Figueiredo, Célia Cristina Malaguti, Gomes, Amanda, Granero, Filipe, Bronzel Junior, João Luiz, Silva, Luciana, Ruiz, Ana Lúcia Tasca Gois, Silva, Regildo Márcio Gonçalves da. (1400). Antiglycation and antitumoral activity of Tribulus terrestris dry extract. , 11(3), 224-237. doi: 10.22038/ajp.2020.16957
Célia Cristina Malaguti Malaguti Figueiredo; Amanda Costa Gomes; Filipe Oliveira Granero; João Luiz Bronzel Junior; Luciana Pereira Silva; Ana Lúcia Tasca Gois Ruiz; Regildo Márcio Gonçalves da Silva. "Antiglycation and antitumoral activity of Tribulus terrestris dry extract". , 11, 3, 1400, 224-237. doi: 10.22038/ajp.2020.16957
Figueiredo, Célia Cristina Malaguti, Gomes, Amanda, Granero, Filipe, Bronzel Junior, João Luiz, Silva, Luciana, Ruiz, Ana Lúcia Tasca Gois, Silva, Regildo Márcio Gonçalves da. (1400). 'Antiglycation and antitumoral activity of Tribulus terrestris dry extract', , 11(3), pp. 224-237. doi: 10.22038/ajp.2020.16957
Figueiredo, Célia Cristina Malaguti, Gomes, Amanda, Granero, Filipe, Bronzel Junior, João Luiz, Silva, Luciana, Ruiz, Ana Lúcia Tasca Gois, Silva, Regildo Márcio Gonçalves da. Antiglycation and antitumoral activity of Tribulus terrestris dry extract. , 1400; 11(3): 224-237. doi: 10.22038/ajp.2020.16957

Antiglycation and antitumoral activity of Tribulus terrestris dry extract

Avicenna Journal of Phytomedicine
مقاله 3، دوره 11، شماره 3، مرداد و شهریور 2021، صفحه 224-237    اصل مقاله (664.95 K)
نوع مقاله: Original Research Article
شناسه دیجیتال (DOI): 10.22038/ajp.2020.16957
نویسندگان
Célia Cristina Malaguti Malaguti Figueiredo1؛ Amanda Costa Gomes1؛ Filipe Oliveira Granero1؛ João Luiz Bronzel Junior1؛ Luciana Pereira Silva2؛ Ana Lúcia Tasca Gois Ruiz3؛ Regildo Márcio Gonçalves da Silva* 4
1São Paulo State University (UNESP), Institute of Chemistry, Araraquara, São Paulo, Brazil
2Fundação Educacional do Município de Assis (FEMA), Assis, São Paulo, Brazil
3University of Campinas (UNICAMP), Faculty of Pharmaceutical Sciences, Campinas, São Paulo, Brazil
4São Paulo State University (UNESP), School of Sciences, Humanities and Languages, Department of Biotechnology, Laboratory of Herbal Medicine and Natural Products, Assis, São Paulo, Brazil
چکیده
Objective: Investigation of the antiglycation and antitumoral potential of standardized and saponins-enriched extracts of Tribulus terrestris herbal medicine.
Materials and Methods: The procedures for the evaluation of the antiglycation activity of the standardized (TtSE) and saponins-enriched (TtEE) extracts of T. terrestris were: determination of relative mobility in electrophoresis (RME), free amino groups using OPA method and advanced glycation end-products (AGEs) fluorescence. Antioxidant activity was determined by DPPH radical scavenging test. In vitro antitumor activity of TtSE and TtEE was evaluated in human tumor cell lines.
Results: The results were obtained by antiglycation tests (RME, OPA method and AGEs fluorescence determination), using BSA as protein and ribose as glycation agent, and antioxidant assay (DPPH test); it was verified that both extracts of T. terrestris have antiglycation and antioxidant activity. In addition, the extracts were able to induce death of more than 50% of human tumor cell lines.
Conclusion: The present study showed that standardized and saponins-enriched extracts of T. terrestris herbal medicine present antiglycation and antioxidant and antiproliferative action in human tumor cells lines. The saponins-enriched extract proved a greater antiglycation and antioxidant activity in comparison to the standardized type.
کلیدواژه‌ها
Tribulus terrestris؛ Antiproliferative؛ Protein glycation؛ Steroidal saponins
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