Possible potential of Astrodaucus genus in development of anticancer drugs | ||
Avicenna Journal of Phytomedicine | ||
مقاله 2، دوره 11، شماره 1، فروردین و اردیبهشت 2021، صفحه 11-21 اصل مقاله (628.63 K) | ||
نوع مقاله: Review Article | ||
شناسه دیجیتال (DOI): 10.22038/ajp.2020.17027 | ||
نویسندگان | ||
Narges Ghorbani Hesari1؛ Zahra Tofighi1؛ Seyedeh Fatemeh Shirmardi1؛ Seyed Mostafa Hashemi1؛ Abbas Hadjiakhoondi2؛ Saied Goodarzi* 3 | ||
1Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran | ||
2Departments of Pharmacognosy and Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran | ||
3Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran | ||
چکیده | ||
Objective: Many pharmaceutical factories have dramatically improved the quality of herbal remedies in cancer treatment. The results of somestudies have shown anticancer effect of Astrodaucus genus. Therefore, the aim of this article was to review the chemical ingredients and biological effects of Astrodaucus genus especially A. persicus from the family Apiaceae (Umbelliferae). Materials and Methods: Online databases ScienceDirect, PubMed, Scopus, and Google Scholar were searched using the keywords Astrodaucus, Apiaceae, Biologic, Phytochemistry, and Benzodioxole to retrieve studies published between 1970 and 2020. Results: The Astrodaucus genus has two species, Astrodaucus persicus (Boiss.) Drude and Astrodaucus orientalis (L.) Drude. In this genus, 5 new biologically active phytochemicals with benzodioxole structure were introduced and their biological effects were assessed. Conclusion: Since many of the most commonly used anticancer drugs such as etoposide, teniposide, podophyllotoxin and sanguinarine have benzodioxole structureand according to the results of biological tests, it seems that more researchwith these perspectives should be done on this genus. | ||
کلیدواژهها | ||
Astrodaucus؛ Apiaceae؛ Biologic؛ Phytochemistry؛ Benzodioxole | ||
مراجع | ||
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