Akiyama H, Hashimoto H, Kawabe J,
Higashiyama S, Kai T, Kataoka K,
Shimada A, Inoue K, Shiomi S, Kiriike N.
2008. The relationship between depressive
symptoms and prefrontal hypoperfusion
demonstrated by eZIS in patients with
DAT. Neurosci lett, 441: 328-331.
Alqasoumi S. 2012. Anti-secretagogue and
antiulcer effects of Cinnamon
Cinnamomum zeylanicum in rats. J.
Pharmacogn Phytother, 4: 53-61.
Amiri S, Amini-Khoei H, Mohammadi-Asl A,
Alijanpour S, Haj-Mirzaian A, RahimiBalaei M, Razmi A, Olson, CO, Rastegar
M, Mehdizadeh, M, Zarrindast MR. 2016.
Involvement of D1 and D2 dopamine
receptors in the antidepressant-like effects
of selegiline in maternal separation model
of mouse. Physiol Behav, 163: 107-14.
Andrade L, Caraveo-Anduaga JJ, Berglund P,
Bijl RV, De Graaf R, Vollebergh W,
Dragomirecka E, Kohn R, Keller M,
Kessler RC, Kawakami N, Kilic C, Offord
D, Ustun TB, Wittchen HU. 2003. The
epidemiology of major depressive
episodes: results from the International
Consortium of Psychiatric Epidemiology
(ICPE) Surveys. Int J Methods Psychiatr
Res, 12: 3-21.
Ashwani A, Preeti V. 2012. A review of
pathophysiology, classification and long
term course of depression. IRJP, 3: 90-96.
Bamji SX, Majdan M, Pozniak CD, Belliveau
DJ, Aloyz R, Kohn J, Causing CG, Miller
FD. 1998. The p75 neurotrophin receptor
mediates neuronal apoptosis and is
essential for naturally occurring
Cinnamomum zeylanicum and depression
AJP, Vol. 11, No. 3, May-Jun 2021 311
sympathetic neuron death. J Cell Biol, 140:
911-923.
Binder DK, Scharfman HE. 2004. Brainderived neurotrophic factor. Growth
Factors, 22: 123-31.
Carney RM, Freedland KE. 2017. Depression
and coronary heart disease. Nat Rev
Cardiol, 14: 145-155.
George MS, Ketter TA, Post RM. 1994.
Prefrontal cortex dysfunction in clinical
depression. Depression, 2: 59-72.
Ghaderi H, Rafieian M, Nezhad H. 2018. Effect
of hydroalcoholic Cinnamomum
zeylanicum extract on reserpine-induced
depression symptoms in mice.
Pharmacophore, 9: 35-44.
Ghaderkhani S, Moloudi MR, Izadpanah E,
Mohammadi R, Rostami A, Khomand P,
Hassanzadeh K. 2014. Effect of
hydroalcoholic extract of cinnamomum on
strychnine-induced seizure in mice. J
Isfahan Med Sch, 32: 1388-1395.
Govitrapong P, Suttitum T, Kotchabhakdi N,
Uneklabh T. 1998. Alterations of immune
functions in heroin addicts and heroin
withdrawal subjects. J Pharmacol Exp
Ther, 286: 883-889.
Grimm S, Beck J, Schuepbach D, Hell D,
Boesiger P, Bermpohl F, Niehaus L,
Boeker H, Northoff G. 2008. Imbalance
between left and right dorsolateral
prefrontal cortex in major depression is
linked to negative emotional judgment: an
fMRI study in severe major depressive
disorder. Biol Psychiatry, 63: 369-376.
Hackley B. 2010. Antidepressant medication
use in pregnancy. J Midwifery Womens
Health, 55: 90-100.
Haj-Mirzaian A, Amiri S, Kordjazy N, RahimiBalaei M, Haj-Mirzaian, A, Marzban H,
Aminzadeh A, Dehpour AR, Mehr SE.
2015. Blockade of NMDA receptors
reverses the depressant, but not anxiogenic
effect of adolescence social isolation in
mice. Eur J Pharmacol, 750: 160-
166.
Huang X, Mao YS, Li C, Wang H, Ji JL. 2014.
Venlafaxine inhibits apoptosis of
hippocampal neurons by up-regulating
brain-derived neurotrophic factor in a rat
depression model. Int J Clin Exp Pathol, 7:
4577-4586.
Iwamoto K, Nakatani N, Bundo M, Yoshikawa
T, Kato T. 2005. Altered RNA editing of
serotonin 2C receptor in a rat model of
depression. Neurosci Res, 53: 69-76.
Izadpanah E, Nikandam F, Moloudi MR,
Hassanzadeh K. 2016. Evaluation of the
analgesic effect of hydroalcoholic extract
of Cinnamomum in rats. SJKUMS, 21: 41-
48.
Jana A, Modi K, Roy A, Anderso J, van
Breemen R, Pahan K. 2013. Up-Regulation
of Neurotrophic Factors by Cinnamon and
its Metabolite Sodium Benzoate:
Therapeutic Implications for
Neurodegenerative Disorders. JNIP, 8:
739-755.
Jiao Y, Palmgren B, Novozhilova E, Englund
Johansson U, Spieles-Engemann AL, Kale
A, Stupp SI, Olivius P. 2014. BDNF
increases survival and neuronal
differentiation of human neural precursor
cells cotransplanted with a nanofiber gel to
the auditory nerve in a rat model of
neuronal damage. Biomed Res Int, 2014: 1-
11.
Kalayam B, Alexopoulos GS. 1999. Prefrontal
dysfunction and treatment response in
geriatric depression. Arch Gen Psychiatry,
56: 713-18.
Khan A, Safdar M, Ali Khan MM, Khattak KN,
Anderson RA. 2003. Cinnamon improves
glucose and lipids of people with type 2
diabetes. Diabetes Care, 26: 3215-8.
Li YR, Fu CS, Yang WJ, Wang XL, Feng D,
Wang XN, Ren DM, Lou HX, Shen T.
2018. Investigation of constituents from
Cinnamomum camphora (L.) J. Presl and
evaluation of their anti-inflammatory
properties in lipopolysaccharide-stimulated
RAW 264.7 macrophages. J
Ethnopharmacol, 221: 37-47.
Ma M, Ren Q, Yang C, Zhang Jc, Yao W, Dong
C, Ohgi Y, Futamura T, Hashimoto K.
2016. Adjunctive treatment of
brexpiprazole with fluoxetine shows a rapid
antidepressant effect in social defeat stress
model: Role of BDNF-TrkB signaling. Sci
Rep, 6: 39209.
Mancini-Filho J, Van-Koiij A, Mancini D,
Cozzolino F, Torres R. 1998. Antioxidant
activity of cinnamon (Cinnamomum
Zeylanicum, Breyne) extracts. Bollettino
chimico farmaceutico, 137: 443.
Mansson D. 2019. Looking to the future of
depression: instant diagnosis and
medication-free treatment. Future science
OA, 5: FSO415.
Aryanezhad et al.
AJP, Vol. 11, No. 3, May-Jun 2021 312
Masi G, Brovedani P. 2011. The hippocampus,
neurotrophic factors and depression:
possible implications for the
pharmacotherapy of depression. CNS
Drugs, 25: 913-931.
McAllister AK, Katz LC, Lo DC. 1996.
Neurotrophin regulation of cortical
dendritic growth requires activity. Neuron,
17: 1057-1064.
McAllister AK, Katz LC, Lo DC. 1999.
Neurotrophins and synaptic plasticity.
Annu Rev Neurosci, 22: 295-318.
Moinuddin G, Devi K, Khajuria DK. 2012.
Evaluation of the anti–depressant activity
of Myristica fragrans (Nutmeg) in male
rats. Avicenna J. Phytomedicine, 2: 72-78.
Moloudi MR, Moqbel H, Dastan D,
Hasanzadeh K, Noori B, Izadpanah E.
2018. Effect of Hydro-alcoholic extract of
Jasminum sambac on morphine withdrawal
symptoms in rats. SJKUMS, 23: 1-7.
Montazeri A, Mousavi SJ, Omidvari S, Tavousi
M, Hashemi A, Rostami T. 2013.
Depression in Iran: a systematic review of
the literature (2000_2010). Payesh, 12:
567-594.
Murphy FC, Nimmo-Smith I, Lawrence, AD.
2003. Functional neuroanatomy of
emotions: a meta-analysis. Cogn Affect
Behav Neurosci, 3: 207-233.
Nestler E, Barrot M, DiLeone R, Eisch A, Gold
S, Monteggia L. 2002. Neurobiology of
Depression. Neuron, 34: 13-25.
Null G, Pennesi L, Feldman M. 2017. Nutrition
and Lifestyle Intervention on Mood and
Neurological Disorders. Evid Based
Complementary Altern Med, 22: 68-74.
Ouattara B, Simard RE, Holley RA, Piette GJ,
Begin A. 1997. Antibacterial activity of
selected fatty acids and essential oils
against six meat spoilage organisms. Int J
Food Microbiol, 37: 155-162.
Patro G, Bhattamisra SK, Mohanty BK. 2016.
Effects of Mimosa pudica L. leaves extract
on anxiety, depression and memory.
Avicenna J. Phytomedicine, 6: 696-710
Rabadia J, Satish S, Ramanjaneyulu V. 2013.
"An Investigation of Anti-Depressant
Activity of Cinnamomum Camphora Oil in
Experimental Mice ". Asian j biomed
pharm, 3: 44-46.
Rabie MA, Mohsen M, Ibrahim M, El-Sawy
Mahmoud R. 2014. Serum level of brain
derived neurotrophic factor (BDNF) among
patients with bipolar disorder. J Affect
Disord, 162: 67-72.
Ranasinghe P, Pigera S, Premakumara GA,
Galappaththy P, Constantine GR,
Katulanda P. 2013. Medicinal properties of
'true' cinnamon (Cinnamomum
zeylanicum): a systematic review. BMC
Complement Altern Med: 13: 2-10.
Rao PV, Gan SH. 2014. Cinnamon: a
multifaceted medicinal plant. Evid Based
Complement Alternat Med, 2014: 642942.
Saarelainen T, Hendolin P, Lucas G, Koponen
E, Sairanen M, MacDonald E, Agerman K,
Haapasalo A, Nawa H, Aloyz R, Ernfors P,
Castren E. 2003. Activation of the TrkB
neurotrophin receptor is induced by
antidepressant drugs and is required for
antidepressant-induced behavioral effects.
J Neurosci, 23: 349-57.
Shen Y, Fukushima M, Ito Y, Muraki E,
Hosono T, Seki T, Ariga T. 2010.
Verification of the antidiabetic effects of
cinnamon (Cinnamomum zeylanicum)
using insulin-uncontrolled type 1 diabetic
rats and cultured adipocytes. Biosci
Biotechnol Biochem, 74: 2418-2425.
Shirayama Y, Chen AC, Nakagawa S, Russell
DS, Duman RS. 2002. Brain-derived
neurotrophic factor produces
antidepressant effects in behavioral models
of depression. J Neurosci, 22: 3251-3261.
Steptoe A, Tsuda A, Tanaka Y, Wardle J. 2007.
Depressive symptoms, socio-economic
background, sense of control, and cultural
factors in university students from 23
countries. Int J Behav Med, 14: 97-107.
Tepe AS, Ozaslan M. 2020. Anti-alzheimer,
anti-diabetic, skin-whitening, and
antioxidant activities of the essential oil of
Cinnamomum zeylanicum. Ind Crops Prod,
145: 112069.
Thompson Ray M, Weickert CS, Wyatt E,
Webster MJ. 2011. Decreased BDNF, trkBTK+ and GAD67 mRNA expression in the
hippocampus of individuals with
schizophrenia and mood disorders. J
Psychiatry Neurosci, 36: 195-203.
Van Diermen D, Marston A, Bravo J, Reist M,
Carrupt PA, Hostettmann K. 2009.
Monoamine oxidase inhibition by Rhodiola
rosea L. roots. J Ethnopharmacol, 122: 397-
401.
Zhou D, Zhang Z, Liu L, Li C, Li M, Yu H, Cai
X, Sun X, Shen X, Wang J, Geng J, Wang
C, Shi Y. 2017. The antidepressant-like
Cinnamomum zeylanicum and depression
AJP, Vol. 11, No. 3, May-Jun 2021 313
effects of biperiden may involve
BDNF/TrkB signaling-mediated BICC1
expression in the hippocampus and
prefrontal cortex of mice. Pharmacol
Biochem Behav, 157: 47-57.