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Sabbagh, Parisa, Rajabnia, Mehdi, Maali, AMirhosein, Ferdosi-Shahandashti, Elaheh. (1399). Integron and its role in antimicrobial resistance: A literature review on some bacterial pathogens. , 24(2), 136-142. doi: 10.22038/ijbms.2020.48905.11208
Parisa Sabbagh; Mehdi Rajabnia; AMirhosein Maali; Elaheh Ferdosi-Shahandashti. "Integron and its role in antimicrobial resistance: A literature review on some bacterial pathogens". , 24, 2, 1399, 136-142. doi: 10.22038/ijbms.2020.48905.11208
Sabbagh, Parisa, Rajabnia, Mehdi, Maali, AMirhosein, Ferdosi-Shahandashti, Elaheh. (1399). 'Integron and its role in antimicrobial resistance: A literature review on some bacterial pathogens', , 24(2), pp. 136-142. doi: 10.22038/ijbms.2020.48905.11208
Sabbagh, Parisa, Rajabnia, Mehdi, Maali, AMirhosein, Ferdosi-Shahandashti, Elaheh. Integron and its role in antimicrobial resistance: A literature review on some bacterial pathogens. , 1399; 24(2): 136-142. doi: 10.22038/ijbms.2020.48905.11208

Integron and its role in antimicrobial resistance: A literature review on some bacterial pathogens

Iranian Journal of Basic Medical Sciences
مقاله 2، دوره 24، شماره 2، اردیبهشت 2021، صفحه 136-142    اصل مقاله (647.99 K)
نوع مقاله: Review Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2020.48905.11208
نویسندگان
Parisa Sabbagh1؛ Mehdi Rajabnia1، 2؛ AMirhosein Maali3، 4؛ Elaheh Ferdosi-Shahandashti* 1، 5
1Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
2Department of Microbiology, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran
3Student Research Committee, Pasteur Institute of Iran, Tehran, Iran
4Department of Medical Biotechnology, Faculty of Allied Medicine, Qazvin University of Medical Sciences, Qazvin, Iran
5Department of Medical Biotechnology, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran
چکیده
In recent years, different acquired resistance mechanisms, including transposons, bacteriophages, plasmids, and integrons have been identified as involved in the spread of resistance genes in bacteria. The role of integrons as mobile genetic elements playing a central role in antibiotic resistance has been well studied and documented. Integrons are the ancient structures that mediate the evolution of bacteria by acquiring, storing, disposing, and resorting to the reading frameworks in gene cassettes. The term integron describes a large family of genetic elements, all of which are able to capture gene cassettes. Integrons were classified into three important classes based on integrase intI gene sequence. Integrons can carry and spread the antibiotic resistance genes among bacteria and are among the most significant routes of distribution of resistance genes via horizontal transfer. All integrons have three essential core features. The first feature is intI, the second one is an integron-associated recombination site, attI, and an integron-associated promoter, Pc, is the last feature. Among them, the class 1 integron is a major player in the dissemination of antibiotic resistance genes across pathogens and commensals. Various classes of integrons possessing a wide variety of gene cassettes are distributed in bacteria throughout the world. This review thus focuses on the distribution of integrons among important bacteria.
کلیدواژه‌ها
Antibiotic resistance؛ Gene cassettes؛ Integrases؛ Integrons؛ Mobile elements
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