The effect of royal jelly and silver nanoparticles on liver and kidney inflammation | ||
| Avicenna Journal of Phytomedicine | ||
| مقاله 2، دوره 11، شماره 3، مرداد و شهریور 2021، صفحه 218-223 اصل مقاله (381.91 K) | ||
| نوع مقاله: Short communication | ||
| شناسه دیجیتال (DOI): 10.22038/ajp.2020.17045 | ||
| نویسندگان | ||
| Hossein Pourmobini1؛ Mohammad Kazemi-arababadi2؛ Mohammad Reza Salahshoor3؛ Shiva Roshankhah3؛ Mohammad Mohsen Taghavi4؛ Zahra Taghipour5؛ Ahmad Shabanizadeh* 6 | ||
| 1Immunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences | ||
| 2Department of Immunology, Faculty of Medicine, Immunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran | ||
| 3Department of Anatomical Sciences, Medical School, Kermanshah University of Medical Sciences, Kermanshah, Iran | ||
| 4Department of Anatomy, Faculty of Medicine, Social Determinants of Health Research center Rafsanjan University of Medical Sciences, Rafsanjan, Iran | ||
| 5Department of Anatomy, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran | ||
| 6Department of Anatomy, Faculty of Medicine, Immunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran | ||
| چکیده | ||
| Objective: Royal jelly (RJ) is a honey bee product for which, anti-inflammatory properties were shown in vitro. Nanoparticles, including nano-silver (NS), are plausible inflammation inducers that act by activation of immune cells and consequent production of pro-inflammatory cytokines. This project aimed to explore immunomodulatory effects of royal jelly and nano-silver on the kidney and liver. Materials and Methods: In this project, 40 male rats were grouped as follows: 10 rats as controls, 10 rats treated with RJ; 10 rats treated with both NS and RJ and 10 rats treated with NS. Liver and kidney interleukin (IL)-1β, -2, -6, and -33 levels were determined using commercial ELISA kits. Results: RJ reduced kidney IL-6 levels in comparison to control and NS--RJ groups. RJ and NS reduced kidney and liver IL-1β levels. Kidney IL-33 levels were decreased in the RJ and nano-silver groups in comparison to the NS--RJ group. Conclusion: Based on this study, it may be concluded that RJ together with NS can play anti-inflammatory roles and may affect the function of immune cells. | ||
| کلیدواژهها | ||
| Kidney؛ Liver؛ Nano-silver؛ Royal jelly | ||
| مراجع | ||
|
Ahmed MM, El-Shazly SA, Alkafafy ME, Mohamed AA, Mousa AA. 2018. Protective potential of royal jelly against cadmium-induced infertility in male rats. Andrologia, 50: e12996. Au-Yeung BB, Smith GA, Mueller JL, Heyn CS, Jaszczak RG, Weiss A, Zikherman J. 2017. IL-2 Modulates the TCR Signaling Threshold for CD8 but Not CD4 T Cell Proliferation on a Single-Cell Level. J Immunol, 198: 2445-2456. Borthwick LA. 2016. The IL-1 cytokine family and its role in inflammation and fibrosis in the lung. Semin Immunopathol, 38: 517- 534. Delkhoshe-Kasmaie F, Malekinejad H, Khoramjouy M, Rezaei-Golmisheh A &Janbaze-Acyabar H. 2014. Royal jelly protects from taxol-induced testicular damages via improvement of antioxidant status and up-regulation of E2f1. Syst Biol Reprod Med, 60: 80-88. El-Gayar MH, Aboshanab KM, Aboulwafa M M, Hassouna NA. 2016. Antivirulence and wound healing effects of royal jelly and garlic extract for the control of MRSA skin infections. Wound Med, 13: 18-27. Kamakura M. 2011. Royalactin induces queen differentiation in honeybees. Nature, 473: 478-483. Klingelfus T, Disner G R, Voigt CL, Alle LF, Cestari MM, Leme DM. 2019. Nanomaterials induce DNA-protein crosslink and DNA oxidation: A mechanistic study with RTG-2 fish cell line and Comet assay modifications. Chemosphere, 215: 703-709. Locht LJ, Pedersen MO, Markholt S, Bibby B M, Larsen A, Penkowa M, Stoltenberg M Rungby J. 2011. Metallic silver fragments cause massive tissue loss in the mouse brain. Basic Clin Pharmacol Toxicol, 109: 1-10. Metwally Ibrahim SL, Kosba AA. 2018. Royal jelly supplementation reduces skeletal Nano-silver, royal jelly and cytokines AJP, Vol. 11, No. 3, May-Jun 2021 223 muscle lipotoxicity and insulin resistance in aged obese rats. Pathophysiology, 25: 307- 315. Nakkala JR, Mata R, Raja K, Khub Chandra V, Sadras SR. 2018. Green synthesized silver nanoparticles: Catalytic dye degradation, in vitro anticancer activity and in vivo toxicity in rats. Mater Sci Eng C Mater Biol Appl, 91: 372-381. Nakkala JR, Mata R, Sadras SR. 2017. Green synthesized nano silver: Synthesis, physicochemical profiling, antibacterial, anticancer activities and biological in vivo toxicity. J Colloid Interface Sci, 499: 33-45. Nascimento AP, Moraes L. A, Ferreira NU, Moreno Gde P, Uahib FG, Barizon EA , Berretta AA. 2015. The Lyophilization Process Maintains the Chemical and Biological Characteristics of Royal Jelly. Evid Based Complement Alternat Med, 2015: 825068. Pavel CI, Mărghitaş L A, Bobiş O, Dezmirean DS, Şapcaliu A, Radoi I , Mădaş MN. 2011. Biological activities of royal jelly-review. Sci Papers Anim Sci Biotec, 44: 108-118. Rahmanzadeh-Shahi S, Golshiri-Isfahani A, Fathollahi MS, Rezayati M, Bahramabadi R, Afrooz M, Asadikaram G., Kennedy D, Arababadi MK. 2018. Interleukin-6 and Tumor Growth Factor-beta are Risk Factors for Idiopathic Epistaxis. Lab Med, 49: 329- 341. Ramadan MF , Al-Ghamdi A. 2012. Bioactive compounds and health-promoting properties of royal jelly: A review. J funct Food, 4: 39-52. Sepehri Z, Kiani Z, Afshari M, Kohan F, Dalvand A, Ghavami S. 2017. Inflammasomes and type 2 diabetes: An updated systematic review. Immunol Lett, 192: 97-103. Sharma VK, Yngard RA , Lin Y. 2009. Silver nanoparticles: green synthesis and their antimicrobial activities. Adv coll interface sci, 145: 83-96. Shin SH, Ye MK, Kim HS , Kang HS. 2007. The effects of nano-silver on the proliferation and cytokine expression by peripheral blood mononuclear cells. Int Immunopharmacol, 7: 1813-8. Silici S, Ekmekcioglu O, Eraslan G , Demirtas A. 2009. Antioxidative effect of royal jelly in cisplatin-induced testes damage. Urology, 74: 545-51. Song JY , Kim BS. 2009. Rapid biological synthesis of silver nanoparticles using plant leaf extracts. Bioproces biosystem engineer, 32: 79. Tong X, Barbour M, Hou K, Gao C, Cao S, Zheng J, Zhao Y, Mu R , Jiang HR. 2016. Interleukin-33 predicts poor prognosis and promotes ovarian cancer cell growth and metastasis through regulating ERK and JNK signaling pathways. Mol Oncol, 10: 113-25. Wang JJ. Xue YY, Tang M. 2016. [Antimicrobial applications and toxicity of nano-silver in the medical field]. Zhonghua Shao Shang Za Zhi, 32: 631-634. You MM, Chen YF, Pan Y M, Liu YC, Tu J, Wang K , Hu FL. 2018. Royal Jelly Attenuates LPS-Induced Inflammation in BV-2 Microglial Cells through Modulating NF-kappaB and p38/JNK Signaling Pathways. Mediators Inflamm, 2018: 7834381. | ||
|
آمار تعداد مشاهده مقاله: 9,584 تعداد دریافت فایل اصل مقاله: 1,179 |
||