10.22038/ijp.2020.54327.4296
Zarei, Fatemeh, Mobini, Moein, Jafarzadeh Esfehani, reza, Khalesi, Maryam, Vakili, Rahim. The Relation between Karyotype Findings and Gonadotropin Levels in Pediatric Turner’s syndrome Patients. , 1399; 9(2): 13005-13011. doi: 10.22038/ijp.2020.54327.4296

The Relation between Karyotype Findings and Gonadotropin Levels in Pediatric Turner’s syndrome Patients

Journal of Pediatric Perspectives
مقاله 11، دوره 9، شماره 2 - شماره پیاپی 86، اردیبهشت 2021، صفحه 13005-13011    اصل مقاله (393.48 K)
شناسه دیجیتال (DOI): 10.22038/ijp.2020.54327.4296
نویسندگان
Fatemeh Zarei1؛ Moein Mobini1؛ reza Jafarzadeh Esfehani2؛ Maryam Khalesi3؛ Rahim Vakili* 1
1Department of Pediatric Endocrinology and Metabolism, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
2Department of Medical Genetics, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran.
3Department of Pediatrics, Ghaem Medical Center, Mashhad University of medical sciences, Mashhad, Iran.
چکیده
Background
Abnormal pubertal development and fertility are among the frequent complications in Turner’s syndrome. Although elevated level of gonadotropins in Turner’s syndrome patients is well documented, the possible correlation with the karyotype findings and anthropometric features of patients is not clearly addressed. The present report aimed to evaluate the relation between the follicle-stimulating hormone (FSH) serum level and cytogenetic findings in Iranian Turner’s syndrome patients.
Materials and Methods: Abnormal pubertal development and fertility are among the frequent complications in Turner’s syndrome. Although elevated level of gonadotropins in Turner’s syndrome patients is well documented, the possible correlation with the karyotype findings and anthropometric features of patients is not clearly addressed. The present report aimed to evaluate the relation between the follicle-stimulating hormone (FSH) serum level and cytogenetic findings in Iranian Turner’s syndrome patients.
Results: The mean age of the Turner’s syndrome patients was 9.78 years and most of the patients were mosaic for Turner syndrome (54.3%). Although the FSH level increased, there was not any significant different between the FSH level in the initial evaluation and the second evaluation within the entire study population (P=0.605). Among those who were mosaic for Turner’s syndrome and those with 45,XO karyotype, the FSH level increased during the follow up (P=0.476, and P=0.357, respectively).
Conclusion
The present study demonstrated that although Turner’s syndrome patients face abnormal FSH levels, there is not any significant relation between the cytogenetic findings as well as anthropometric characteristics including height, weight and BMI with the serum FSH levels.
کلیدواژه‌ها
Follicle-Stimulating Hormone؛ Karyotype؛ Turner’s syndrome
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